Entry |
|
Name |
Extrinsic apoptotic pathway
|
Definition |
TNF -> TNFRSF1A -> (RIPK1+TRADD+TRAF2/5) -> FADD -> CASP8 -> (CASP3,CASP7) |
Expanded |
7124 -> 7132 -> (8737+8717+(7186,7188)) -> 8772 -> 841 -> (836,840) |
Class |
|
Type |
Reference
|
Pathway |
|
Gene |
7124 | TNF; tumor necrosis factor |
7132 | TNFRSF1A; TNF receptor superfamily member 1A |
8737 | RIPK1; receptor interacting serine/threonine kinase 1 |
8717 | TRADD; TNFRSF1A associated via death domain |
7186 | TRAF2; TNF receptor associated factor 2 |
7188 | TRAF5; TNF receptor associated factor 5 |
8772 | FADD; Fas associated via death domain |
|
Reference |
|
Authors |
Vucic D, Dixit VM, Wertz IE |
Title |
Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death. |
Journal |
|
Reference |
|
Authors |
Beesoo R, Neergheen-Bhujun V, Bhagooli R, Bahorun T |
Title |
Apoptosis inducing lead compounds isolated from marine organisms of potential relevance in cancer treatment. |
Journal |
|
Reference |
|
Authors |
MacFarlane M, Williams AC |
Title |
Apoptosis and disease: a life or death decision. |
Journal |
|