Entry |
|
Name |
GH-Jak-STAT signaling pathway
|
Definition |
GH -> GHR -> JAK2 -> STAT5 => IGF1 |
Expanded |
(2688,2689) -> 2690 -> 3717 -> (6776,6777) => 3479 |
Class |
|
Type |
Reference
|
Pathway |
hsa04935 | Growth hormone synthesis, secretion and action |
|
Gene |
2688 | GH1; growth hormone 1 |
2689 | GH2; growth hormone 2 |
2690 | GHR; growth hormone receptor |
3717 | JAK2; Janus kinase 2 |
6776 | STAT5A; signal transducer and activator of transcription 5A |
6777 | STAT5B; signal transducer and activator of transcription 5B |
3479 | IGF1; insulin like growth factor 1 |
|
Reference |
|
Authors |
Lu M, Flanagan JU, Langley RJ, Hay MP, Perry JK |
Title |
Targeting growth hormone function: strategies and therapeutic applications. |
Journal |
|
Reference |
|
Authors |
Argetsinger LS, Carter-Su C |
Title |
Mechanism of signaling by growth hormone receptor. |
Journal |
|
Reference |
|
Authors |
Dehkhoda F, Lee CMM, Medina J, Brooks AJ |
Title |
The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects. |
Journal |
|
Reference |
|
Authors |
Carter-Su C, Rui L, Herrington J |
Title |
Role of the tyrosine kinase JAK2 in signal transduction by growth hormone. |
Journal |
|