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2001
This article cites 12 articles, 8 of which can be accessed free at:
Journal of Virology
Activation of NF-κB by R5 and X4 Human Immunodeficiency Virus Type 1 Induces Macrophage Inflammatory Protein 1α and Tumor Necrosis Factor Alpha in Macrophages2002 •
NF-κB is a transcriptional activator that often regulates inflammatory responses. We demonstrate that human immunodeficiency virus type 1 activates nuclear localization of NF-κB in macrophages in a manner dependent upon virus strain but independent of virus replication. Through the use of an inhibitor, NF-κB activation was found to be responsible for the cytokine and chemokine induction that we recently reported.
2016 •
In vitro treatment of human monocyte/macrophages with myristoylated recombinant Nef of HIV-1 leads to the activation of MAPKs, IκB kinases and
Journal of Virology
Development and Evaluation of an Ebola Virus Glycoprotein Mucin-Like Domain Replacement System as a New Dendritic Cell-Targeting Vaccine Approach against HIV-1Currently, there are more than 38.5 million reported cases of HIV globally. To date, there is no approved vaccine for HIV-1 infection.
2007 •
2007 •
The viral protein Nef is a virulence factor that plays multiple roles during the early and late phases of human immunodeficiency virus (HIV) replication. Nef regulates the cell surface expression of critical proteins (including down-regulation of CD4 and major histocompatibility complex class I), T-cell receptor signaling, and apoptosis, inducing proapoptotic effects in uninfected bystander cells and antiapoptotic effects in infected cells. It has been proposed that Nef intersects the CD40 ligand signaling pathway in macrophages, leading to modification in the pattern of secreted factors that appear able to recruit and activate T lymphocytes, rendering them susceptible to HIV infection. There is also increasing evidence that in vitro cell treatment with Nef induces signaling effects. Exogenous Nef treatment is able to induce apoptosis in uninfected T cells, maturation in dendritic cells, and suppression of CD40-dependent immunoglobulin class switching in B cells. Previously, we repo...
2007 •
Journal of Virology
HIV-1 Induces Telomerase Activity in Monocyte-Derived Macrophages, Possibly Safeguarding One of Its Reservoirs2012 •
Monocyte-derived macrophages (MDM) are widely distributed in all tissues and organs, including the central nervous system, where they represent the main part of HIV-infected cells. In contrast to activated CD4 + T lymphocytes, MDM are resistant to cytopathic effects and survive HIV infection for a long period of time. The molecular mechanisms of how HIV is able to persist in macrophages are not fully elucidated yet. In this context, we have studied the effect of in vitro HIV-1 infection on telomerase activity (TA), telomere length, and DNA damage. Infection resulted in a significant induction of TA. This increase was directly proportional to the efficacy of HIV infection and was found in both nuclear and cytoplasmic extracts, while neither UV light-inactivated HIV nor exogenous addition of the viral protein Tat or gp120 affected TA. Furthermore, TA was not modified during monocyte-macrophage differentiation, MDM activation, or infection with vaccinia virus. HIV infection did not aff...
1999 •
Molecules
Flavonoids as Promising Antiviral Agents against SARS-CoV-2 Infection: A Mechanistic ReviewA newly diagnosed coronavirus in 2019 (COVID-19) has affected all human activities since its discovery. Flavonoids commonly found in the human diet have attracted a lot of attention due to their remarkable biological activities. This paper provides a comprehensive review of the benefits of flavonoids in COVID-19 disease. Previously-reported effects of flavonoids on five RNA viruses with similar clinical manifestations and/or pharmacological treatments, including influenza, human immunodeficiency virus (HIV), severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and Ebola, were considered. Flavonoids act via direct antiviral properties, where they inhibit different stages of the virus infective cycle and indirect effects when they modulate host responses to viral infection and subsequent complications. Flavonoids have shown antiviral activity via inhibition of viral protease, RNA polymerase, and mRNA, virus replication, and infectivity. The compounds were...
2000 •
In lymphoid tissues coinfected with Mycobacterium avium complex (MAC) and HIV-1, increased viral replication has been ob- served. This study investigates the role of MAC in perpetuating both infections through the recruitment of monocytes as potential new hosts for bacteria and HIV-1. Increased numbers of macrophages were present in the lymph nodes of patients with dual infection as compared with
Journal of Biological Chemistry
Regulation of Human Immunodeficiency Virus Type 1Gene Transcription by Nuclear Receptors in Human Brain Cells1996 •
1995 •
2005 •
Journal of Neuroimmunology
Development of a platelet-activating factor antagonist for HIV-1 associated neurocognitive disorders2009 •
AIDS Research and Human Retroviruses
HTLV Type IIIB Infection of Human Thymic Epithelial Cells: Viral Expression Correlates with the Induction of NF-kB-Binding Activity in Cells Activated by Cell Adhesion1996 •
The Journal of Immunology
Pertussis Toxin B-Oligomer Suppresses IL-6 Induced HIV-1 and Chemokine Expression in Chronically Infected U1 Cells via Inhibition of Activator Protein 12006 •
2001 •
Journal of Virology
OX40 Stimulation by gp34/OX40 Ligand Enhances Productive Human Immunodeficiency Virus Type 1 Infection2001 •
2000 •
Nuclear Medicine Communications
Pertussis toxin B-oligomer suppresses IL6 induced HIV1 and chemokine expression in chronically infected U1 cells via inhibition of activator protein2006 •
The Journal of Immunology
HIV-1 Nef Induces the Release of Inflammatory Factors from Human Monocyte/Macrophages: Involvement of Nef Endocytotic Signals and NF- B Activation2003 •
2003 •
1998 •
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2000 •
American Journal of Infectious Diseases
Molecular Mechanisms of Neurodegenerative Diseases Induced by Human Retroviruses: A Review2009 •
Nucleic Acids Research
Human immunodeficiency virus-1 Tat activates NF- B via physical interaction with I B- and p652012 •
2011 •
Journal of Virology
Regulation of Human Immunodeficiency Virus Type 1 Replication in Human T Lymphocytes by Nitric Oxide2001 •
Infection and Immunity
Pneumocystis Activates Human Alveolar Macrophage NF- B Signaling through Mannose Receptors2004 •
Journal of Virology
Partial Activation and Induction of Apoptosis in CD4+ and CD8+ T Lymphocytes by Conformationally Authentic Noninfectious Human Immunodeficiency Virus Type 12001 •
2021 •
Proceedings of the National Academy of Sciences of the United States of America
NFκB activation by modified vaccinia virus as a novel strategy to enhance neutrophil migration and HIV-specific T-cell responses2015 •
Journal of Virology
IRF-1 Is Required for Full NF- B Transcriptional Activity at the Human Immunodeficiency Virus Type 1 Long Terminal Repeat Enhancer2008 •
F1000 - Post-publication peer review of the biomedical literature
Faculty of 1000 evaluation for Dimethyl fumarate, an immune modulator and inducer of the antioxidant response, suppresses HIV replication and macrophage-mediated neurotoxicity: a novel candidate for HIV neuroprotection2012 •
1999 •
2008 •
2013 •
Biochemical and Biophysical Research Communications
Proteasome inhibitors block HIV-1 replication by affecting both cellular and viral targets2009 •
American Journal of Sports Medicine
Synergistic activation of human immunodeficiency virus type 1 promoter activity by NF-kappa B and inhibitors of deacetylases: Potential perspectives for the development of therapeutic strategies2002 •
2008 •
Scientific Reports
Impairment of T cell development and acute inflammatory response in HIV-1 Tat transgenic mice2015 •