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2019, Eye
Investigative Opthalmology & Visual Science
Clinically Relevant Immune-Cellular Metrics of Inflammation in Meibomian Gland DysfunctionThe ocular surface
TFOS DEWS II Diagnostic Methodology report2017 •
The role of the Tear Film and Ocular Surface Society (TFOS) Dry Eye Workshop (DEWS) II Diagnostic Methodology Subcommittee was 1) to identify tests used to diagnose and monitor dry eye disease (DED), 2) to identify those most appropriate to fulfil the definition of DED and its sub-classifications, 3) to propose the most appropriate order and technique to conduct these tests in a clinical setting, and 4) to provide a differential diagnosis for DED and distinguish conditions where DED is a comorbidity. Prior to diagnosis, it is important to exclude conditions that can mimic DED with the aid of triaging questions. Symptom screening with the DEQ-5 or OSDI confirms that a patient might have DED and triggers the conduct of diagnostic tests of (ideally non-invasive) breakup time, osmolarity and ocular surface staining with fluorescein and lissamine green (observing the cornea, conjunctiva and eyelid margin). Meibomian gland dysfunction, lipid thickness/dynamics and tear volume assessment a...
The British journal of ophthalmology
Revisiting the vicious circle of dry eye disease: a focus on the pathophysiology of meibomian gland dysfunction2016 •
Meibomian gland dysfunction (MGD) is the most frequent cause of dry eye disease (DED). Eyelid inflammation, microbial growth, associated skin disorders as well as potentially severe corneal complications culminate to make MGD a complex multifactorial disorder. It is probable that MGD is a heterogeneous condition arising from any combination of the following five separate pathophysiological mechanisms: eyelid inflammation, conjunctival inflammation, corneal damage, microbiological changes and DED resulting from tear film instability. The pathogenesis of both MGD and DED can be described in terms of a 'vicious circle': the underlying pathophysiological mechanisms of DED and MGD interact, resulting in a double vicious circle. The MGD vicious circle is self-stimulated by microbiological changes, which results in increased melting temperature of meibum and subsequent meibomian gland blockage, reinforcing the vicious circle of MGD. Meibomian gland blockage, dropout and inflammatio...
Translational Vision Science & Technology
The Role of Meibography in the Diagnosis of Meibomian Gland Dysfunction in Ocular Surface Diseases2019 •
Scientific Reports
Deep learning-based automatic meibomian gland segmentation and morphology assessment in infrared meibography2021 •
Meibomian glands (MG) are large sebaceous glands located below the tarsal conjunctiva and the abnormalities of these glands cause Meibomian gland dysfunction (MGD) which is responsible for evaporative dry eye disease (DED). Accurate MG segmentation is a key prerequisite for automated imaging based MGD related DED diagnosis. However, Automatic MG segmentation in infrared meibography is a challenging task due to image artifacts. A deep learning-based MG segmentation has been proposed which directly learns MG features from the training image dataset without any image pre-processing. The model is trained and evaluated using 728 anonymized clinical meibography images. Additionally, automatic MG morphometric parameters, gland number, length, width, and tortuosity assessment were proposed. The average precision, recall, and F1 score were achieved 83%, 81%, and 84% respectively on the testing dataset with AUC value of 0.96 based on ROC curve and dice coefficient of 84%. Single image segment...
Clinical and Experimental Optometry
Non‐pharmaceutical treatment options for meibomian gland dysfunction2020 •
Clinical Ophthalmology (Auckland, N.Z.)
Effectiveness and Safety of Combined Application of Three Modes of 2940-nm Erbium:YAG and 1064-nm Neodymium:YAG Lasers in Treatment of Meibomian Gland Dysfunction2021 •
Journal of Clinical Medicine
A New Modified Experimental Meibomian Gland Injury Model: Partial Loss of Gland Due to Orifice Cauterization and the Alleviating Potential of 22-Oxacalcitriol2020 •
Indian Journal of Ophthalmology
Algorithmic approach to diagnosis and management of post-refractive surgery dry eye disease2020 •
2014 •
British Journal of Ophthalmology
In vivo confocal microscopy of meibomian glands in glaucoma2013 •
Investigative Opthalmology & Visual Science
Meibography: A Japanese Perspective2018 •
Clinical and Experimental Optometry
Tear film evaluation and management in soft contact lens wear: a systematic approachOptometry and Vision Science
In Vivo Confocal Evaluation of the Ocular Surface Morpho-Functional Unit in Dry Eye2013 •
2019 •
Ophthalmic Research
Tear 1H NMR-based metabolomics application to the molecular diagnosis of aqueous tear deficiency and Meibomian gland dysfunction2020 •
Optometry and vision science : official publication of the American Academy of Optometry
Associations with Meibomian Gland Atrophy in Daily Contact Lens Wearers2015 •
2015 •
Experimental Eye Research
New insights into the morphology and function of meibomian glands2017 •
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
Comparison of the Clinical Efficacy of Topical and Systemic Azithromycin Treatment for Posterior Blepharitis2018 •
Acta ophthalmologica
Clinical impact of inflammation in dry eye disease: proceedings of the ODISSEY group meeting2017 •
2016 •
Investigative Ophthalmology & Visual Science
The TFOS International Workshop on Contact Lens Discomfort: Report of the Definition and Classification Subcommittee2013 •
Investigative Opthalmology & Visual Science
Alterations of Murine Subbasal Corneal Nerves After Environmental Dry Eye StressBritish Journal of Ophthalmology
Modern approach to the treatment of dry eye, a complex multifactorial disease: a P.I.C.A.S.S.O. board reviewInvestigative ophthalmology & visual science
The Ocular Surface in Medically Controlled Glaucoma: An In Vivo Confocal Study2016 •
The American journal of pathology
Loss of β Epithelial Sodium Channel Function in Meibomian Glands Produces Pseudohypoaldosteronism 1-Like Ocular Disease in Mice2017 •
Scientific Reports
TheraPearl Eye Mask and Blephasteam for the treatment of meibomian gland dysfunction: a randomized, comparative clinical trial2021 •
The Ocular Surface
Infrared meibography allows detection of dimensional changes in meibomian glands following intranasal neurostimulation2020 •
International Journal of Radiation Oncology*Biology*Physics
Clinical Features and Treatment Outcomes of Patients With Primary Systemic Anaplastic Large Cell Lymphoma: Report From a Single Institution in China2012 •
Ophthalmology and Therapy
A Randomized, Controlled Treatment Trial of Eyelid-Warming Therapies in Meibomian Gland Dysfunction2014 •
IP Innovative Publication Pvt. Ltd.
Meibomian gland probing in patients with meibomian gland dysfunctionIndian Journal of Clinical and Experimental Ophthalmology
Dry eye disease associated with Primary Sjogren syndrome: An update2021 •
Journal of Clinical Medicine
Morphology of Meibomian Glands in a 65-Year-Old Norwegian Population without Dry Eye Disease2022 •
Ophthalmic research
Meibomian Gland Dysfunction in Primary and Secondary Sjögren Syndrome2018 •