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Lmbr1tm1Kng
Targeted Allele Detail
Summary
Symbol: Lmbr1tm1Kng
Name: limb region 1; targeted mutation 1, David M Kingsley
MGI ID: MGI:3579991
Synonyms: Lmbr1ATG
Gene: Lmbr1  Location: Chr5:29434800-29583414 bp, - strand  Genetic Position: Chr5, Syntenic
Alliance: Lmbr1tm1Kng page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:72166
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A 1.1 kb sequence containing 365 bp upstream of the predicted translational start site of exon 1 and 696 bp downstream of the exon 1 splice donor site was replaced with a PGKneo selection cassette. The deleted sequence was common to both known transcripts. Northern blot of mutant brains suggested that the allele may not have been a null as overexposure to probes demonstrated transcripts at ~7% of wild-type levels. (J:72166)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lmbr1 Mutation:  33 strains or lines available
References
Original:  J:72166 Clark RM, et al., Reciprocal mouse and human limb phenotypes caused by gain- and loss-of-function mutations affecting lmbr1. Genetics. 2001 Oct;159(2):715-26
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory