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KEGG   NETWORK: N01425
Entry
N01425                      Network                                
Name
Global genome NER
Definition
(CRL4+DDB2) == (XPC+RAD23A,RAD23B+CETN2) -> (XPC+CETN2) == (ERCC3+ERCC2) == (GTF2H) == (CAK)
  Expanded
(9978+8451+1642+1643) == (7508+5886,5887+1069) -> (7508+1069) == (2071+2068) == (2965+2966+2967+2968+404672) == (1022+902+4331)
Class
nt06502 Nucleotide excision repair
Type
Reference
Pathway
hsa03420  Nucleotide excision repair
Gene
9978  RBX1; ring-box 1
8451  CUL4A; cullin 4A
1642  DDB1; damage specific DNA binding protein 1
1643  DDB2; damage specific DNA binding protein 2
7508  XPC; XPC complex subunit, DNA damage recognition and repair factor
5886  RAD23A; RAD23 homolog A, nucleotide excision repair protein
5887  RAD23B; RAD23 homolog B, nucleotide excision repair protein
1069  CETN2; centrin 2
2071  ERCC3; ERCC excision repair 3, TFIIH core complex helicase subunit
2068  ERCC2; ERCC excision repair 2, TFIIH core complex helicase subunit
2965  GTF2H1; general transcription factor IIH subunit 1
2966  GTF2H2; general transcription factor IIH subunit 2
2967  GTF2H3; general transcription factor IIH subunit 3
2968  GTF2H4; general transcription factor IIH subunit 4
404672  GTF2H5; general transcription factor IIH subunit 5
1022  CDK7; cyclin dependent kinase 7
902  CCNH; cyclin H
4331  MNAT1; MNAT1 component of CDK activating kinase
Reference
PMID:22466610
  Authors
Nakazawa Y, Sasaki K, Mitsutake N, Matsuse M, Shimada M, Nardo T, Takahashi Y, Ohyama K, Ito K, Mishima H, Nomura M, Kinoshita A, Ono S, Takenaka K, Masuyama R, Kudo T, Slor H, Utani A, Tateishi S, Yamashita S, Stefanini M, Lehmann AR, Yoshiura K, Ogi T
  Title
Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair.
  Journal
Nat Genet 44:586-92 (2012)
DOI:10.1038/ng.2229
Reference
PMID:34207557
  Authors
Krasikova Y, Rechkunova N, Lavrik O
  Title
Nucleotide Excision Repair: From Molecular Defects to Neurological Abnormalities.
  Journal
Int J Mol Sci 22:6220 (2021)
DOI:10.3390/ijms22126220

  All links  
Pathway (1)   
   KEGG PATHWAY (1)   
Gene (18)   
   KEGG GENES (18)   
Literature (2)   
   PubMed (2)   
All databases (21)   

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