Background: The COVID-19 pandemic has had a major impact on the world's health system, includ... more Background: The COVID-19 pandemic has had a major impact on the world's health system, including Indonesia. The national health system is facing challenges with increasing cases of COVID-19. With the forecasting of COVID-19 cases, it is hoped that it can be one of the references in dealing with COVID-19 and one form of mitigation in dealing with COVID-19. Purpose: This research aims to predict COVID-19 cases in East Java Province for the coming year using the Autoregressive Integrated Moving Average (ARIMA) method based on patient data from March 2020 to January 2022. Methods: This type of research is analytic. Forecasting future COVID-19 cases using the Autoregressive Integrated Moving Average (ARIMA) method based on COVID-19 data from March 2020 to January 2022. Results: Based on the results of ARIMA analysis, the best forecasting model for confirmed cases of COVID-19 is the model (1:0:1) with AIC values (14.22672), SIC (14.33357), while for cured cases is the model (1:2: 3)...
Latar Belakang: Survei vektor leptosirosis pada lokasi KLB yang dilakukan oleh Dinas Kesehatan Ka... more Latar Belakang: Survei vektor leptosirosis pada lokasi KLB yang dilakukan oleh Dinas Kesehatan Kabupaten Bondowoso Tahun 2021 di Kecamatan Bondowoso, Kelurahan Tamansari RT/RW 13/05 menunjukkan success trap tikus sebesar 34,04%. Penelitian ini bertujuan mengetahui determinan aspek lingkungan baik lingkungan fisik maupun sosial (perilaku) yang berisiko terjadinya penularan Leptospira sp dari tikus terkonfirmasi di Kabupaten Bondowoso, Kelurahan Tamansari RT/RW 13/05 pasca KLB leptospirosis.Metode: Penelitian ini merupakan penelitian analitik observasional kuantitatif dengan desain rancang cross sectional di Kelurahan Tamansari RT.13/05 Kecamatan Bondowoso. Populasi dan sampel penelitian sebanyak 47 rumah di lokasi pasca KLB dengan mengamati empat variabel aspek lingkungan yang berisiko terjadinya penularan bakteri Leptospira sp. Data dianalisis mempergunakan software SPSS 22.0 untuk univariat, bivariat, dan multivariat dengan regresi logistik.Hasil: Hasil uji chi-square antara determ...
Background: Diabetes mellitus is metabolic disorders caused by lack of insulin production due to ... more Background: Diabetes mellitus is metabolic disorders caused by lack of insulin production due to pancreatic β cell destruction, whereas in gestational diabetics has been an increase of hormone estrogen causing insulin resistance. Oral candidiasis is fungal opportunistic infection due to immune system decreasing and reported that oral candidiasis is one problem in diabetics people including gestational diabetic. Purpose: To determine the severity of oral candidiasis in female Wistar rats with type 1 and gestational diabetes mellitus. Methods: This research is laboratory experiment with the post test only group control design, using female Wistar rats were divided into group 1 was diabetic non-pregnant rats, group 2 was diabetic pregnant rats induced by streptozotocin and control group was normal female rats. Diabetes induction using 40 mg/kgBW streptozotocin administrated intraperitoneally. Diabetes mellitus rat categorized if blood glucose level ≥ 120 mg/dL. All group exposed with 0...
Background: One of the benign salivary gland tumors is Warthin’s tumor, which is a benign tumor c... more Background: One of the benign salivary gland tumors is Warthin’s tumor, which is a benign tumor consisting of a papillary cystic structure covered by a double epithelial layer cells and lymphoid stroma with germinal center. Several cases have reported the Warthin’s tumor transformation into a malignant tumor such as lymphoma that develops from their stromal. Expression of cytotoxic T-lymphocyte antigen 4 (CTLA-4) as part of the immune checkpoint when highly expressed leads to a more rapid development or progression of tumors. Purpose: To analyze CTLA-4 expression in Warthin’s tumors associated with the pathogenesis of its growth through an escape mechanism from immune checkpoints and analyze based on CTLA expression whether this marker has the potential to be used as immunotherapy by administering anti CTLA-4. Methods: The tissue sections slides of Warthin’s tumor (n=8) were stained with Hematoxylin Eosin and immunostained with Recombinant Anti-CTLA4 antibody [CAL49] (ab237712). The...
At the beginning of the growth, tooth inclination is mesioangular, then move gradually to come in... more At the beginning of the growth, tooth inclination is mesioangular, then move gradually to come into contact with thedistal surface of the second molar and further commit to sliding movement parallel to second molar axis. This positionwill be retained to achieve the eruption way to oral cavity. However, the last decade reported incidence increasedimpaction of the third molar teeth in the lower jaw. This study was aimed to study the level of pre-eruption of mandibularthird molar in the population group aged 14-17 years to predict the risk of tooth impaction or not. Differentiatedpopulations on cluster I, age 14-15 years old; group II, 15.1-16 years old; and group III 16.1-17 years old. Researchcarried out by clinical observation and measurement of at Department of Radiology in Jember University with 48people selected based on predetermined criteria. X-ray projection was exposed by paralleling technique on the lowerthird molar teeth, left and right. The results showed 43.75% of 14-15 y...
Latar Belakang: Diabetes Mellitus (DM) disebabkan oleh terganggunya metabolisme karbohidrat, prot... more Latar Belakang: Diabetes Mellitus (DM) disebabkan oleh terganggunya metabolisme karbohidrat, protein, dan lemak akibat kerusakan pada sel β pankreas atau terjadi resistensi insulin. Kondisi tersebut dapat mengakibatkan terjadinya penurunan berat badan serta hiperglikemia atau peningkatan kadar glukosa darah (KGD) melebihi normal. Hiperglikemia akan meningkatkan produksi advanced glycation end (AGEs) yang mengakibatkan berbagai komplikasi sistemik maupun lokal. Jintan hitam (Nigella sativa L.) memiliki kandungan bahan aktif thymoquinone (TQ) sebagai anti-diabetik yang dapat menurunkan KGD dan regenerasi pada sel β pankreas. Tujuan Penelitian: Mengetahui efektivitas ekstrak TQ jintan hitam terhadap kadar glukosa darah dan berat badan pada tikus diabetes. Materi dan Metode: 18 ekor tikus wistar jantan diinduksi diabetes dengan injeksi intravena streptozotocin (STZ) dosis 50 mg/kg BB tikus. Hari ke-1 pasca injeksi, tikus dengan KGD acak ≥ 250 mg/dl dibagi menjadi tiga kelompok (K, P1 da...
Background: Tooth loss can disrupt the mastication process. Mastication disorders limit the amoun... more Background: Tooth loss can disrupt the mastication process. Mastication disorders limit the amount of food a person consumes, affecting nutrition. The number of functional tooth units (FTUs) can affect nutritional status, measured using the body mass index (BMI). Purpose: The purpose of this study is to analyse the effect of the number of FTUs on the BMI in the elderly. Methods: This research was conducted in four villages in the Jember Regency. The number of subjects was 189, aged 45 years and over. The number of FTUs was calculated based on the anterior and posterior teeth that have contact with the antagonist and the BMI using the BMI formula. The data was analysed using a linear regression test; the level of significance is 0.005. Results: A simple linear regression test showed that there was significant correlation between FTU and BMI (p=0.366). Conclusion: The number of FTUs affects BMI; the higher the number of FTUs, the greater the BMI.
Diabetes mellitus is a chronic metabolic disease characterized by hyperglicemia caused by pancrea... more Diabetes mellitus is a chronic metabolic disease characterized by hyperglicemia caused by pancreatic insulin production deficiency or ineffectiveness insulin produced. The objective was to determine the effect of fetal tooth germ growth and development disturbance due to diabetic during pregnancy. Five pregnant rats were induced by diabetes using 40 mg/kg b.w streptozotocin intraperitonealy and five pregnant normal rats as a control group. Pregnant rats with blood glucose level ≥ 200 mg/dl considered as diabetes. Blood glucose level was measured before, after induction, and just after birth. One rat offspring sample taken from each pregnant rats using simple random sampling and euthanized on 1 day postnatal. Rat offspring right maxilla taken to observe tooth germ growth and development. Paraffin-embedded tissue cut 4μm in thickness and stained using Haematoxylin-Eosin, Mallory’s Trichrome and insulin-like growth factor 1 (IGF-1) Immunohistochemistry staining. Rat offspring who born ...
