Veterinary museology: the Turin model. In Italy, almost every academic institution where veterina... more Veterinary museology: the Turin model. In Italy, almost every academic institution where veterinary medicine is taught has a dedicated museum, mostly an anatomical one. This work is intended to give an account of the Turin veterinary museum as it is growing up after the last setting, still to be completed. The two different places making up the Museum of Veterinary Sciences show the advances in veterinary science and the parasitological collections of Perroncito.
Il Museo di Scienze Veterinarie conserva le collezioni di strumenti scientifici, beni librari e c... more Il Museo di Scienze Veterinarie conserva le collezioni di strumenti scientifici, beni librari e carte dell'omonimo Dipartimento universitario, presso cui ha sede. Il nuovo allestimento, presentato al pubblico nel maggio scorso, segue un criterio tematico e mostra preparati tassidermici di Uccelli e Mammiferi della fauna locale, un campione piuttosto ampio di ferri chirurgici di varie epoche, strumentazione del secolo scorso per la diagnostica di laboratorio, una collezione di microscopi, dai primi esemplari costruiti nell'Ottocento fino a modelli recenti.
Professor Angelo Mosso (1846-1910) was an Italian physiologist who worked in the University of Tu... more Professor Angelo Mosso (1846-1910) was an Italian physiologist who worked in the University of Turin in the second half of nineteenth century. His researches were devoted to record and measure vital and mental processes. He invented many instruments and the signals were recorded on blackened paper on kymograph. In his work Mosso had the important help of the technician Luigi Corino, whose skill allowed to obtain very precise and functional instruments. In the storage rooms of ASTUT we preserve many of these instruments together with original documents, pictures.
Cardiovascular diseases are one of the major causes of death in industrially developed countries.... more Cardiovascular diseases are one of the major causes of death in industrially developed countries. In particular, occlusive pathologies of coronary and peripheral arteries are the third cause of death in these countries. The introduction in the 1990s of endovascular techniques for percutaneous transluminal angioplasty (PTA) and eventually of the stenting procedure has dramatically modified revascularisation strategies [1]. In the last few years, the stenting technique has almost completely replaced PTA, due to the remarkably increased procedural success and fewer post-procedural complications. However, despite these relevant clinical results, the incidence of in-stent restenosis (ISR), the process of stenosis that may occur when a stent is deployed in a blood vessel, is still high, e.g. a large number of patients having received a coronary stent have an ISR ranging from 10% to 50% of all coronary stent implantations [2, 3]. In-animal pre-clinical studies and clinical trials demonstrated
Second generation of drug eluting stents (DES) has attempted to improve safety using abluminal si... more Second generation of drug eluting stents (DES) has attempted to improve safety using abluminal sirolimus drug delivery with biodegradable polymers matrix. The present preclinical study was designed to investigate the safety and efficacy profile of Abluminus™ stents (SES). This is a new coronary stent with sirolimus and biodegradable polymer matrix coated on abluminal stent and balloon surface. SES were compared with two controls: bare metal stent (BMS) and BMS + polymer coated stents (PC). All devices (40 stents) were implanted in porcine coronary arteries with primary endpoint of endothelialization at 7 days and subsequent histological and morphometric evaluations at 7, 30 and 90 days. Early endothelialization at seven days was complete in all stents. Histology at 30 days revealed minimum inflammation in all groups and increased at 90 days in PC group while it was absent at 180 days. Thirty day morphometry showed significantly reduction of neointimal area in Abluminus™ (SES 0.96±0....
Genital tracts from 15 cows with catarrhal and purulent inflammation of the uterus and uterine tu... more Genital tracts from 15 cows with catarrhal and purulent inflammation of the uterus and uterine tubes, cystic hyperplasia of the endometrium, or hydrosalpinx were evaluated by the use of scanning electron microscopy to determine epithelial changes associated with these conditions. Uterine epithelium was revealed to be easily damaged, even in the course of mild inflammation, whereas epithelium of the uterine tube was more resistant.
The aim of this study was to evaluate the long-term follow up of the Pericarbon pericardial biopr... more The aim of this study was to evaluate the long-term follow up of the Pericarbon pericardial bioprosthesis implanted in the mitral position. Between January 1985 and January 1991, 78 patients (26 males, 52 females; mean age 56.9 +/- 7.8 years) underwent isolated mitral valve replacement with a Pericarbon valve. All bioprostheses were size 29 mm and implanted by the same surgeon. Total follow up was 663.2 pt-years and it was 97% complete. Early mortality was 1.3% (1/78); two minor cerebral embolisms were observed as early complications. At 12 years the overall survival rate was 85.0 +/- and valve-related survival 93.1 +/- 3.0%; freedom from embolic events was 83.0 +/- 4.5% and from endocarditis 98.7 +/- 1.3%. Freedom from primary tissue failure was 56.8 +/- 6.6%; it was 86.3 +/- 7.5% in patients aged > 60 years and 36.8 +/- 8.2% in younger patients. There were 27 reoperations, 26 for primary tissue failure, one for endocarditis. Comparison between basal and follow up echocardiograp...
Pericardial heart valve bioprostheses have been utilized for 20 years. In spite of encouraging in... more Pericardial heart valve bioprostheses have been utilized for 20 years. In spite of encouraging initial results, long-term follow-up showed a higher incidence of structural failures and primary tissue failures than porcine bioprostheses. Pericarbon represents the newest generation of bovine pericardial bioprostheses. Aim of this study is the long-term evaluation with echocardiographic and color Doppler technique of an innovative bioprostheses, in particular, its morfological and functional characteristics. From 1985 to 1989, 78 consecutive patients (21 males, 57 females, mean age 56.5 +/- 8.16 years) underwent mitral valve replacement with Pericarbon 29, by the same operator, who preserved the mitral posterior leaflet. One month after operation, 21 of these patients underwent echo-color Doppler evaluation, in normalized hemodynamic conditions (normality ranges). In 1995, at the end of the followup, 30 of the remaining 54 patients underwent new echo-color Doppler evaluation and these ...
The Journal of thoracic and cardiovascular surgery, 1994
Among 106 patients operated on for implantation of artificial mitral chordae (expanded polytetraf... more Among 106 patients operated on for implantation of artificial mitral chordae (expanded polytetrafluoroethylene), usually associated with other traditional procedures, 82 had degenerative valve disease. Two of them had the valve replaced during the same operation because of residual regurgitation, and one patient died (1.3%) of respiratory insufficiency. Seventy-nine patients left the hospital and were followed up to 84 months. No late deaths and only one valve-related complication were reported. This occurred in a patient who required reoperation after 18 months for sudden recurrence of mitral regurgitation caused by the rupture of natural chordae, which had been shortened during the first procedure, whereas the artificial chordae had retained their function. The clinical experience confirms positive experimental data, because this technique was reliable with lasting results. Application of artificial chordae, associated with other traditional techniques, is useful to improve the re...
Chordal preservation during mitral valve replacement is thought to greatly preserve left ventricu... more Chordal preservation during mitral valve replacement is thought to greatly preserve left ventricular function. Recently a stentless mitral valve (Biocor) became available for clinical use. It is a porcine mitral valve with the entire chordal apparatus, the sewing ring being reinforced by a bovine pericardial ring and the chordae being sutured together onto two pericardial patches. During a six months period, seven patients undergoing mitral valve replacement for mitral insufficiency (four cases), mitral stenosis (two cases) or mixed lesions (one case) received a stentless mitral valve. Their mean age was 66.3 +/- 4.8. The valve was implanted by suturing the pericardial patches onto the papillary muscles and the sewing ring onto the mitral annulus. Echocardiography control immediately after surgery showed good valve function. Three valves failed after a period of seven days, seven and 12 months respectively. The valve lesions were similar and consistent with an excessive tension on t...
Veterinary museology: the Turin model. In Italy, almost every academic institution where veterina... more Veterinary museology: the Turin model. In Italy, almost every academic institution where veterinary medicine is taught has a dedicated museum, mostly an anatomical one. This work is intended to give an account of the Turin veterinary museum as it is growing up after the last setting, still to be completed. The two different places making up the Museum of Veterinary Sciences show the advances in veterinary science and the parasitological collections of Perroncito.
Il Museo di Scienze Veterinarie conserva le collezioni di strumenti scientifici, beni librari e c... more Il Museo di Scienze Veterinarie conserva le collezioni di strumenti scientifici, beni librari e carte dell'omonimo Dipartimento universitario, presso cui ha sede. Il nuovo allestimento, presentato al pubblico nel maggio scorso, segue un criterio tematico e mostra preparati tassidermici di Uccelli e Mammiferi della fauna locale, un campione piuttosto ampio di ferri chirurgici di varie epoche, strumentazione del secolo scorso per la diagnostica di laboratorio, una collezione di microscopi, dai primi esemplari costruiti nell'Ottocento fino a modelli recenti.
Professor Angelo Mosso (1846-1910) was an Italian physiologist who worked in the University of Tu... more Professor Angelo Mosso (1846-1910) was an Italian physiologist who worked in the University of Turin in the second half of nineteenth century. His researches were devoted to record and measure vital and mental processes. He invented many instruments and the signals were recorded on blackened paper on kymograph. In his work Mosso had the important help of the technician Luigi Corino, whose skill allowed to obtain very precise and functional instruments. In the storage rooms of ASTUT we preserve many of these instruments together with original documents, pictures.
Cardiovascular diseases are one of the major causes of death in industrially developed countries.... more Cardiovascular diseases are one of the major causes of death in industrially developed countries. In particular, occlusive pathologies of coronary and peripheral arteries are the third cause of death in these countries. The introduction in the 1990s of endovascular techniques for percutaneous transluminal angioplasty (PTA) and eventually of the stenting procedure has dramatically modified revascularisation strategies [1]. In the last few years, the stenting technique has almost completely replaced PTA, due to the remarkably increased procedural success and fewer post-procedural complications. However, despite these relevant clinical results, the incidence of in-stent restenosis (ISR), the process of stenosis that may occur when a stent is deployed in a blood vessel, is still high, e.g. a large number of patients having received a coronary stent have an ISR ranging from 10% to 50% of all coronary stent implantations [2, 3]. In-animal pre-clinical studies and clinical trials demonstrated
Second generation of drug eluting stents (DES) has attempted to improve safety using abluminal si... more Second generation of drug eluting stents (DES) has attempted to improve safety using abluminal sirolimus drug delivery with biodegradable polymers matrix. The present preclinical study was designed to investigate the safety and efficacy profile of Abluminus™ stents (SES). This is a new coronary stent with sirolimus and biodegradable polymer matrix coated on abluminal stent and balloon surface. SES were compared with two controls: bare metal stent (BMS) and BMS + polymer coated stents (PC). All devices (40 stents) were implanted in porcine coronary arteries with primary endpoint of endothelialization at 7 days and subsequent histological and morphometric evaluations at 7, 30 and 90 days. Early endothelialization at seven days was complete in all stents. Histology at 30 days revealed minimum inflammation in all groups and increased at 90 days in PC group while it was absent at 180 days. Thirty day morphometry showed significantly reduction of neointimal area in Abluminus™ (SES 0.96±0....
Genital tracts from 15 cows with catarrhal and purulent inflammation of the uterus and uterine tu... more Genital tracts from 15 cows with catarrhal and purulent inflammation of the uterus and uterine tubes, cystic hyperplasia of the endometrium, or hydrosalpinx were evaluated by the use of scanning electron microscopy to determine epithelial changes associated with these conditions. Uterine epithelium was revealed to be easily damaged, even in the course of mild inflammation, whereas epithelium of the uterine tube was more resistant.
