Papers by Angela Reiersen
Evidence-Based Child Health: A Cochrane Review Journal, 2008
ABSTRACT This is a commentary on a Cochrane review, published in this issue of EBCH, first publis... more ABSTRACT This is a commentary on a Cochrane review, published in this issue of EBCH, first published as: Hetrick SE, Merry S, McKenzie J, Sindahl R, Protctor M. Selective serotonin reuptake inhibitors (SSRIs) for depressive disorders in children and adolescents. Cochrane Database of Systematic Reviews 2007, Issue 3. Art. No.: CD004851. DOI: 10.1002/14651858.CD004851.pub2.Further information for this Cochrane review is available in this issue of EBCH in the accompanying EBCH Summary and Characteristics and Key Findings Tables. Copyright © 2008 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. The Cochrane Collaboration
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This is an open-ended pre-registration containing plans for data analysis.
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ABSTRACT. Objective: Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder... more ABSTRACT. Objective: Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder frequently co-occur. Several studies show increased risk of substance use disorders in ADHD, yet there is limited information related to how ADHD symptoms, autistic traits, and their combined effects are associated with nicotine, alcohol, and cannabis use and use disorders in the general population. Method: Cross-sectional interview and self-report questionnaire data from 3,080 young adult Australian twins (mean age 31.9 years) were used to as-sess ADHD symptoms, autistic traits, substance use, and substance use disorders. Substance use disorders—based on Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria—were assessed in the full sample as well as in those who reported substance use. Logistic regression analyses were used for comparing the associations between ADHD symptoms, autistic traits, substance use, and substance misuse af-ter conduct disorder, sex, ...
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ImportanceWidely available and affordable options for the outpatient management of COVID-19 are n... more ImportanceWidely available and affordable options for the outpatient management of COVID-19 are needed, particularly therapies that prevent hospitalization.ObjectivePerform a meta-analysis of the available randomized clinical trial evidence for fluvoxamine in the outpatient management of COVID-19.Data SourcesWorld Health Organization International Clinical Trials Registry Platform and ClinicalTrials.gov.Study SelectionCompleted outpatient trials with available results which compared fluvoxamine to placebo.Data Extraction and SynthesisWe followed the PRISMA 2020 guidelines. We extracted study details in terms of inclusion criteria, trial demographics and the pre-specified outcome of all-cause hospitalization. Risk of bias was assessed by the Cochrane Risk of Bias 2 tool. We conducted a frequentist random effects meta-analysis, as well as two sensitivity analyses using a Bayesian random effects meta-analysis with different estimates of prior probability: a weakly neutral prior (50% ch...
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Drugs, 2021
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Clinical Pharmacology & Therapeutics, 2021
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Molecular Psychiatry, 2021
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ABSTRACTSeveral medications commonly used for a number of medical conditions share a property of ... more ABSTRACTSeveral medications commonly used for a number of medical conditions share a property of functional inhibition of acid sphingomyelinase (ASM), or FIASMA. Preclinical and clinical evidence suggest that the (ASM)/ceramide system may be central to SARS-CoV-2 infection. We examined the potential usefulness of FIASMA use among patients hospitalized for severe COVID-19 in an observational multicenter retrospective study conducted at Greater Paris University hospitals. Of 2,846 adult patients hospitalized for severe COVID-19, 277 (9.7%) were taking a FIASMA medication at the time of their hospital admission. The primary endpoint was a composite of intubation and/or death. We compared this endpoint between patients taking vs. not taking a FIASMA medication in time-to-event analyses adjusted for sociodemographic characteristics and medical comorbidities. The primary analysis was a Cox regression model with inverse probability weighting (IPW). Over a mean follow-up of 9.2 days (SD=12....
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Journal of the American Academy of Child & Adolescent Psychiatry, 2018
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Journal of the American Academy of Child & Adolescent Psychiatry, 2019
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Journal of the American Academy of Child & Adolescent Psychiatry, 2019
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Scientific Reports, 2019
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Current Treatment Options in Psychiatry, 2018
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Background: Motor and vocal tics are common in childhood. The received wisdom among clinicians is... more Background: Motor and vocal tics are common in childhood. The received wisdom among clinicians is that for most children the tics are temporary, disappearing within a few months. However, that common clinical teaching is based largely on biased and incomplete data. The present study was designed to prospectively assess outcome of children with what the current nomenclature calls Persistent Tic Disorder. Methods: We identified 43 children with recent onset tics (mean tic onset 3.3 months prior to baseline study visit) by advertising in addition to clinical sources and characterized them using extensive clinical measures. At baseline, tic symptoms were mild on average (YGTSS total tic score = 17.23 ± 6.15). We re-examined 39 of these children on the 12-month anniversary of their first tic (mean 1 year + 8 days after onset). Results: We found that tic symptoms improved on a group level at the 12-month follow-up (YGTSS total tic score = 14.15 ± 6.63), more than 90% of children had no or...
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Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, 2016
Background Schizophrenia is a heterogeneous disorder that is characterized by varying levels of h... more Background Schizophrenia is a heterogeneous disorder that is characterized by varying levels of hallucinations, delusions, negative symptoms, and disorganized features. The presence and severity of neurodevelopmental precursors and premorbid psychopathology also vary among individuals. To fully understand individual patients and to sort out phenotypic heterogeneity for genetic research studies, instruments designed to collect developmental history relevant to schizophrenia may be helpful. Objective The goal was to describe a pair of self-report and parent-report instruments developed for the purpose of collecting the developmental history of patients with known or suspected schizophrenia spectrum disorders. Method Two developmental history instruments were designed for use in studies of brain morphology and cognition in schizophrenia probands and their unaffected siblings. The instruments focus mainly on motor abnormalities and other features that have been described as schizophreni...
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Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, 2014
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Development and Psychopathology, 2015
To investigate familial influences on the full range of variability in attention and activity acr... more To investigate familial influences on the full range of variability in attention and activity across adolescence, we collected maternal ratings of 339 twin pairs at ages 12, 14, and 16, and estimated the transmitted and new familial influences on attention and activity as measured by the Strengths and Weaknesses of Attention-Deficit/Hyperactivity Disorder Symptoms and Normal Behavior Scale. Familial influences were substantial for both traits across adolescence: genetic influences accounted for 54%–73% (attention) and 31%–73% (activity) of the total variance, and shared environmental influences accounted for 0%–22% of the attention variance and 13%–57% of the activity variance. The longitudinal stability of individual differences in attention and activity was largely accounted for by familial influences transmitted from previous ages. Innovations over adolescence were also partially attributable to familial influences. Studying the full range of variability in attention and activity...
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Papers by Angela Reiersen