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The A6 is Britain's fourth longest road and one of the main historic north-south roads in England. It currently runs for 299 miles from Luton in Bedfordshire to Carlisle in Cumbria, although it formerly started at a junction with the A1 at Barnet.

Running north west from Luton, the road travels through Bedford, bypasses Rushden, Kettering and Market Harborough, continues through Leicester, Loughborough, Derby and Matlock before going through the Peak District to Bakewell, Buxton, Stockport, Manchester, Salford, Pendleton, Irlams o' th' Height, Pendlebury, Swinton, Walkden, Little Hulton, Bolton, Chorley, Preston, Lancaster, Kendal and Penrith before reaching Carlisle.

See Link (Wikipedia) and Link (SABRE) for more information.

The A6 is one of the main historic north south roads in England. At 299 miles long it is the fourth longest road in the country. It currently runs from Luton in Bedfordshire to Carlisle in Cumbria, although it formerly started at a junction with the A1 at Barnet.
Wikipedia: Link
See also Link for more route detail.