Background: The burdens of tuberculosis (TB) and diabetes mellitus (DM) in Nigeria are high. DM o... more Background: The burdens of tuberculosis (TB) and diabetes mellitus (DM) in Nigeria are high. DM often goes unrecognized in TB patients, resulting in poorer treatment outcomes compared with TB patients only. This study set out to compare TB treatment outcomes and associated factors in TB only and TBDM patients when a collaborative care (CC) model is in place. Methods: A prospective quasi-experimental study, modeled after the World Health Organization and The Union's Collaborative Framework for Care and Control of TB and DM was carried out among TB patients in two chest clinics in Lagos state. Patients were grouped into TB only, who received the usual TB care, directly observed treatment, short course (DOTS), and TBDM, who received DOTS and CC. Data were analyzed with IBM Statistical Package for the Social Sciences, version 23.0. Chi-square and multivariate analysis determined the association between treatment success and CC. Statistical tests were calculated at 95% confidence intervals and considered significant when P value is < 0.05. Results: Of 671 participants in the study, 52 (7.7%) had DM. At TB treatment completion, there was no statistically significant difference in outcomes between TBDM and TB-only patients (P = 0.40). Patients who received CC were about 32 (OR: 31.60, 95% CI: 3.38-293), and 5 times (OR: 5.08, 95% CI: 1.35-19.17) more likely to achieve success and cure, respectively, compared to those who did not. Conclusion: Provision of CC with DOTS ensured improved TB treatment outcomes in TBDM patients. Recommendations of WHO/The Union are feasible in our setting.
Journal of Advances in Medical and Pharmaceutical Sciences
Background and Objective: Chronic or non-communicable diseases (NCDs) are rapidly emerging as lea... more Background and Objective: Chronic or non-communicable diseases (NCDs) are rapidly emerging as leading causes of morbidity and premature mortalities globally, with greater effect being felt in low and middle income nations. As poor health behaviours practised in youthful years have been implicated in developing NCDs in later years in life, It is important to understand the level of awareness of young people regarding NCDs in order to remedy any knowledge gaps and encourage healthy practices among them that will reduce the burden of these diseases in later life. This study seeks to describe the knowledge of two groups of final year students of a tertiary institution in Nigeria on the awareness and knowledge of non-communicable diseases and their risk factors. Methods: The study was designed as a cross-sectional survey at the University of Lagos, Nigeria during the 2017/2018 academic session. A sample size of 422 final year students were used with convenient stratification. Self ...
Background: Diabetes mellitus (DM) increases the risk of developing tuberculosis (TB) three-fold.... more Background: Diabetes mellitus (DM) increases the risk of developing tuberculosis (TB) three-fold. The cost of accessing care for TB-DM co-morbidity poses a significant burden on patients, as they bear both direct and indirect costs of treatment, mostly of out-of-pocket.Objective: To estimate the direct medical cost of illness in patients with TB-DM co-morbidity in two chest clinics in Lagos State.Materials and Methods: An observational study, carried out in two chest clinics in Lagos State to evaluate direct medical costs associated with TBDM co-morbidity during TB treatment. A semi structured questionnaire, pharmacy price list of drugs and an online transportation service lara.ng was employed to document and quantify prescribed medications, laboratory investigations, number of clinic attendance and attendant transportation costs.Results: Among the participants, 53.8% were females. The mean age was 50.7±9.7 years. The total direct medical and non-medical costs for TBDM management wa...
Malaria has been described as the foremost public health concern in tropical and subtropical regi... more Malaria has been described as the foremost public health concern in tropical and subtropical regions of the world, Nigeria inclusive. This survey set out to assess the knowledge, attitude and practice on the use of ITNs as a malaria preventive tool among pregnant women and to determine its level of recommendation and proper instructions given by pharmacists. Structured questionnaires were administered to pregnant women attending antenatal clinics at two selected hospitals in Alimosho Local Government Area (ALGA) of Lagos State and also to community pharmacists practicing in the same ALGA. Data was analyzed using Epi Info 2002 and Microsoft Excel. Forty eight community pharmacists and 163 pregnant women participated in the study. About 77 and 91% of pregnant women were aware of ITNs at Igando GH and the private hospital respectively. Only 11.2% and 37.5% actually used it. Majority of the pharmacists (95.8%) recommended the use of ITNs and 95% of them also gave counsel on ITN use whil...
