Does lack of improvement in the first two weeks predict treatment resistance in recent-onset psyc... more Does lack of improvement in the first two weeks predict treatment resistance in recent-onset psychosis?
Gender differences in schizophrenia are well described in the literature since the beginning of t... more Gender differences in schizophrenia are well described in the literature since the beginning of the twentieth century. Differences are observed in the incidence, prevalence, age at onset, neurobiology, course, outcome, and treatment of the disorder. Taken together, they show that schizophrenia is usually more benign in females than in males. Treatment of women with schizophrenia should consider that they are more vulnerable to the side effects of antipsychotics, especially those that increase prolactin. Treatment should be initiated with low doses of antipsychotics, and these should be increased slowly according to therapeutic response. The use of antipsychotics in special situations, such as pregnancy and puerperium, is also discussed.
ResumoObjetivo: O proposito deste artigo e o de revisar varios aspectos da esquizofrenia refratar... more ResumoObjetivo: O proposito deste artigo e o de revisar varios aspectos da esquizofrenia refrataria levando em conta questoes relaciona-das a definicao, aspectos clinicos, correlatos psicobiologicos, tratamentos farmacologicos e nao farmacologicos, assim comopreditores de resposta terapeutica. Metodo: Pesquisa no Medline, assim como artigos dos autores. Resultados e Conclusoes:Pelo menos um terco dos pacientes com esquizofrenia sao refratarios a tratamento com antipsicoticos e as evidencias apontam aclozapina em monoterapia como a principal opcao nesses casos. A politerapia com antipsicoticos nao tem apoio em evidencias.Ensaios clinicos recentes mostraram que a potencializacao da clozapina com outros antipsicoticos nao e superior ao placebo.Descritores: Esquizofrenia/terapia; Revisao do uso de medicamentos; Protocolos clinicos; Acoes farmacologicas; Resultado detratamentoAbstractObjective: The aim of the present paper is to review the various aspects of refractory schizophrenia rega...
This is a case description of a patient with clozapine and ECT resistance schizophrenia with seve... more This is a case description of a patient with clozapine and ECT resistance schizophrenia with several suicide attempts. We discussed evidence-based clinical decisions to deal with such conditions.
A avaliacao da linguagem dos enfermos mentais e um valioso recurso clinico ainda pouco utilizado ... more A avaliacao da linguagem dos enfermos mentais e um valioso recurso clinico ainda pouco utilizado no trabalho dos psiquiatras. Observando nos ultimos anos um aumento de interesse pelos estudos de linguagem, os autores discutem os problemas conceituais referentes ao emprego de termos como: alteracao formal de pensamento, associacao frouxa de ideias, descarrilhamento, fugaðdeðideia etc. A seguir, os problemas metodologicos na pesquisa de linguagem sao revistos de maneira critica e o recurso de metodos linguisticos e enfatizado. A revisao termina por uma reflexao sobre a filosofia das teorias de linguagem e a sua implicacao clinica
The authors reviews the main findings of the studies of Ziprasidone regarding the issues of mecha... more The authors reviews the main findings of the studies of Ziprasidone regarding the issues of mechanisms of action, pharmacokynetics, efficacy, tolerability, safety and adverse effects.
Aproximadamente 30% dos pacientes com esquizofrenia não apresentam uma resposta satisfatória aos ... more Aproximadamente 30% dos pacientes com esquizofrenia não apresentam uma resposta satisfatória aos antipsicóticos convencionais e são considerados refratários. A medicação de escolha nesses casos é a clozapina. Tese (Doutorado).
Cognitive deficits in schizophrenia can massively impact functionality and quality of life, furth... more Cognitive deficits in schizophrenia can massively impact functionality and quality of life, furthering the importance of cognitive training. Despite the development of the field in Europe and in the United States, no programmes have been developed and tested in developing countries. Different cultural backgrounds, budget restrictions, and other difficulties may render treatment packages created in high income countries difficult for adoption by developing nations. We performed a pilot double-blind, randomized, controlled trial in order to investigate the efficacy and feasibility of an attention and memory training programme specially created in a developing nation. The intervention used simple, widely available materials, required minimal infrastructure, and was conducted in groups. The sample included seventeen stable Brazilians with schizophrenia. Sessions were conducted weekly during five months. The cognitive training group showed significant improvements in inhibitory control a...
