Entry |
|
Name |
|
Definition |
AFB1 -- (CYP3A4,CYP1A2) -> AFB1-exo-8,9-epoxide == DNA |
Expanded |
C06800 -- (1576,1544) -> C19586 == C00039 |
Class |
nt06250 DNA adduct formation (cancer)
|
Type |
Env factor
|
Pathway |
hsa05204 | Chemical carcinogenesis - DNA adducts |
|
Disease |
H00048 | Hepatocellular carcinoma |
H00014 | Non-small cell lung cancer |
|
Gene |
1576 | CYP3A4; cytochrome P450 family 3 subfamily A member 4 |
1544 | CYP1A2; cytochrome P450 family 1 subfamily A member 2 |
|
Perturbant |
|
Metabolite |
C19586 | Aflatoxin B1-exo-8,9-epoxide |
|
Reference |
|
Authors |
Wild CP, Turner PC |
Title |
The toxicology of aflatoxins as a basis for public health decisions. |
Journal |
|
Reference |
|
Authors |
Kobertz WR, Wang D, Wogan GN, Essigmann JM |
Title |
An intercalation inhibitor altering the target selectivity of DNA damaging agents: synthesis of site-specific aflatoxin B1 adducts in a p53 mutational hotspot. |
Journal |
|
Reference |
|
Authors |
Bailey EA, Iyer RS, Harris TM, Essigmann JM |
Title |
A viral genome containing an unstable aflatoxin B1-N7-guanine DNA adduct situated at a unique site. |
Journal |
|
Reference |
|
Authors |
Marchese S, Polo A, Ariano A, Velotto S, Costantini S, Severino L |
Title |
Aflatoxin B1 and M1: Biological Properties and Their Involvement in Cancer Development. |
Journal |
|