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KEGG   Phascolarctos cinereus (koala): 110201017
Entry
110201017         CDS       T05867                                 
Symbol
ARAF
Name
(RefSeq) LOW QUALITY PROTEIN: serine/threonine-protein kinase A-Raf
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
pcw  Phascolarctos cinereus (koala)
Pathway
pcw01521  EGFR tyrosine kinase inhibitor resistance
pcw01522  Endocrine resistance
pcw04010  MAPK signaling pathway
pcw04012  ErbB signaling pathway
pcw04068  FoxO signaling pathway
pcw04270  Vascular smooth muscle contraction
pcw04650  Natural killer cell mediated cytotoxicity
pcw04720  Long-term potentiation
pcw04726  Serotonergic synapse
pcw04730  Long-term depression
pcw04810  Regulation of actin cytoskeleton
pcw04910  Insulin signaling pathway
pcw04914  Progesterone-mediated oocyte maturation
pcw04928  Parathyroid hormone synthesis, secretion and action
pcw05010  Alzheimer disease
pcw05022  Pathways of neurodegeneration - multiple diseases
pcw05034  Alcoholism
pcw05160  Hepatitis C
pcw05161  Hepatitis B
pcw05200  Pathways in cancer
pcw05205  Proteoglycans in cancer
pcw05208  Chemical carcinogenesis - reactive oxygen species
pcw05210  Colorectal cancer
pcw05211  Renal cell carcinoma
pcw05212  Pancreatic cancer
pcw05213  Endometrial cancer
pcw05214  Glioma
pcw05215  Prostate cancer
pcw05218  Melanoma
pcw05219  Bladder cancer
pcw05220  Chronic myeloid leukemia
pcw05221  Acute myeloid leukemia
pcw05223  Non-small cell lung cancer
pcw05224  Breast cancer
pcw05225  Hepatocellular carcinoma
pcw05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:pcw00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    110201017 (ARAF)
   04012 ErbB signaling pathway
    110201017 (ARAF)
   04068 FoxO signaling pathway
    110201017 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    110201017 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    110201017 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    110201017 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    110201017 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    110201017 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    110201017 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    110201017 (ARAF)
   04720 Long-term potentiation
    110201017 (ARAF)
   04730 Long-term depression
    110201017 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    110201017 (ARAF)
   05205 Proteoglycans in cancer
    110201017 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    110201017 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    110201017 (ARAF)
   05212 Pancreatic cancer
    110201017 (ARAF)
   05225 Hepatocellular carcinoma
    110201017 (ARAF)
   05226 Gastric cancer
    110201017 (ARAF)
   05214 Glioma
    110201017 (ARAF)
   05221 Acute myeloid leukemia
    110201017 (ARAF)
   05220 Chronic myeloid leukemia
    110201017 (ARAF)
   05218 Melanoma
    110201017 (ARAF)
   05211 Renal cell carcinoma
    110201017 (ARAF)
   05219 Bladder cancer
    110201017 (ARAF)
   05215 Prostate cancer
    110201017 (ARAF)
   05213 Endometrial cancer
    110201017 (ARAF)
   05224 Breast cancer
    110201017 (ARAF)
   05223 Non-small cell lung cancer
    110201017 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    110201017 (ARAF)
   05160 Hepatitis C
    110201017 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    110201017 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    110201017 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    110201017 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    110201017 (ARAF)
