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KEGG   Orcinus orca (killer whale): 101289838
Entry
101289838         CDS       T05247                                 
Symbol
PTEN
Name
(RefSeq) phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  KO
K01110  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
Organism
oor  Orcinus orca (killer whale)
Pathway
oor00562  Inositol phosphate metabolism
oor01100  Metabolic pathways
oor01521  EGFR tyrosine kinase inhibitor resistance
oor04068  FoxO signaling pathway
oor04070  Phosphatidylinositol signaling system
oor04071  Sphingolipid signaling pathway
oor04115  p53 signaling pathway
oor04140  Autophagy - animal
oor04150  mTOR signaling pathway
oor04151  PI3K-Akt signaling pathway
oor04218  Cellular senescence
oor04510  Focal adhesion
oor04931  Insulin resistance
oor05165  Human papillomavirus infection
oor05166  Human T-cell leukemia virus 1 infection
oor05200  Pathways in cancer
oor05206  MicroRNAs in cancer
oor05208  Chemical carcinogenesis - reactive oxygen species
oor05213  Endometrial cancer
oor05214  Glioma
oor05215  Prostate cancer
oor05218  Melanoma
oor05222  Small cell lung cancer
oor05224  Breast cancer
oor05225  Hepatocellular carcinoma
oor05230  Central carbon metabolism in cancer
oor05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
oor05415  Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:oor00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101289838 (PTEN)
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    101289838 (PTEN)
   04070 Phosphatidylinositol signaling system
    101289838 (PTEN)
   04071 Sphingolipid signaling pathway
    101289838 (PTEN)
   04151 PI3K-Akt signaling pathway
    101289838 (PTEN)
   04150 mTOR signaling pathway
    101289838 (PTEN)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    101289838 (PTEN)
  09143 Cell growth and death
   04115 p53 signaling pathway
    101289838 (PTEN)
   04218 Cellular senescence
    101289838 (PTEN)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101289838 (PTEN)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101289838 (PTEN)
   05206 MicroRNAs in cancer
    101289838 (PTEN)
   05208 Chemical carcinogenesis - reactive oxygen species
    101289838 (PTEN)
   05230 Central carbon metabolism in cancer
    101289838 (PTEN)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101289838 (PTEN)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    101289838 (PTEN)
   05214 Glioma
    101289838 (PTEN)
   05218 Melanoma
    101289838 (PTEN)
   05215 Prostate cancer
    101289838 (PTEN)
   05213 Endometrial cancer
    101289838 (PTEN)
   05224 Breast cancer
    101289838 (PTEN)
   05222 Small cell lung cancer
    101289838 (PTEN)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101289838 (PTEN)
   05165 Human papillomavirus infection
    101289838 (PTEN)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    101289838 (PTEN)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    101289838 (PTEN)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101289838 (PTEN)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:oor01009]
    101289838 (PTEN)
Enzymes [BR:oor01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     101289838 (PTEN)
    3.1.3.48  protein-tyrosine-phosphatase
     101289838 (PTEN)
    3.1.3.67  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
     101289838 (PTEN)
Protein phosphatases and associated proteins [BR:oor01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Dual specificity phosphatases)
   Phosphatase and Tensin homologs (PTEN)
    101289838 (PTEN)
SSDB
Motif
Pfam: PTEN_C2 Tc-R-P PTP-SAK DSPc PTP-NADK Y_phosphatase PTPlike_phytase Y_phosphatase3 DUF3256
Other DBs
NCBI-GeneID: 101289838
NCBI-ProteinID: NP_001296406
UniProt: A0A024QYS4
Position
14:52794773..52881058
AA seq 573 aa
MERGGEAAAAAAAAAPGRVSESPVTISRAGNAGELVSPLLLPPTRRRRRRHIQGPGPVLN
LPSAAAAPLLARAPEAAGGGSRSEDYSSPHSAAAAARPLAAEEKQAQSLQPSSSRRSSHY
PAAVQNQAAAERGASATAKSRAISILQKKPRHQQLLPSLSSFFFSHRLPDMTAIIKEIVS
RNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNL
CAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGR
TGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRP
VALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMYFEFPQPLPVC
GDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIERAD
NDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVS
DNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV
NT seq 1722 nt   +upstreamnt  +downstreamnt
ctggagcgggggggagaagcggcggcggcggcggcggctgcagctccggggagggtgtcg
gagtcgcctgtcaccatttccagggctgggaacgccggagagttggtctctccccttcta
ctgcctccaacacggcggcggcggcggcggcacatccagggacccgggccggttttaaac
ctcccctccgccgccgccgcacccctcctggcccgggctccggaggccgccggaggaggc
agccgttccgaggattattcttctccccattccgctgccgccgctgccagacctctggct
gctgaggagaagcaggcccagtcgctgcaaccatccagcagccgccgcagcagccattac
ccggctgctgtccagaaccaagcggcagcagagcgaggggcatcagccaccgccaagtcc
agagccatttccatcctgcagaagaagccccgccaccagcagcttctgccatctctctcc
tcctttttcttcagccacaggctcccagacatgacagccatcatcaaagagatcgttagc
agaaacaaaaggagatatcaagaggatggattcgacttagacttgacctatatttatcca
aacattattgccatggggtttcctgcagaaagacttgaaggcgtatacaggaacaatatt
gatgatgtagtaaggtttttggattcaaagcataaaaaccattacaagatatacaatcta
tgtgctgaaagacattatgataccgccaaatttaactgcagagttgcacagtatcctttc
gaagaccataatccaccacagctagaacttatcaaacccttttgtgaagatcttgaccaa
tggctaagtgaagatgacaatcatgtagcagcaattcactgtaaagctggaaagggacga
actggtgtaatgatttgcgcatatttgttacatcggggcaaatttttaaaggcacaagag
gccctagatttctatggggaagtaaggaccagagacaaaaagggagtaactattcccagt
cagaggcgctatgtatattattatagctacctgttaaagaatcatctggattatagacca
gtggcattgttgtttcacaagatgatgtttgaaactattccaatgttcagtggcggaact
tgcaatcctcagtttgtggtctgccagctaaaggtgaagatatattcctccaattcagga
cccacacgacgggaagacaagttcatgtactttgagttccctcagccgttgcctgtgtgt
ggtgacatcaaagtagagttcttccacaaacagaacaagatgctaaaaaaggacaaaatg
tttcacttttgggtaaatacattcttcataccaggaccagaggaaacctcagaaaaagta
gaaaatggaagtctatgtgatcaagaaattgatagtatttgcagtatagagcgtgcagat
aatgacaaggaatatctagtactcactttaacaaaaaatgatctcgacaaagcaaataaa
gacaaggccaaccgatacttttctccaaattttaaggtgaagctgtacttcacaaaaaca
gtagaggagccatcaaatccagaggctagcagttcaacttctgtaacaccagatgttagt
gacaatgaacctgatcattatagatattctgacaccactgactctgatccagagaatgaa
ccttttgatgaagatcagcatacacaaattacaaaagtctga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (28)   
   KEGG PATHWAY (28)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (5)   
   KEGG ENZYME (3)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (3)   
   RefSeq(nuc) (1)   
   GenBank (1)   
   EMBL (1)   
Protein domain (9)   
   Pfam (9)   
All databases (67)   

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