Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Perspectives on the Mechanism and Function of Cell Death in Health and Disease
Discussion Leader: Ana Garcia-Saez (University of Cologne, Germany)
7:40 pm - 8:25 pm
Manolis Pasparakis (University of Cologne, Germany)
"Regulation of Necroptosis and Its Role in Inflammation"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:20 pm
Francis Chan (Liangzhu Laboratory, Zhejiang University, China)
"Transcending Death: Necroptosis-Independent Functions of RIP Kinases"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Fundamental Mechanisms of Cell Death
Discussion Leaders: Lynn Wong (University of Zurich, Switzerland) and Douglas Green (St. Jude Children's Research Hospital, United States)
9:00 am - 9:15 am
Andrew Oberst (University of Washington, United States)
"Cell Death-Independent Roles of the Necroptotic Pathway"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Kim Newton (Genentech, United States)
"The Good and The Bad of Caspase Inhibition"
9:35 am - 9:40 am
Discussion
9:40 am - 10:00 am
Mathieu Bertrand (Ghent University, Belgium)
"Repression of TNF Cytotoxicity by Unconventional Autophagy"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Tiffany Reese (University of Texas Southwestern Medical Center, United States)
"Viral Mimicry of a Cell Death Protein to Induce Viral Egress"
11:00 am - 11:15 am
Discussion
11:15 am - 11:30 am
Sandra Zinkel (Vanderbilt University School of Medicine, United States)
"RIPK1-Mediated Inflammation Impairs Hematopoiesis in the Setting of TET2 Loss"
11:30 am - 11:35 am
Discussion
11:35 am - 11:50 am
Melanie Fritsch (University Hospital Cologne, Germany)
"RIPK1 Kinase Activity Promotes Inflammatory Disease in Mice when Apoptosis and Necroptosis are Blocked"
11:50 am - 11:55 am
Discussion
11:55 am - 12:15 pm
John Silke (Walter and Eliza Hall Institute of Medical Research, Australia)
"Zounds, Wounds, Cell Death and Healing"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Lynn Wong (University of Zurich, Switzerland) and Monica Yabal (Technical University of Munich, Germany)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Innate Immune Sensing and Cell Death
Discussion Leaders: Katia Cosentino (University of Osnabrück, Germany) and Andrew Oberst (University of Washington, United States)
7:30 pm - 7:50 pm
Kate Schroder (The University of Queensland, Australia)
"Die Hard: Cell Explosion by Pyroptosis Escalates Immune Responses"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Theresa Pizarro (Case Western Reserve University School of Medicine, United States)
"Live or Let Die: Translational Insights and Clinical Perspectives of Gasdermin B"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Yi-Nan Gong (University of Pittsburgh, Hillman Cancer Center, UPMC, United States)
"Cathepsin S is the Protease for Intestinal Gasdermin C Amplifying Type 2 Immunity"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Jiyi Pang (Walter and Eliza Hall Institute, Australia)
"Cytokine Combinations to Drive iNOS Production and Cell Death in Inflammatory Bowel Disease: Insights from the Study of Human Intestinal Organoids"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Kate Fitzgerald (Umass Chan Medical School, United States)
"Regulation of Inflammasome Driven Responses"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Regulation of Lytic Forms of Cell Death
Discussion Leader: Kate Schroder (The University of Queensland, Australia)
9:00 am - 9:20 am
James Murphy (Walter and Eliza Hall Institute of Medical Research, Australia)
"Every Dead Thing - the Necroptotic Dead Enzyme, MLKL, in Health and Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Katia Cosentino (University of Osnabrück, Germany)
"Decoding Gasdermin Pore Formation at The Single-Molecule Level"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Domagoj Vucic (Genentech, United States)
"Harnessing Cell Death Pathways for Therapeutic Intervention in Inflammatory Diseases"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Monica Yabal (Technical University of Munich, Germany)
"Microbial Regulation of Cell-Death in The Intestinal Tract"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Hirotsugu Oda (University of Cologne, Germany)
"Human SHARPIN Deficiency Induces Autoinflammation and Immunodeficiency"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Hongyan Guo (LSUHSC Shreveport, United States)
"Species of RIPK3 Dictates a Requirement for RIPK1 in ZBP1-Dependent Necroptosis"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Feng Shao (National Institute of Biological Sciences, Beijing, China)
"Gasdermin-Mediated Pyroptosis: Mechanisms & Therapeutics Potentials"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Inflammation and Cell Death
Discussion Leaders: John Silke (Walter and Eliza Hall Institute of Medical Research, Australia) and Stephen Tait (Cancer Research UK Scotland Institute, United Kingdom)
7:30 pm - 7:50 pm
Kevin Ryan (Cancer Research UK Scotland Institute, United Kingdom)
"Connecting Autophagy and Inflammation to Regulate Programmed Cell Death"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Deepa Sathyaseelan (University of Oklahoma Health Sciences Center, United States)
"The Role of Hepatocyte MLKL in Liver-Brain Crosstalk"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Mari Dezawa (Tohoku University Graduate School of Medicine, Japan)
"Cell Replacement Therapy Harnessing the Phagocytic Activity of Endogenous Reparative Macrophage-Like Pluripotent Muse Cells"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Lynn Wong (University of Zurich, Switzerland)
"XIAP: Driving Inflammation or Cell Death?"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Kodi Ravichandran (Washington University School of Medicine, United States)
"Death in the Neighbourhood and Tissue Responses"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell Death Signalling Platforms
