Papers by Dr.Ponna` Vijaya
Ethno-med, 2009
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Planta …, 2007
Fifteen compounds, isolated from plants reputed as snake venom antidotes, belonging to different ... more Fifteen compounds, isolated from plants reputed as snake venom antidotes, belonging to different classes of natural products, were shown to protect mice to a significant degree against the lethal action of the venom of Bothrops jararaca snakes. Administration was by the oral route, one hour prior to envenomation. The substances are nitrogen-free, low-molecular-weight compounds for which some kind of biodynamic activity has previously been reported. The fact that they are mostly trivial, naturally-occurring compounds should explain why plants used as snake-bite antidotes are so widely distributed over the plant kingdom.
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Journal of …, 2008
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Current Medicinal …, 2005
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… of Ethnobiology and …, 2010
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Toxicon, 1992
Many plants are recommended in traditional medicine as active against various effects of snakebit... more Many plants are recommended in traditional medicine as active against various effects of snakebite. Few attempts have been made to investigate the veracity of these assertions in controlled experiments. Several workers, mainly Oriental, have investigated the reputation of such plants by performing in vitro and in vivo experiments in order to demonstrate whether there was any protective effect, using drugs or mixtures of drugs prepared using traditional formulae. In some studies, these extracts were administered to mice before or after treatment with different elapid or crotalid venoms. Other papers deal with selected compounds isolated from Schumanniophyton magnificum, Eclipta prostrata or Aristolochia shimadai, and their capacity to inhibit phospholipase A2 or other enzymes (e.g. ATPase) or for physiological and biochemical properties (such as effects on uterine tone or the protection of mitochondrial membranes). Japanese workers have described the antihaemorrhagic effect of persimmon tannin from Diospyros kaki. Atropine has been attributed a life-prolonging effect after black mamba venom treatment. Prolonged survival was also observed after pretreatment with extracts of Diodia scandens and Andrographis paniculata. Some authors have found little or no beneficial effects. The papers collected so far show that there are no systematic investigations in this field.
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Journal of Ethnopharmacology, 1993
A list of flowering plants used for the treatment of snakebite has been complied from a variety o... more A list of flowering plants used for the treatment of snakebite has been complied from a variety of literature sources. Details of the geographical area and parts used are given and the basis for the reputed activity discussed. Methods of testing the reputed activity of such plants are reviewed and the identity and mode of action of the chemical substances which might be responsible is discussed for some of the plants listed.
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Journal of Herbs, Spices & Medicinal Plants, 1995
A medical ethnobotanical survey of Yanadi tribes of the Chittoor District, Andhra Pradesh, India ... more A medical ethnobotanical survey of Yanadi tribes of the Chittoor District, Andhra Pradesh, India during 1990 to 1992, indicated 22 plant species commonly used as antidotes for poisonous bites. The methods of administration, techniques for confirming poisonous bites, and alternative uses od plants for protection against poisonous bites were recorded. This forms the first Medical ethnobotanical report on the Yanadi, who are specialists in catching snakes and curing snake bites in this area.
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Phytochemistry, 2000
The article surveys the substances identified in plants reputed to neutralize the effects of snak... more The article surveys the substances identified in plants reputed to neutralize the effects of snake venoms. Protective activity of many of them against the lethal action of the venom of the jararaca (Bothrops jararaca) snake was confirmed by biological assays. It was shown that all belong to chemical classes capable of interacting with macromolecular targets--receptors and enzymes. In a few cases it has been shown that exogenous natural micromolecules can mimic the biological activity of endogenous macromolecules. From the evidence presented, it can be inferred that micromolecules which neutralize the action of snake venoms mechanistically replace endogenous antitoxic serum proteins with venom neutralizing capacity such as produced by some animals.
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Papers by Dr.Ponna` Vijaya