Objective: Podoplanin, a known lymphatic endothelial cell marker, has been reported to be express... more Objective: Podoplanin, a known lymphatic endothelial cell marker, has been reported to be expressed in various types of cancer. To elucidate the expression of podoplanin in precancerous lesions, we examined the immunohistochemical profiles of podoplanin in oral squamous epithelial lesions. Method: We studied a total of 298 foci of squamous cell carcinoma (SCC), carcinoma in situ (CIS), epithelial dysplasia, and hyperplastic and/or normal epithelial lesions by immunohistochemistry using D2-40. Results: There was no positivity for podoplanin in normal or hyperplastic epithelia, while all of the CIS and SCC foci stained positive. Approximately one third of the mild dysplasia foci (10 of 36 foci, 28%) and 80% of moderate dysplasia foci (78/98) showed grade 1 positive reactions (positive only in the 1st layer). Grade 2 reactions (up to 4th layer) were seen in 4 of 98 moderate dysplasia foci (4%), 29 of 74 CIS foci (39%), and 3 of 30 SCC foci (10%). Grade 3 reactions (to more than 5th lay...
Background: Pleomorphic adenoma (PA) is a benign salivary gland tumour with high incidence and re... more Background: Pleomorphic adenoma (PA) is a benign salivary gland tumour with high incidence and recurrence after treatment. It may recur with the same appearance or develop toward malignancy, namely as carcinoma ex pleomorphic adenoma (CXPA). Howthis tumour can transform into a CXPA remains unclear. Purpose: The aim of this study was to analyse the possibility of pathogenesis and progressivity of PA to CXPA. Methods: Twenty-four samples of PA and three control samples of CXPA were stained with haematoxylin and eosin (HE), Mallory’s trichrome, and Periodic acid–Schiff (PAS). All of the PA cases were identified through different kinds of stroma, tumour cells types, morphologic patterns, or else through atypical appearance of the PA similar to the CXPA. Results: Twenty-four samples of PA demonstrated that the most dominant stroma was myxofibrous, and the dominant tumour cell type was plasmacytoid cells with a trabecular pattern. Additionally, in the pleomorphic histological picture of a...
Nerve sheath myxoma is a rare benign tumor of nerve sheath origin that typi cally presents as a ... more Nerve sheath myxoma is a rare benign tumor of nerve sheath origin that typi cally presents as a small solitary skin nodule and rarely affects the oral cavity. A case of nerve sheath myxoma of the tongue in a 51yearold male is reported. The patient had a painless submucosal nodule in the lateral margin of the tongue for several months. The tumor was surgically removed under local anesthesia. Histopathologically, the removed tumor consisted of several loosely textured myxofibrous nodules in which spindle or stellateshaped cells with eosinophilic cytoplasm and hyperchromatic nuclei were scattered. Immunohistochemically, the myxoid stroma was strongly positive for perlecan, a basement membrane type heparan sulfate proteoglycan, and the tumor cells were individually circumscribed by type IV collagenpositive fibers. In addition, the tumor cells were strongly positive for vimentin, S100 protein, neuron specific enolase, and cathepsin D. However, they were not positive for epithelia...
