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Macedonian Medical Review
Introduction. The main attribute of asthma is inflammation, which leads to airway remodeling, bronchial hyperreactivity and reversible or partly reversible airway obstruction. According to GINA, asthma is a chronic inflammatory disorder of the airways in which many cells play a role, in particular mast cells, eosinophils (Eo), and T lymphocytes. Many cells and mediators take part in creating the asthmatic inflammatory reaction, but eosinophils play a central role. The aim of this study was to show the values of biological inflammatory markers (IL-5 and Eo). Methods. Patients with severe asthma, 22 (73.33%) female and 8 (26.66%) male, aged 18-65 years were included in the study. The mean age was 35.30 ±9.65 years. Patients were treated with spray Beclomethasone dipropionate of 250 μg at doses from 1000 to 2000 μg/per day. Results. This study included 30 patients of the University Clinic of Pulmology and Allergology, Skopje, with confirmed bronchial asthma, treated with ICS. In all of...
The American Journal of Pathology, 2007
Macedonian Medical Review
Asthma and chronic obstructive pulmonary disease (COPD) have traditionally been viewed as distinct clinical entities. Recently, however, much attention has been focused on patients with overlapping features of both asthma and COPD: those with asthma COPD overlap syndrome (ACOS). A significant proportion of patients who present with symptoms of a chronic airways disease have features of both asthma and COPD. Several diagnostic terms, most including the word “overlap”, have been applied to such patients, and the topic has been extensively reviewed. However, there is no generally agreed term or defining features for this category of chronic airflow limitation, although a definition based upon consensus has been published for overlap in patients with existing COPD. In spite of these uncertainties, there is broad agreement that patients with features of both asthma and COPD experience frequent exacerbations, have poor quality of life, a more rapid decline in lung function and high mortal...
World Allergy Organization Journal, 2007
World Allergy Organization Journal, 2007
Journal of clinical medicine, 2018
The aim of this study was to establish whether non-atopic patients with cough variant asthma (CVA) have different pattern of response to direct bronchoconstrictors than non-atopic patients with classic asthma (CA). A total of 170 patients of both sexes with stable CVA and CA were screened for the study and 153 were included. Patients with proven atopy were not included and 17 patients with worsening of their condition or with verified bronchial obstruction during screening were excluded. All included patients performed spirometry and underwent a bronchial challenge with histamine according to long-standing protocol in our laboratory. Significantly higher frequency of bronchial hyper-responsiveness (BHR) was found in patients with CA than in patients with CVA (63.9% vs. 44.9%, respectively; < 0.05). Sensitivity was significantly lower in patients with CVA ( < 0.05), while no significant difference was found in maximal response and responsiveness. Only patients with positive cha...
World Allergy Organization Journal, 2007
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