   01522 Endocrine resistance
    110201017 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pcw01001]
    110201017 (ARAF)
Enzymes [BR:pcw01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     110201017 (ARAF)
Protein kinases [BR:pcw01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   110201017 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like Pkinase_fungal ABC1 Kdo TUG-UBL1 C1_2
Other DBs
NCBI-GeneID: 110201017
NCBI-ProteinID: XP_020832123
UniProt: A0A6P5JFE7
Position
Unknown
AA seq 623 aa
MRRGPTATPVEPSRGLTPPEDSDAIPPTSSRVGGTVKVYLPNQQRTVVTARDGMTVSDSL
DKALKVRGLNQDCCAVYRLVQGRKTATAWDAAIAPLHGEELTVEVRADVPLAAAHNFARK
TFLALTFCDFCRRFLFHGFRCQTCGYKFHQHCSARVPTVCVDMATARQPFYRSVQDLTGG
PGAHEPQPGRQTLCEPLAPKSPRTQTQASHGETFAFPGPGGPPLQRIRSTSTPNVHMIST
TLPVDSRLIQQAAQAVAAEGTVGEKTPQGSPGPSLVSSPGRKSPHPKFSSEPPERKPLSF
ADDKKKVKSLGYRDSGYYWEVAPGEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPT
AEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPAFAIITQWCEGSSLYHHLHVAETHFDMV
QLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQQVE
QPTGSVLWMASEVIRMQDKNPYSFQSDVYAYGVVLYELMSGSLPYSHINNRDQIIFMVGR
GYLSPDLTKVSNNCPKAMKRLLADCLRFQREERPLFPEILVTIELLQRVLPKIERSASEP
SLHRAQTEELPSSLLGALRLFGP
NT seq 1872 nt   +upstreamnt  +downstreamnt
atgagacgaggcccgactgccaccccagtggaaccctccaggggcctaaccccgcctgag
gattctgatgccatccctcccaccagcagtcgggttgggggcactgtgaaggtctatctg
cccaaccagcagcgcacagtggtaactgcgcgggatggcatgaccgtctccgactcgttg
gacaaggcactgaaggtgcggggactgaaccaagactgctgcgctgtctaccgcctcgtg
cagggacggaagaccgcaacagcctgggacgcagccattgctcccttgcacggggaagaa
ctgacggtcgaggtccgggctgatgttccgctcgcggctgcccataactttgcccggaag
acattcctggctctcaccttctgtgacttctgccgccgcttcctcttccatggtttccgt
tgccagacatgtggttacaagttccaccaacactgcagtgcccgcgtccccactgtctgc
gttgacatggccaccgcccgccaacctttctaccgcagtgtccaggacttgactggaggc
cctggtgctcatgagccccagcctggcaggcagaccctatgtgagcccctcgccccaaag
agccccaggacacaaacacaggcctcccatggggagacttttgctttccctgggcctgga
ggcccaccccttcagaggatccgctctacatccacacccaatgtgcacatgatcagcacg
acattgcctgtggacagcaggctcatacagcaggcagcccaggccgttgctgctgaagga
acagtgggggagaagaccccccaaggcagtcctggccccagcctcgtgtcctcccctgga
aggaaatccccacaccccaagttctcatcagagccccctgagcgcaagccccttagcttc
gctgatgataagaagaaagtgaagtctctgggctaccgagactcaggctactattgggag
gtagccccaggggaggtgcaactgctgaagaggatcgggacaggctcatttgggactgtg
ttccgtgggcgatggcatggggatgtggctgtgaaggtgttaaaggtggcgcagcccaca
gctgagcaggcccaggccttcaagaatgagatgcaggtcctcaggaagactcgccatgtg
aatatcctcttgttcatgggattcatgacaaggcccgcctttgccatcatcacccagtgg
tgtgagggttccagcctctaccaccacttgcacgtggctgagactcactttgatatggta
caactcatcgatgtggcccggcagacagctcagggcatggattatctccatgccaagaac
atcattcaccgagatctcaaatccaacaatatctttctgcacgaggggctgacagtgaag
attggagactttgggctggccacagtgaagacccgatggagcggtgcccagcaagtagag
cagcccactggctctgtgctctggatggcctcagaggtgatccgaatgcaggacaagaat
ccctacagcttccagtcggatgtctatgcctacggggtggtcttgtatgagctcatgagt
ggcagtcttccctatagccacatcaacaacagagatcagatcatcttcatggtaggacga
ggttatctgtcgccagacctcaccaaggtctccaacaactgtcctaaagccatgaagaga
ctgctggcagactgtctccgtttccagcgggaggaacggcccttgttccccgagatcctg
gtcaccattgagctgctgcagcgagtgctgcctaagattgagcgcagcgcgtcagagccc
tcgctgcaccgggcccagaccgaggaactgccttcctccttgctgggagccctgcgcctc
ttcgggccctag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (36)   
   KEGG PATHWAY (36)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (11)   
   Pfam (11)   
All databases (58)   

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