KEGG NETWORK: N00961

NETWORK: N00961

Entry

N00961                      Network

Name

Mutation-activated TRPC3 to mGluR1-TRPC3 signaling pathway

Definition

TRPC3* -> Ca2+

Expanded

7222v1 -> C00076

Class

nt06462 Spinocerebellar ataxia
nt06466 Pathways of neurodegeneration

Type

Variant

Pathway

hsa05017

Spinocerebellar ataxia

Disease

H00063

Spinocerebellar ataxia (SCA)

Gene

7222	TRPC3; transient receptor potential cation channel subfamily C member 3

Variant

7222v1 (TRPC3*) TRPC3 mutation

Metabolite

C00076

Calcium cation

Reference

PMID:29777722

Authors

Hisatsune C, Hamada K, Mikoshiba K

Title

Ca(2+) signaling and spinocerebellar ataxia.

Journal

Biochim Biophys Acta Mol Cell Res 1865:1733-1744 (2018)
DOI:10.1016/j.bbamcr.2018.05.009

Reference

PMID:27392710

Authors

Mark MD, Schwitalla JC, Groemmke M, Herlitze S

Title

Keeping Our Calcium in Balance to Maintain Our Balance.

Journal

Biochem Biophys Res Commun 483:1040-1050 (2017)
DOI:10.1016/j.bbrc.2016.07.020

Reference

PMID:19351902

Authors

Becker EB, Oliver PL, Glitsch MD, Banks GT, Achilli F, Hardy A, Nolan PM, Fisher EM, Davies KE

Title

A point mutation in TRPC3 causes abnormal Purkinje cell development and cerebellar ataxia in moonwalker mice.

Journal

Proc Natl Acad Sci U S A 106:6706-11 (2009)
DOI:10.1073/pnas.0810599106

All links

Pathway (1)   
   KEGG PATHWAY (1)   
Network (1)   
   KEGG VARIANT (1)   
Chemical substance (1)   
   KEGG COMPOUND (1)   
Gene (1)   
   KEGG GENES (1)   
Literature (3)   
   PubMed (3)   
All databases (7)   

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