Discussion Leaders: Kevin Ryan (Cancer Research UK Scotland Institute, United Kingdom) and Kim Newton (Genentech, United States)
9:00 am - 9:10 am
Clare Bryant (University of Cambridge, United Kingdom)
"TLR4 Activation of the Triffosome: Common Mechanisms by Which Toll-like Receptors Form Adaptor Protein Signaling Platforms"
9:10 am - 9:15 am
Discussion
9:15 am - 9:35 am
Marion MacFarlane (MRC Toxicology Unit, University of Cambridge, United Kingdom)
"Molecular Architecture of Caspase-8 Signalling Complexes - From Assembly to Co-Ordinated Control of Life/Death Decisions"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
Andreas Villunger (Medical University of Innsbruck, Austria)
"The PIDDosome: A Versatile Signaling Platform Controlling Cell Death and Survival"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Group Photo / Coffee Break
10:45 am - 10:55 am
Mohanish Deshmukh (University of North Carolina, United States)
"Apoptosis in Neurons: Transient and Reversable"
10:55 am - 11:00 am
Discussion
11:00 am - 11:20 am
Heidi McBride (McGill University, Canada)
"A Mitochondria to Lysosome Axis of Pyroptotic Cell Death"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Loren Walensky (Dana-Farber Cancer Institute, United States)
"Inhibition of Oligomeric BAX by an Anti-Apoptotic Dimer"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
DAVID ANDREWS (University of Toronto, Canada)
"The C-Terminal Sequences of Bcl-2 Family Proteins Mediate Direct Binding Interactions that Regulate Cell Death"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Kristopher Sarosiek (Harvard School of Public Health, United States)
"Safely Targeting Endogenous and Therapy-Enhanced BCL-XL Dependence in Ovarian Cancer Using the PROTAC DT2216"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Joseph Opferman (St. Jude Children's Research Hospital, United States)
"MCL-1 and ACSL Family Crosstalk Bridges Apoptosis and Fatty Acid Oxidation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Non-Canonical Forms of Cell Death
Discussion Leader: Mathieu Bertrand (Ghent University, Belgium)
7:30 pm - 7:50 pm
Anthony Letai (Dana-Farber Cancer Institute, United States)
"BCL-2 Family Regulation of Cell Fate in Cancer"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Olaf Groß (University Medical Center Freiburg, Germany)
"Acute Suppression of Mitochondrial ATP Production Prevents Apoptosis and Provides an Essential Signal for NLRP3 Inflammasome Activation"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Lisa-Janina Hohorst (CECAD, University of Cologne, Germany)
"A Story of Dying Cells: Mitochondria Inner Membrane Permeabilization"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Eric Baehrecke (University of Massachusetts Chan Medical School, United States)
"Microglia are Key Executioners of Neuronal Inflammatory Cell Death in a Mouse Model of Vps13D Disease"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Marcus Conrad (Helmholtz Zentrum Munich, Germany)
"Ferroptosis as The Root Cause of Neurodegenerative Disease?"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Cancer and the Immune System
Discussion Leaders: Heidi McBride (McGill University, Canada) and Andreas Villunger (Medical University of Innsbruck, Austria)
9:00 am - 9:20 am
Andreas Strasser (Walter and Eliza Hall Institute of Medical Research, Australia)
"How Does p53 Instruct Cell Fate – Cell Death or Cell Survival and Cell Cycle Arrest?"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Gemma Kelly (Walter and Eliza Hall Institute of Medical Research, Australia)
"Informing Therapeutic Strategies for p53 Defective Cancers"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Stephen Tait (Cancer Research UK Scotland Institute, United Kingdom)
"Mitochondrial and Anti-Tumour Immunity – A Case of Bacterial Mimicry?"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Judy Lieberman (Boston Children's Hospital, Harvard Medical School, United States)
"Blown Apart: Mitochondrial Damage in Pyroptosis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Jason Huska (AbbVie, United States)
"Targeting Tumor Intrinsic TAK1 Engages TNFa-Driven Cell Death Through Distinct Mechanisms and Enhances Cancer Immunotherapy"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Kerstin Brinkmann (Walter and Eliza Hall Institue, Australia)
"What is the Relative Importance of MCL-1’s Anti-Apoptotic vs. Non-Apoptotic Functions in vivo ?"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Jannie Borst (Leiden University Medical Center, The Netherlands)
"Key Elements in The T Cell Response to Cancer"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Inflammation and Tissue Homeostasis
Discussion Leaders: James Murphy (Walter and Eliza Hall Institute of Medical Research, Australia) and Marion MacFarlane (MRC Toxicology Unit, University of Cambridge, United Kingdom)
7:30 pm - 7:50 pm
Andrew Oberst (University of Washington, United States)
"Cell Death-Independent Roles of the "Necroptotic" Pathway"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Katarzyna Groborz (Sanford Burnham Prebys Medical Discovery Institute, United States)
"Deciphering and Visualizing Caspases by Generating Selective Reagents"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Dimitry Ofengeim (Sanofi, United States)
"Glial State Changes and Neuroinflammatory RIPK1 Signaling are a Key Feature of ALS Pathogenesis"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Lorenzo Galluzzi (Weill Cornell Medicine, United States)
"Mitochondria at The Hub of Cell Death and Immunity in Irradiated Cancer Cells"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Douglas Green (St. Jude Children's Research Hospital, United States)
"Flatliners: Near (Cell) Death Experiences"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure