The total number of ICDSs is indicated. Schematic representation of the ICDSs of BCG 1173P2 compa... more The total number of ICDSs is indicated. Schematic representation of the ICDSs of BCG 1173P2 compared to the other analyzed strains.<b>Copyright information:</b>Taken from "Detecting the molecular scars of evolution in the complex by analyzing interrupted coding sequences"http://www.biomedcentral.com/1471-2148/8/78BMC Evolutionary Biology 2008;8():78-78.Published online 6 Mar 2008PMCID:PMC2277376.
MP31-10 THE MOLECULAR SIGNATURE OF THE STROMA RESPONSE IN OSTEOBLASTIC BONE METASTASIS REVEALS EN... more MP31-10 THE MOLECULAR SIGNATURE OF THE STROMA RESPONSE IN OSTEOBLASTIC BONE METASTASIS REVEALS ENRICHMENT IN HAEMATOPOIETIC STEM CELL NICHE COMPONENTS Janine Hensel*, Berna € Ozdemir, Chiara Secondini, Antoinette Wetterwald, Ruth Schwaninger, Achim Fleischmann, Bern, Switzerland; Wolfgang Raffelsberger, Olivier Poch, Strasbourg, France; Mauro Delorenzi, Lausanne, Switzerland; Ramzi Temanni, Gabri van der Pluijm, Leiden, Netherlands; Marco G. Cecchini, George N. Thalmann, Bern, Switzerland
The origin of the genetic code remains enigmatic five decades after it was elucidated, although t... more The origin of the genetic code remains enigmatic five decades after it was elucidated, although there is growing evidence that the code coevolved progressively with the ribosome. A number of primordial codes were proposed as ancestors of the modern genetic code, including comma-free codes such as the RRY, RNY, or GNC codes (R = G or A, Y = C or T, N = any nucleotide), and the X circular code, an error-correcting code that also allows identification and maintenance of the reading frame. It was demonstrated previously that motifs of the X circular code are significantly enriched in the protein-coding genes of most organisms, from bacteria to eukaryotes. Here, we show that imprints of this code also exist in the ribosomal RNA (rRNA). In a large-scale study involving 133 organisms representative of the three domains of life, we identified 32 universal X motifs that are conserved in the rRNA of >90% of the organisms. Intriguingly, most of the universal X motifs are located in rRNA reg...
BackgroundTransposable elements (TE) have attracted much attention since they shape the genome an... more BackgroundTransposable elements (TE) have attracted much attention since they shape the genome and contribute to species evolution. Organisms have evolved mechanisms to control TE activity. Testis expressed 19 (Tex19) represses TE expression in mouse testis and placenta. In the human and mouse genomes, Tex19 and Secreted and transmembrane 1 (Sectm1) are neighbors but are not homologs. Sectm1 is involved in immunity and its molecular phylogeny is unknown.MethodsUsing multiple alignments of complete protein sequences (MACS), we inferred Tex19 and Sectm1 molecular phylogenies. Protein conserved regions were identified and folds were predicted. Finally, expression patterns were studied across tissues and species using RNA-seq public data and RT-PCR.ResultsWe present 2 high quality alignments of 58 Tex19 and 58 Sectm1 protein sequences from 48 organisms. First, both genes are eutherian-specific,i.e.,exclusively present in mammals except monotremes (platypus) and marsupials. Second, Tex19...
The total number of ICDSs is indicated. Schematic representation of the ICDSs of BCG 1173P2 compa... more The total number of ICDSs is indicated. Schematic representation of the ICDSs of BCG 1173P2 compared to the other analyzed strains.<b>Copyright information:</b>Taken from "Detecting the molecular scars of evolution in the complex by analyzing interrupted coding sequences"http://www.biomedcentral.com/1471-2148/8/78BMC Evolutionary Biology 2008;8():78-78.Published online 6 Mar 2008PMCID:PMC2277376.
MP31-10 THE MOLECULAR SIGNATURE OF THE STROMA RESPONSE IN OSTEOBLASTIC BONE METASTASIS REVEALS EN... more MP31-10 THE MOLECULAR SIGNATURE OF THE STROMA RESPONSE IN OSTEOBLASTIC BONE METASTASIS REVEALS ENRICHMENT IN HAEMATOPOIETIC STEM CELL NICHE COMPONENTS Janine Hensel*, Berna € Ozdemir, Chiara Secondini, Antoinette Wetterwald, Ruth Schwaninger, Achim Fleischmann, Bern, Switzerland; Wolfgang Raffelsberger, Olivier Poch, Strasbourg, France; Mauro Delorenzi, Lausanne, Switzerland; Ramzi Temanni, Gabri van der Pluijm, Leiden, Netherlands; Marco G. Cecchini, George N. Thalmann, Bern, Switzerland
The origin of the genetic code remains enigmatic five decades after it was elucidated, although t... more The origin of the genetic code remains enigmatic five decades after it was elucidated, although there is growing evidence that the code coevolved progressively with the ribosome. A number of primordial codes were proposed as ancestors of the modern genetic code, including comma-free codes such as the RRY, RNY, or GNC codes (R = G or A, Y = C or T, N = any nucleotide), and the X circular code, an error-correcting code that also allows identification and maintenance of the reading frame. It was demonstrated previously that motifs of the X circular code are significantly enriched in the protein-coding genes of most organisms, from bacteria to eukaryotes. Here, we show that imprints of this code also exist in the ribosomal RNA (rRNA). In a large-scale study involving 133 organisms representative of the three domains of life, we identified 32 universal X motifs that are conserved in the rRNA of >90% of the organisms. Intriguingly, most of the universal X motifs are located in rRNA reg...
BackgroundTransposable elements (TE) have attracted much attention since they shape the genome an... more BackgroundTransposable elements (TE) have attracted much attention since they shape the genome and contribute to species evolution. Organisms have evolved mechanisms to control TE activity. Testis expressed 19 (Tex19) represses TE expression in mouse testis and placenta. In the human and mouse genomes, Tex19 and Secreted and transmembrane 1 (Sectm1) are neighbors but are not homologs. Sectm1 is involved in immunity and its molecular phylogeny is unknown.MethodsUsing multiple alignments of complete protein sequences (MACS), we inferred Tex19 and Sectm1 molecular phylogenies. Protein conserved regions were identified and folds were predicted. Finally, expression patterns were studied across tissues and species using RNA-seq public data and RT-PCR.ResultsWe present 2 high quality alignments of 58 Tex19 and 58 Sectm1 protein sequences from 48 organisms. First, both genes are eutherian-specific,i.e.,exclusively present in mammals except monotremes (platypus) and marsupials. Second, Tex19...
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