Entry |
|
Name |
PDGF-PDGFR-PI3K signaling pathway
|
Definition |
PDGF -> PDGFR -> PI3K -> PIP3 -> AKT -> MTOR -> S6K |
Expanded |
(5154,5155) -> (5156,5159) -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> 2475 -> (6198,6199) |
Class |
|
Type |
Reference
|
Pathway |
|
Gene |
5154 | PDGFA; platelet derived growth factor subunit A |
5155 | PDGFB; platelet derived growth factor subunit B |
5156 | PDGFRA; platelet derived growth factor receptor alpha |
5159 | PDGFRB; platelet derived growth factor receptor beta |
5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
207 | AKT1; AKT serine/threonine kinase 1 |
208 | AKT2; AKT serine/threonine kinase 2 |
10000 | AKT3; AKT serine/threonine kinase 3 |
2475 | MTOR; mechanistic target of rapamycin |
6198 | RPS6KB1; ribosomal protein S6 kinase B1 |
6199 | RPS6KB2; ribosomal protein S6 kinase B2 |
|
Metabolite |
C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
|
Reference |
|
Authors |
Liu P, Cheng H, Roberts TM, Zhao JJ |
Title |
Targeting the phosphoinositide 3-kinase pathway in cancer. |
Journal |
|
Reference |
|
Authors |
Blume-Jensen P, Hunter T |
Title |
Oncogenic kinase signalling. |
Journal |
|
Reference |
|
Authors |
Wymann MP, Pirola L |
Title |
Structure and function of phosphoinositide 3-kinases. |
Journal |
|