The aim of this study was to evaluate the long-term follow up of the Pericarbon pericardial biopr... more The aim of this study was to evaluate the long-term follow up of the Pericarbon pericardial bioprosthesis implanted in the mitral position. Between January 1985 and January 1991, 78 patients (26 males, 52 females; mean age 56.9 +/- 7.8 years) underwent isolated mitral valve replacement with a Pericarbon valve. All bioprostheses were size 29 mm and implanted by the same surgeon. Total follow up was 663.2 pt-years and it was 97% complete. Early mortality was 1.3% (1/78); two minor cerebral embolisms were observed as early complications. At 12 years the overall survival rate was 85.0 +/- and valve-related survival 93.1 +/- 3.0%; freedom from embolic events was 83.0 +/- 4.5% and from endocarditis 98.7 +/- 1.3%. Freedom from primary tissue failure was 56.8 +/- 6.6%; it was 86.3 +/- 7.5% in patients aged > 60 years and 36.8 +/- 8.2% in younger patients. There were 27 reoperations, 26 for primary tissue failure, one for endocarditis. Comparison between basal and follow up echocardiograp...
Pericardial heart valve bioprostheses have been utilized for 20 years. In spite of encouraging in... more Pericardial heart valve bioprostheses have been utilized for 20 years. In spite of encouraging initial results, long-term follow-up showed a higher incidence of structural failures and primary tissue failures than porcine bioprostheses. Pericarbon represents the newest generation of bovine pericardial bioprostheses. Aim of this study is the long-term evaluation with echocardiographic and color Doppler technique of an innovative bioprostheses, in particular, its morfological and functional characteristics. From 1985 to 1989, 78 consecutive patients (21 males, 57 females, mean age 56.5 +/- 8.16 years) underwent mitral valve replacement with Pericarbon 29, by the same operator, who preserved the mitral posterior leaflet. One month after operation, 21 of these patients underwent echo-color Doppler evaluation, in normalized hemodynamic conditions (normality ranges). In 1995, at the end of the followup, 30 of the remaining 54 patients underwent new echo-color Doppler evaluation and these ...
The Journal of thoracic and cardiovascular surgery, 1994
Among 106 patients operated on for implantation of artificial mitral chordae (expanded polytetraf... more Among 106 patients operated on for implantation of artificial mitral chordae (expanded polytetrafluoroethylene), usually associated with other traditional procedures, 82 had degenerative valve disease. Two of them had the valve replaced during the same operation because of residual regurgitation, and one patient died (1.3%) of respiratory insufficiency. Seventy-nine patients left the hospital and were followed up to 84 months. No late deaths and only one valve-related complication were reported. This occurred in a patient who required reoperation after 18 months for sudden recurrence of mitral regurgitation caused by the rupture of natural chordae, which had been shortened during the first procedure, whereas the artificial chordae had retained their function. The clinical experience confirms positive experimental data, because this technique was reliable with lasting results. Application of artificial chordae, associated with other traditional techniques, is useful to improve the re...
Chordal preservation during mitral valve replacement is thought to greatly preserve left ventricu... more Chordal preservation during mitral valve replacement is thought to greatly preserve left ventricular function. Recently a stentless mitral valve (Biocor) became available for clinical use. It is a porcine mitral valve with the entire chordal apparatus, the sewing ring being reinforced by a bovine pericardial ring and the chordae being sutured together onto two pericardial patches. During a six months period, seven patients undergoing mitral valve replacement for mitral insufficiency (four cases), mitral stenosis (two cases) or mixed lesions (one case) received a stentless mitral valve. Their mean age was 66.3 +/- 4.8. The valve was implanted by suturing the pericardial patches onto the papillary muscles and the sewing ring onto the mitral annulus. Echocardiography control immediately after surgery showed good valve function. Three valves failed after a period of seven days, seven and 12 months respectively. The valve lesions were similar and consistent with an excessive tension on t...
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