Background: The use of generic medicines in practice is an effective pharmaceutical cost containm... more Background: The use of generic medicines in practice is an effective pharmaceutical cost containment strategy. However, prescribing of generic medicines has remained relatively moderate compared to that of innovator brands in many developing countries. To improve generic medicine utilization, there is a need to understand prescribers’ views of generic medicines and related practices. Objectives: To explore the views of intern physicians on generic medicines, generic prescription and substitution practices. Methods: This study employed qualitative methods. The study participants were intern physicians in a tertiary hospital. The participants were recruited using snowballing technique and interviews were continued until an adequate sample size was attained. The method for data collection was face-to-face individual in-depth semi-structured interviews. A total of 12 interviews were conducted. The interviews were audio recorded, transcribed using a denaturalized approach. Data anal...
American Journal of Pharmacotherapy and Pharmaceutical Sciences
Objectives: Upper respiratory tract infections (URTIs) are the most common acute RTIs that occur ... more Objectives: Upper respiratory tract infections (URTIs) are the most common acute RTIs that occur in children. Therapy addressing symptoms is recommended for URTI management. The use of antibiotics without culture and sensitivity tests is a risk factor for antimicrobial resistance. Materials and Methods: This study was set to assess the pharmacological management of URTIs in children from a tertiary institution practice. This study was conducted in Alex Ekwueme Federal University Teaching Hospital, Abakaliki Ebonyi State, Nigeria. It was a retrospective review of 275 prescriptions of medicines for URTIs in children, from January to December 2021. A systematic sampling technique was used to collect data. Data were analyzed using the Statistical Package for the Social Sciences version 28.0. Results: Of the 275 sampled URTI cases, 157 (57.1%) occurred in male children. No laboratory test was conducted for 265 (96.4%) cases. The majority (207; 75.3%) were diagnosed as non-specific URTI. ...
Background: The burdens of tuberculosis (TB) and diabetes mellitus (DM) in Nigeria are high. DM o... more Background: The burdens of tuberculosis (TB) and diabetes mellitus (DM) in Nigeria are high. DM often goes unrecognized in TB patients, resulting in poorer treatment outcomes compared with TB patients only. This study set out to compare TB treatment outcomes and associated factors in TB only and TBDM patients when a collaborative care (CC) model is in place. Methods: A prospective quasi-experimental study, modeled after the World Health Organization and The Union's Collaborative Framework for Care and Control of TB and DM was carried out among TB patients in two chest clinics in Lagos state. Patients were grouped into TB only, who received the usual TB care, directly observed treatment, short course (DOTS), and TBDM, who received DOTS and CC. Data were analyzed with IBM Statistical Package for the Social Sciences, version 23.0. Chi-square and multivariate analysis determined the association between treatment success and CC. Statistical tests were calculated at 95% confidence intervals and considered significant when P value is < 0.05. Results: Of 671 participants in the study, 52 (7.7%) had DM. At TB treatment completion, there was no statistically significant difference in outcomes between TBDM and TB-only patients (P = 0.40). Patients who received CC were about 32 (OR: 31.60, 95% CI: 3.38-293), and 5 times (OR: 5.08, 95% CI: 1.35-19.17) more likely to achieve success and cure, respectively, compared to those who did not. Conclusion: Provision of CC with DOTS ensured improved TB treatment outcomes in TBDM patients. Recommendations of WHO/The Union are feasible in our setting.
Journal of Advances in Medical and Pharmaceutical Sciences
Background and Objective: Chronic or non-communicable diseases (NCDs) are rapidly emerging as lea... more Background and Objective: Chronic or non-communicable diseases (NCDs) are rapidly emerging as leading causes of morbidity and premature mortalities globally, with greater effect being felt in low and middle income nations. As poor health behaviours practised in youthful years have been implicated in developing NCDs in later years in life, It is important to understand the level of awareness of young people regarding NCDs in order to remedy any knowledge gaps and encourage healthy practices among them that will reduce the burden of these diseases in later life. This study seeks to describe the knowledge of two groups of final year students of a tertiary institution in Nigeria on the awareness and knowledge of non-communicable diseases and their risk factors. Methods: The study was designed as a cross-sectional survey at the University of Lagos, Nigeria during the 2017/2018 academic session. A sample size of 422 final year students were used with convenient stratification. Self ...
Background: Diabetes mellitus (DM) increases the risk of developing tuberculosis (TB) three-fold.... more Background: Diabetes mellitus (DM) increases the risk of developing tuberculosis (TB) three-fold. The cost of accessing care for TB-DM co-morbidity poses a significant burden on patients, as they bear both direct and indirect costs of treatment, mostly of out-of-pocket.Objective: To estimate the direct medical cost of illness in patients with TB-DM co-morbidity in two chest clinics in Lagos State.Materials and Methods: An observational study, carried out in two chest clinics in Lagos State to evaluate direct medical costs associated with TBDM co-morbidity during TB treatment. A semi structured questionnaire, pharmacy price list of drugs and an online transportation service lara.ng was employed to document and quantify prescribed medications, laboratory investigations, number of clinic attendance and attendant transportation costs.Results: Among the participants, 53.8% were females. The mean age was 50.7±9.7 years. The total direct medical and non-medical costs for TBDM management wa...
Malaria has been described as the foremost public health concern in tropical and subtropical regi... more Malaria has been described as the foremost public health concern in tropical and subtropical regions of the world, Nigeria inclusive. This survey set out to assess the knowledge, attitude and practice on the use of ITNs as a malaria preventive tool among pregnant women and to determine its level of recommendation and proper instructions given by pharmacists. Structured questionnaires were administered to pregnant women attending antenatal clinics at two selected hospitals in Alimosho Local Government Area (ALGA) of Lagos State and also to community pharmacists practicing in the same ALGA. Data was analyzed using Epi Info 2002 and Microsoft Excel. Forty eight community pharmacists and 163 pregnant women participated in the study. About 77 and 91% of pregnant women were aware of ITNs at Igando GH and the private hospital respectively. Only 11.2% and 37.5% actually used it. Majority of the pharmacists (95.8%) recommended the use of ITNs and 95% of them also gave counsel on ITN use whil...
Background: The use of generic medicines in practice is an effective pharmaceutical cost containm... more Background: The use of generic medicines in practice is an effective pharmaceutical cost containment strategy. However, prescribing of generic medicines has remained relatively moderate compared to that of innovator brands in many developing countries. To improve generic medicine utilization, there is a need to understand prescribers’ views of generic medicines and related practices. Objectives: To explore the views of intern physicians on generic medicines, generic prescription and substitution practices. Methods: This study employed qualitative methods. The study participants were intern physicians in a tertiary hospital. The participants were recruited using snowballing technique and interviews were continued until an adequate sample size was attained. The method for data collection was face-to-face individual in-depth semi-structured interviews. A total of 12 interviews were conducted. The interviews were audio recorded, transcribed using a denaturalized approach. Data anal...
American Journal of Pharmacotherapy and Pharmaceutical Sciences
Objectives: Upper respiratory tract infections (URTIs) are the most common acute RTIs that occur ... more Objectives: Upper respiratory tract infections (URTIs) are the most common acute RTIs that occur in children. Therapy addressing symptoms is recommended for URTI management. The use of antibiotics without culture and sensitivity tests is a risk factor for antimicrobial resistance. Materials and Methods: This study was set to assess the pharmacological management of URTIs in children from a tertiary institution practice. This study was conducted in Alex Ekwueme Federal University Teaching Hospital, Abakaliki Ebonyi State, Nigeria. It was a retrospective review of 275 prescriptions of medicines for URTIs in children, from January to December 2021. A systematic sampling technique was used to collect data. Data were analyzed using the Statistical Package for the Social Sciences version 28.0. Results: Of the 275 sampled URTI cases, 157 (57.1%) occurred in male children. No laboratory test was conducted for 265 (96.4%) cases. The majority (207; 75.3%) were diagnosed as non-specific URTI. ...
Uploads
Papers