KEGG ORTHOLOGY: K04490

ORTHOLOGY: K04490

Entry

K04490                      KO

Symbol

TCF7L1

Name

transcription factor 7-like 1

Pathway

map04310

Wnt signaling pathway

map04390

Hippo signaling pathway

map04520

Adherens junction

map04916

Melanogenesis

map04934

Cushing syndrome

map04936

Alcoholic liver disease

map05132

Salmonella infection

map05165

Human papillomavirus infection

map05167

Kaposi sarcoma-associated herpesvirus infection

map05200

Pathways in cancer

map05210

Colorectal cancer

map05213

Endometrial cancer

map05215

Prostate cancer

map05216

Thyroid cancer

map05217

Basal cell carcinoma

map05221

Acute myeloid leukemia

map05224

Breast cancer

map05225

Hepatocellular carcinoma

map05226

Gastric cancer

map05412

Arrhythmogenic right ventricular cardiomyopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K04490  TCF7L1; transcription factor 7-like 1
   04390 Hippo signaling pathway
    K04490  TCF7L1; transcription factor 7-like 1
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04490  TCF7L1; transcription factor 7-like 1
09150 Organismal Systems
  09152 Endocrine system
   04916 Melanogenesis
    K04490  TCF7L1; transcription factor 7-like 1
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04490  TCF7L1; transcription factor 7-like 1
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04490  TCF7L1; transcription factor 7-like 1
   05225 Hepatocellular carcinoma
    K04490  TCF7L1; transcription factor 7-like 1
   05226 Gastric cancer
    K04490  TCF7L1; transcription factor 7-like 1
   05216 Thyroid cancer
    K04490  TCF7L1; transcription factor 7-like 1
   05221 Acute myeloid leukemia
    K04490  TCF7L1; transcription factor 7-like 1
   05217 Basal cell carcinoma
    K04490  TCF7L1; transcription factor 7-like 1
   05215 Prostate cancer
    K04490  TCF7L1; transcription factor 7-like 1
   05213 Endometrial cancer
    K04490  TCF7L1; transcription factor 7-like 1
   05224 Breast cancer
    K04490  TCF7L1; transcription factor 7-like 1
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04490  TCF7L1; transcription factor 7-like 1
   05165 Human papillomavirus infection
    K04490  TCF7L1; transcription factor 7-like 1
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K04490  TCF7L1; transcription factor 7-like 1
  09166 Cardiovascular disease
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04490  TCF7L1; transcription factor 7-like 1
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K04490  TCF7L1; transcription factor 7-like 1
   04934 Cushing syndrome
    K04490  TCF7L1; transcription factor 7-like 1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04490  TCF7L1; transcription factor 7-like 1
Transcription factors [BR:ko03000]
Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   HMG TCF-1
    K04490  TCF7L1; transcription factor 7-like 1

Genes

HSA:	83439(TCF7L1)

PTR:	744526(TCF7L1)

PPS:	100968002(TCF7L1)

GGO:	101151621(TCF7L1)

PON:	100436197(TCF7L1)

PPYG:

129030261(TCF7L1)

NLE:	100601518(TCF7L1)

HMH:	116483590(TCF7L1)

SSYN:

129461823(TCF7L1)

MCC:	694560(TCF7L1)

MCF:	102125513(TCF7L1)

MTHB:

126933391

MNI:	105465371(TCF7L1)

CSAB:

103219950(TCF7L1)

CATY:

105587638(TCF7L1)

PANU:

101017547(TCF7L1)

TGE:	112604528(TCF7L1)

MLEU:

105528862(TCF7L1)

RRO:	104659731(TCF7L1)

RBB:	108542809(TCF7L1)

TFN:	117062119(TCF7L1)

PTEH:

111551134(TCF7L1)

CANG:

105527514(TCF7L1)

CJC:	100403963(TCF7L1)

SBQ:	101033762(TCF7L1)

CIMI:

108295686(TCF7L1)

ANAN:

105707914(TCF7L1)

CSYR:

103266761

MMUR:

105876584(TCF7L1)

LCAT:

123637116(TCF7L1)

PCOQ:

105810284(TCF7L1)

OGA:	100940553(TCF7L1)

MMU:	21415(Tcf7l1)

MCAL:

110296038(Tcf7l1)

MPAH:

110315696(Tcf7l1)

RNO:	312451(Tcf7l1)

MCOC:

116099088(Tcf7l1)

ANU:	117715247(Tcf7l1)

MUN:	110541202(Tcf7l1)

CGE:	100753225(Tcf7l1)

MAUA:

101839395(Tcf7l1) 121142589

PROB:

127235531(Tcf7l1)

PLEU:

114681591(Tcf7l1)

MORG:

121437942(Tcf7l1)

MFOT:

126493279

AAMP:

119807723(Tcf7l1)

NGI:	103739783(Tcf7l1)

HGL:	101699909(Tcf7l1)

CPOC:

100731379(Tcf7l1)

CCAN:

109686184(Tcf7l1)

DORD:

106000204(Tcf7l1)

DSP:	122116902(Tcf7l1)

PLOP:

125356229(Tcf7l1)

NCAR:

124963199

MMMA:

107159692(Tcf7l1)

OCU:

100340471

OPI:	101522406(TCF7L1)

TUP:	102481394(TCF7L1)

GVR:	103585949(TCF7L1)

CFA:	612070(TCF7L1)

CLUD:

112664304(TCF7L1)

VVP:	112916685(TCF7L1)

VLG:	121490511(TCF7L1)

NPO:	129510910(TCF7L1)

AML:	100480690(TCF7L1)

UMR:	103671448(TCF7L1)

UAH:	113243231(TCF7L1)

UAR:	123799645(TCF7L1)

ELK:

111148131

LLV:

125108462

MPUF:

101670990(TCF7L1)

MNP:	132021404(TCF7L1)

MLK:	131840380(TCF7L1)

NVS:	122915045(TCF7L1)

ORO:	101382778(TCF7L1)

EJU:	114223462(TCF7L1)

ZCA:	113938298(TCF7L1)

MLX:	118007920(TCF7L1)

NSU:	110587588(TCF7L1)

LWW:	102731685(TCF7L1)

FCA:	101089850(TCF7L1)

PYU:	121019121(TCF7L1)

PCOO:

112869689(TCF7L1)

PBG:	122497097(TCF7L1)

PVIV:

125162247(TCF7L1)

LRUF:

124503502

PTG:	102958078(TCF7L1)

PPAD:

109263707(TCF7L1)

PUC:

125937396

AJU:

106978197

HHV:	120220478(TCF7L1)

BTA:	515303(TCF7L1)

BOM:	102281039(TCF7L1)

BIU:	109565564(TCF7L1)

BBUB:

102410081(TCF7L1)

BBIS:

105004594(TCF7L1)

CHX:	102187776(TCF7L1)

OAS:	100913162(TCF7L1)

BTAX:

128056483(TCF7L1)

ODA:	120851515(TCF7L1)

CCAD:

122441729(TCF7L1)

MBEZ:

129538967(TCF7L1)

SSC:	100523899(TCF7L1)

CFR:	102516787(TCF7L1)

CBAI:

105072093(TCF7L1)

CDK:	105104146(TCF7L1)

VPC:	102525926(TCF7L1)

BACU:

103010166(TCF7L1)

BMUS:

118905868(TCF7L1)

LVE:	103069353(TCF7L1)

OOR:	101287223(TCF7L1)

DLE:	111165393(TCF7L1)

PCAD:

102974053(TCF7L1)

PSIU:

116764402(TCF7L1)

NASI:

112399043(TCF7L1)

ECB:	100067427(TCF7L1)

EPZ:	103548276(TCF7L1)

EAI:	106838609(TCF7L1)

MYB:	102240393(TCF7L1)

MYD:	102768915(TCF7L1)

MMYO:

118668800(TCF7L1)

MLF:	102417756(TCF7L1)

MDT:	132213149(TCF7L1)

PKL:	118717604(TCF7L1)

EFUS:

103299070(TCF7L1)

MNA:	107528616(TCF7L1)

DRO:	112302951(TCF7L1)

SHON:

118982463(TCF7L1) 118989528

AJM:	119059869(TCF7L1)

PDIC:

114499663(TCF7L1)

PHAS:

123811980(TCF7L1)

MMF:	118630569(TCF7L1)

PPAM:

129073949(TCF7L1)

HAI:	109371340(TCF7L1)

RFQ:	117033407(TCF7L1)

PALE:

102886093(TCF7L1)

PGIG:

120594603(TCF7L1)

PVP:	105298541(TCF7L1)

RAY:	107506285(TCF7L1)

MJV:	108405898(TCF7L1)

TOD:	119259123(TCF7L1)

SARA:

101550691(TCF7L1)

SETR:

126024487(TCF7L1)

TMU:

101341696

ETF:	101655177(TCF7L1)

DNM:	101417902(TCF7L1)

MDO:	100030368(TCF7L1)

GAS:	123233138(TCF7L1)

SHR:	100922609(TCF7L1)

AFZ:

127547432

PCW:	110196343(TCF7L1)

TVP:	118844387(TCF7L1)

OAA:	114817948(TCF7L1)

GGA:	395230(TCF7L1)

PCOC:

116231327(TCF7L1)

MGP:	104917108(TCF7L1)

CJO:	107323707(TCF7L1)

TPAI:

128090167(TCF7L1)

LMUT:

125685234(TCF7L1)

NMEL:

110387133(TCF7L1)

APLA:

101801135(TCF7L1)

ACYG:

106048886(TCF7L1)

CATA:

118260930(TCF7L1)

AFUL:

116499387(TCF7L1)

TGU:	115498209(TCF7L1)

LSR:	110478270(TCF7L1)

PMOA:

120505008(TCF7L1)

OTC:	121346667(TCF7L1)

PRUF:

121359809(TCF7L1)

GFR:	102039905(TCF7L1)

FAB:	101817952(TCF7L1)

OMA:	130261854(TCF7L1)

PHI:	102105833(TCF7L1)

PMAJ:

107213891(TCF7L1)

CCAE:

111938914(TCF7L1)

CCW:	104683181(TCF7L1)

CBRC:

103620244(TCF7L1)

ETL:	114070472(TCF7L1)

ZLE:	135456937(TCF7L1)

SVG:	106862411(TCF7L1)

MMEA:

130586305(TCF7L1)

HRT:	120764102(TCF7L1)

SATI:

136372618(TCF7L1)

FPG:	101922879(TCF7L1)

FCH:	102051021(TCF7L1)

CCRI:

104165649

SHAB:

115618453(TCF7L1)

TALA:

104362330(TCF7L1)

ACHC:

115349900(TCF7L1)

HLE:	104828923(TCF7L1)

AGEN:

126051625

GCL:

127025235

NNI:	104022615(TCF7L1)

AFOR:

103904221(TCF7L1)

CLV:	102084814(TCF7L1)

CUCA:

104067006(TCF7L1)

CPEA:

104392687(TCF7L1)

CVF:	104285063(TCF7L1)

RTD:	128919648(TCF7L1)

AAM:

106497459

AROW:

112971101(TCF7L1)

DNE:

112994866

ASN:	102382172(TCF7L1)

AMJ:	102559656(TCF7L1)

CPOO:

109324635(TCF7L1)

GGN:	109286704(TCF7L1)

PSS:	102456229(TCF7L1)

CMY:	102947844(TCF7L1)

CCAY:

125626470(TCF7L1)

DCC:	119848739(TCF7L1)

CPIC:

101943923(TCF7L1)

TST:	117872874(TCF7L1)

CABI:

116820735(TCF7L1)

MRV:	120397584(TCF7L1)

ACS:	100553130(tcf7l1)

ASAO:

132782760(TCF7L1)

PVT:	110084320(TCF7L1)

SUND:

121934613(TCF7L1)

PBI:	103066724(TCF7L1)

PMUR:

107286235(TCF7L1)

CTIG:

120313945(TCF7L1)

TSR:	106539368(TCF7L1)

PGUT:

117677059(TCF7L1)

APRI:

131203795(TCF7L1)

PTEX:

113447733(TCF7L1)

NSS:	113414485(TCF7L1)

VKO:	123027052(TCF7L1)

PMUA:

114585748(TCF7L1)

PRAF:

128402557(TCF7L1)

ZVI:	118097303(TCF7L1)

HCG:	128333530(TCF7L1)

GJA:	107117396(TCF7L1)

STOW:

125441754(TCF7L1)

EMC:	129342060(TCF7L1)

XLA:	394281(tcf7l1.S) 397863(tcf7l1.L)

XTR:	448107(tcf7l1)

NPR:

108792469

RTEM:

120933071(TCF7L1)

BBUF:

120986167(TCF7L1)

BGAR:

122929474(TCF7L1)

MUO:	115469279(TCF7L1)

GSH:	117362505(TCF7L1)

DRE:	30523(tcf7l1a) 30556(tcf7l1b)

SRX:	107721095 107746220 107747791 107758653

SANH:

107658535 107689229 107698102

SGH:	107556226 107558109 107563849 107602061

CCAR:

109061477 109065562 109094448

CAUA:

113054570 113070993 113107300 113110247

CGIB:

127963698 127965925 127966705 128018304 128020720

PTET:

122350851(tcf7l1b) 122353201(tcf7l1a) 122358150

LROH:

127169871(tcf7l1b) 127172457(tcf7l1a)

OMC:	131545540(tcf7l1b) 131548395(tcf7l1a)

PPRM:

120474207(tcf7l1a) 120481307(tcf7l1b)

RKG:	130078054(tcf7l1a) 130082133(tcf7l1b)

MAMB:

125262345(tcf7l1a) 125280430(tcf7l1b)

CIDE:

127517104 127521501

CERY:

137027367(tcf7l1b) 137029462(tcf7l1a)

MASI:

127415459 127423965 127432983 127433839

TROS:

130546223(tcf7l1a) 130568298(tcf7l1b)

TDW:	130407032(tcf7l1b) 130411805(tcf7l1a)

MANU:

129414006(tcf7l1b) 129446566(tcf7l1a)

IPU:	108265410(tcf7l1b)

IFU:	128607348(tcf7l1b)

PHYP:

113546045

SMEO:

124399623(tcf7l1b)

TFD:	113645099(tcf7l1b)

TVC:	132853353(tcf7l1b)

TRN:	134318428(tcf7l1b)

AMEX:

103022374(tcf7l1b)

CMAO:

118813135(tcf7l1b) 118824685(tcf7l1a)

EEE:	113586207 113589257

CHAR:

105902771(tcf7l1b) 105912913(tcf7l1a)

TRU:	101063163 101074632 115250984 115250985

TFS:	130516798(tcf7l1a) 130525287(tcf7l1b)

TNG:	GSTEN00011518G001 GSTEN00025415G001

LCO:	104935330 104937897

NCC:	104946533(tcf7l1)

TBEN:

117482633 117496881(tcf7l1b)

CGOB:

115013514 115016853

PGEO:

117452970(tcf7l1b)

GACU:

117556347 117561075(tcf7l1b)

EMAC:

134868341 134874085(tcf7l1b)

ELY:	117253031(tcf7l1b) 117254049 117269726

EFO:	125890368(tcf7l1b) 125905690

PLEP:

121938910 121944425(tcf7l1b)

SLUC:

116041786 116053887(tcf7l1b)

ECRA:

117944255 117959748

ESP:	116685754 116686075

PFLV:

114555040 114571186

GAT:	120831035 120831649

PPUG:

119224565(tcf7l1b) 119226883

AFB:	129100781(tcf7l1b) 129102375

CLUM:

117736417(tcf7l1b) 117740101

PSWI:

130197066(tcf7l1b) 130205718(tcf7l1a)

MSAM:

119896780 119914157 119914244

SCHU:

122865509 122876664(tcf7l1b)

CUD:	121510420 121524704

ALAT:

119019317(tcf7l1b) 119030554(tcf7l1a)

MZE:	101466461 101481605(tcf7l1)

ONL:	100692408 100693117 100698220 100705177 102075719

OAU:	116321645 116323960(tcf7l1b) 116333212 120434776 120435026 120437054 120441818 120442056

OLA:	100820729(tcf7l1) 111948314

OML:	112148818(tcf7l1b) 112162929

CSAI:

133450325(tcf7l1b)

XMA:	102218641 102234111

XCO:	114150160 114154484

XHE:	116725078 116729763

PRET:

103470543 103473136 103473327

PFOR:

103146213 103153233

PLAI:

106962954 106963692

PMEI:

106915824 106931867

GAF:	122828060(tcf7l1b) 122847224

PPRL:

129371953(tcf7l1b) 129379828

CVG:	107082304 107096394

CTUL:

119783953(tcf7l1b)

GMU:	124872815 124878390(tcf7l1b)

NFU:	107393717(tcf7l1) 107395259

KMR:	108236527(tcf7l1b) 108242566

ALIM:

106513792 106520143(tcf7l1)

NWH:	119414015 119424771

AOCE:

111577066 111579349 111586711(tcf7l1)

MCEP:

124996986 125012430(tcf7l1b)

CSEM:

103389353 103397252 103397348

POV:	109633880 109642773

SSEN:

122758446 122769535(tcf7l1b)

HHIP:

117767600(tcf7l1b) 117771319(tcf7l1a)

HSP:	118114860(tcf7l1b) 118126041(tcf7l1a)

PPLT:

128425127(tcf7l1a) 128437962(tcf7l1b)

SMAU:

118284957 118314250(tcf7l1b)

LCF:	108878678(tcf7l1b) 108895925 108900803

SDU:	111224272 111226848 111226906

SLAL:

111645025 111664452

XGL:	120805718(tcf7l1b) 120806258

HCQ:	109507825 109525057 109525541 109527933

SSCV:

125993929

SBIA:

133491088 133499396(tcf7l1b)

PEE:	133399727(tcf7l1b) 133413646

PTAO:

133475547(tcf7l1b) 133489903

BPEC:

110161575 110169813

MALB:

109954978

BSPL:

114861532(tcf7l1b) 114866425

SJO:	128364144(tcf7l1b) 128380140

SASA:

106563056 106567996 106580381 106585616

STRU:

115159747 115164508 115200136 115203917

OTW:	112220252 112230828(tcf7l1a) 112248495 112262905

OMY:	110509652(tcf7l1a) 110523432 110526333 110536043

OGO:	124006940(tcf7l1a) 124034311 124036311 124049101

ONE:	115101019 115111609 115120981 115131934

OKI:	109868277 109873955 109879721 109895902

OKE:	118374384 118385451(tcf7l1a) 118387418 118394059

SALP:

111957791 111961773 111974657

SNH:	120020954 120021019 120026317 120063242

CCLU:

121530904 121541546 121582658 121584851

ELS:	105014239 105015187

SFM:	108923598 108929514(tcf7l1)

PKI:	111837756 111857498(tcf7l1)

AANG:

118206870(tcf7l1b)

LOC:	102692120(tcf7l1)

PSPA:

121302353 121303125

ARUT:

117397962 117962397

PSEX:

120538925(tcf7l1a)

LCM:	102364488(TCF7L1)

RTP:

CPLA:

HOC:

LERI:

Reference

PMID:17143293

Authors

Arce L, Yokoyama NN, Waterman ML

Title

Diversity of LEF/TCF action in development and disease.

Journal

Oncogene 25:7492-504 (2006)
DOI:10.1038/sj.onc.1210056

Reference

PMID:1741298

Authors

Castrop J, van Norren K, Clevers H

Title

A gene family of HMG-box transcription factors with homology to TCF-1.

Journal

Nucleic Acids Res 20:611 (1992)
DOI:10.1093/nar/20.3.611

Sequence

[hsa:83439]

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (40)   
   KEGG PATHWAY (40)   
Gene (1028)   
   KEGG GENES (526)   
   KEGG MGENES (231)   
   RefGene (262)   
   OC (9)   
Literature (2)   
   PubMed (2)   
All databases (1072)   

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