Does lack of improvement in the first two weeks predict treatment resistance in recent-onset psyc... more Does lack of improvement in the first two weeks predict treatment resistance in recent-onset psychosis?
Gender differences in schizophrenia are well described in the literature since the beginning of t... more Gender differences in schizophrenia are well described in the literature since the beginning of the twentieth century. Differences are observed in the incidence, prevalence, age at onset, neurobiology, course, outcome, and treatment of the disorder. Taken together, they show that schizophrenia is usually more benign in females than in males. Treatment of women with schizophrenia should consider that they are more vulnerable to the side effects of antipsychotics, especially those that increase prolactin. Treatment should be initiated with low doses of antipsychotics, and these should be increased slowly according to therapeutic response. The use of antipsychotics in special situations, such as pregnancy and puerperium, is also discussed.
ResumoObjetivo: O proposito deste artigo e o de revisar varios aspectos da esquizofrenia refratar... more ResumoObjetivo: O proposito deste artigo e o de revisar varios aspectos da esquizofrenia refrataria levando em conta questoes relaciona-das a definicao, aspectos clinicos, correlatos psicobiologicos, tratamentos farmacologicos e nao farmacologicos, assim comopreditores de resposta terapeutica. Metodo: Pesquisa no Medline, assim como artigos dos autores. Resultados e Conclusoes:Pelo menos um terco dos pacientes com esquizofrenia sao refratarios a tratamento com antipsicoticos e as evidencias apontam aclozapina em monoterapia como a principal opcao nesses casos. A politerapia com antipsicoticos nao tem apoio em evidencias.Ensaios clinicos recentes mostraram que a potencializacao da clozapina com outros antipsicoticos nao e superior ao placebo.Descritores: Esquizofrenia/terapia; Revisao do uso de medicamentos; Protocolos clinicos; Acoes farmacologicas; Resultado detratamentoAbstractObjective: The aim of the present paper is to review the various aspects of refractory schizophrenia rega...
This is a case description of a patient with clozapine and ECT resistance schizophrenia with seve... more This is a case description of a patient with clozapine and ECT resistance schizophrenia with several suicide attempts. We discussed evidence-based clinical decisions to deal with such conditions.
A avaliacao da linguagem dos enfermos mentais e um valioso recurso clinico ainda pouco utilizado ... more A avaliacao da linguagem dos enfermos mentais e um valioso recurso clinico ainda pouco utilizado no trabalho dos psiquiatras. Observando nos ultimos anos um aumento de interesse pelos estudos de linguagem, os autores discutem os problemas conceituais referentes ao emprego de termos como: alteracao formal de pensamento, associacao frouxa de ideias, descarrilhamento, fugaðdeðideia etc. A seguir, os problemas metodologicos na pesquisa de linguagem sao revistos de maneira critica e o recurso de metodos linguisticos e enfatizado. A revisao termina por uma reflexao sobre a filosofia das teorias de linguagem e a sua implicacao clinica
The authors reviews the main findings of the studies of Ziprasidone regarding the issues of mecha... more The authors reviews the main findings of the studies of Ziprasidone regarding the issues of mechanisms of action, pharmacokynetics, efficacy, tolerability, safety and adverse effects.
Aproximadamente 30% dos pacientes com esquizofrenia não apresentam uma resposta satisfatória aos ... more Aproximadamente 30% dos pacientes com esquizofrenia não apresentam uma resposta satisfatória aos antipsicóticos convencionais e são considerados refratários. A medicação de escolha nesses casos é a clozapina. Tese (Doutorado).
Cognitive deficits in schizophrenia can massively impact functionality and quality of life, furth... more Cognitive deficits in schizophrenia can massively impact functionality and quality of life, furthering the importance of cognitive training. Despite the development of the field in Europe and in the United States, no programmes have been developed and tested in developing countries. Different cultural backgrounds, budget restrictions, and other difficulties may render treatment packages created in high income countries difficult for adoption by developing nations. We performed a pilot double-blind, randomized, controlled trial in order to investigate the efficacy and feasibility of an attention and memory training programme specially created in a developing nation. The intervention used simple, widely available materials, required minimal infrastructure, and was conducted in groups. The sample included seventeen stable Brazilians with schizophrenia. Sessions were conducted weekly during five months. The cognitive training group showed significant improvements in inhibitory control a...
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