Entry
Name
Encainide hydrochloride (USAN)
Formula
C22H28N2O2. HCl
Exact mass
388.1918
Mol weight
388.93
Structure
Mol file KCF file DB search
Simcomp
Neighbor
Class
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01650 Class Ic antiarrhythmic agent
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
Remark
Efficacy
Antiarrhythmic, Sodium channel blocker
Target
Pathway
hsa04261 Adrenergic signaling in cardiomyocytes
Metabolism
Enzyme: CYP2D6 [HSA:
1565 ]
Interaction
DDI search
Structure map
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303 ]
C CARDIOVASCULAR SYSTEM
C01 CARDIAC THERAPY
C01B ANTIARRHYTHMICS, CLASS I AND III
C01BC Antiarrhythmics, class Ic
C01BC08 Encainide
D03991 Encainide hydrochloride (USAN)
Drug groups [BR:br08330 ]
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01650 Class Ic antiarrhythmic agent
DG00203 Encainide
D03991 Encainide hydrochloride
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00203 Encainide
D03991 Encainide hydrochloride
Target-based classification of drugs [BR:br08310 ]
Ion channels
Voltage-gated ion channels
Sodium channels
SCN1A
D03991 Encainide hydrochloride (USAN)
SCN2A
D03991 Encainide hydrochloride (USAN)
SCN3A
D03991 Encainide hydrochloride (USAN)
SCN4A
D03991 Encainide hydrochloride (USAN)
SCN5A
D03991 Encainide hydrochloride (USAN)
SCN8A
D03991 Encainide hydrochloride (USAN)
SCN9A
D03991 Encainide hydrochloride (USAN)
SCN10A
D03991 Encainide hydrochloride (USAN)
SCN11A
D03991 Encainide hydrochloride (USAN)
Drug metabolizing enzymes and transporters [br08309.html ]
Drug metabolizing enzymes
D03991
Drug groups [BR:br08330 ]
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01650 Class Ic antiarrhythmic agent
DG00203 Encainide
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00203 Encainide
BRITE hierarchy
Other DBs
KCF data
Show ATOM 27
1 X Cl 41.7199 -19.3899
2 C8y C 32.6900 -19.6700
3 C8y C 33.8800 -18.9700
4 N1b N 31.5000 -18.9700
5 C8x C 32.6900 -21.0700
6 C1b C 33.8800 -17.5700
7 C8x C 35.1400 -19.6700
8 C5a C 30.2400 -19.6700
9 C8x C 33.8800 -21.7700
10 C1b C 35.1400 -16.8700
11 C8x C 35.1400 -21.0700
12 C8y C 29.0500 -18.9700
13 O5a O 30.2400 -21.0700
14 C1y C 36.3300 -17.5700
15 C8x C 27.8600 -19.6700
16 C8x C 29.0500 -17.6400
17 C1x C 36.3300 -18.9700
18 N1y N 37.5200 -16.8700
19 C8x C 26.6700 -19.0400
20 C8x C 27.8600 -16.9400
21 C1x C 37.5200 -19.6700
22 C1x C 38.7800 -17.5700
23 C8y C 26.6700 -17.6400
24 C1x C 38.7800 -18.9700
25 O2a O 25.3400 -16.9400
26 C1a C 24.1500 -17.6400
27 C1a C 37.5200 -15.4700
BOND 28
1 2 3 2
2 2 4 1
3 2 5 1
4 3 6 1
5 3 7 1
6 4 8 1
7 5 9 2
8 6 10 1
9 7 11 2
10 8 12 1
11 8 13 2
12 10 14 1
13 12 15 2
14 12 16 1
15 14 17 1
16 14 18 1
17 15 19 1
18 16 20 2
19 17 21 1
20 18 22 1
21 19 23 2
22 21 24 1
23 23 25 1
24 25 26 1
25 9 11 1
26 20 23 1
27 22 24 1
28 18 27 1