Entry |
|
Name |
MAGI-PTEN signaling pathway
|
Definition |
MAGI -> PTEN -| PIP3 -> AKT |
Expanded |
(9223,9863) -> 5728 -| C05981 -> (207,208,10000) |
Class |
|
Type |
Reference
|
Pathway |
|
Gene |
9223 | MAGI1; membrane associated guanylate kinase, WW and PDZ domain containing 1 |
9863 | MAGI2; membrane associated guanylate kinase, WW and PDZ domain containing 2 |
5728 | PTEN; phosphatase and tensin homolog |
207 | AKT1; AKT serine/threonine kinase 1 |
208 | AKT2; AKT serine/threonine kinase 2 |
10000 | AKT3; AKT serine/threonine kinase 3 |
|
Metabolite |
C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
|
Reference |
|
Authors |
Shin K, Fogg VC, Margolis B |
Title |
Tight junctions and cell polarity. |
Journal |
|
Reference |
|
Authors |
Wu X, Hepner K, Castelino-Prabhu S, Do D, Kaye MB, Yuan XJ, Wood J, Ross C, Sawyers CL, Whang YE |
Title |
Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2. |
Journal |
|
Reference |
|
Authors |
Subauste MC, Nalbant P, Adamson ED, Hahn KM |
Title |
Vinculin controls PTEN protein level by maintaining the interaction of the adherens junction protein beta-catenin with the scaffolding protein MAGI-2. |
Journal |
|
Reference |
|
Authors |
Tolkacheva T, Boddapati M, Sanfiz A, Tsuchida K, Kimmelman AC, Chan AM |
Title |
Regulation of PTEN binding to MAGI-2 by two putative phosphorylation sites at threonine 382 and 383. |
Journal |
Cancer Res 61:4985-9 (2001) |