Background: The COVID-19 pandemic has had a major impact on the world's health system, includ... more Background: The COVID-19 pandemic has had a major impact on the world's health system, including Indonesia. The national health system is facing challenges with increasing cases of COVID-19. With the forecasting of COVID-19 cases, it is hoped that it can be one of the references in dealing with COVID-19 and one form of mitigation in dealing with COVID-19. Purpose: This research aims to predict COVID-19 cases in East Java Province for the coming year using the Autoregressive Integrated Moving Average (ARIMA) method based on patient data from March 2020 to January 2022. Methods: This type of research is analytic. Forecasting future COVID-19 cases using the Autoregressive Integrated Moving Average (ARIMA) method based on COVID-19 data from March 2020 to January 2022. Results: Based on the results of ARIMA analysis, the best forecasting model for confirmed cases of COVID-19 is the model (1:0:1) with AIC values (14.22672), SIC (14.33357), while for cured cases is the model (1:2: 3)...
Latar Belakang: Survei vektor leptosirosis pada lokasi KLB yang dilakukan oleh Dinas Kesehatan Ka... more Latar Belakang: Survei vektor leptosirosis pada lokasi KLB yang dilakukan oleh Dinas Kesehatan Kabupaten Bondowoso Tahun 2021 di Kecamatan Bondowoso, Kelurahan Tamansari RT/RW 13/05 menunjukkan success trap tikus sebesar 34,04%. Penelitian ini bertujuan mengetahui determinan aspek lingkungan baik lingkungan fisik maupun sosial (perilaku) yang berisiko terjadinya penularan Leptospira sp dari tikus terkonfirmasi di Kabupaten Bondowoso, Kelurahan Tamansari RT/RW 13/05 pasca KLB leptospirosis.Metode: Penelitian ini merupakan penelitian analitik observasional kuantitatif dengan desain rancang cross sectional di Kelurahan Tamansari RT.13/05 Kecamatan Bondowoso. Populasi dan sampel penelitian sebanyak 47 rumah di lokasi pasca KLB dengan mengamati empat variabel aspek lingkungan yang berisiko terjadinya penularan bakteri Leptospira sp. Data dianalisis mempergunakan software SPSS 22.0 untuk univariat, bivariat, dan multivariat dengan regresi logistik.Hasil: Hasil uji chi-square antara determ...
Background: Diabetes mellitus is metabolic disorders caused by lack of insulin production due to ... more Background: Diabetes mellitus is metabolic disorders caused by lack of insulin production due to pancreatic β cell destruction, whereas in gestational diabetics has been an increase of hormone estrogen causing insulin resistance. Oral candidiasis is fungal opportunistic infection due to immune system decreasing and reported that oral candidiasis is one problem in diabetics people including gestational diabetic. Purpose: To determine the severity of oral candidiasis in female Wistar rats with type 1 and gestational diabetes mellitus. Methods: This research is laboratory experiment with the post test only group control design, using female Wistar rats were divided into group 1 was diabetic non-pregnant rats, group 2 was diabetic pregnant rats induced by streptozotocin and control group was normal female rats. Diabetes induction using 40 mg/kgBW streptozotocin administrated intraperitoneally. Diabetes mellitus rat categorized if blood glucose level ≥ 120 mg/dL. All group exposed with 0...
Background: One of the benign salivary gland tumors is Warthin’s tumor, which is a benign tumor c... more Background: One of the benign salivary gland tumors is Warthin’s tumor, which is a benign tumor consisting of a papillary cystic structure covered by a double epithelial layer cells and lymphoid stroma with germinal center. Several cases have reported the Warthin’s tumor transformation into a malignant tumor such as lymphoma that develops from their stromal. Expression of cytotoxic T-lymphocyte antigen 4 (CTLA-4) as part of the immune checkpoint when highly expressed leads to a more rapid development or progression of tumors. Purpose: To analyze CTLA-4 expression in Warthin’s tumors associated with the pathogenesis of its growth through an escape mechanism from immune checkpoints and analyze based on CTLA expression whether this marker has the potential to be used as immunotherapy by administering anti CTLA-4. Methods: The tissue sections slides of Warthin’s tumor (n=8) were stained with Hematoxylin Eosin and immunostained with Recombinant Anti-CTLA4 antibody [CAL49] (ab237712). The...
At the beginning of the growth, tooth inclination is mesioangular, then move gradually to come in... more At the beginning of the growth, tooth inclination is mesioangular, then move gradually to come into contact with thedistal surface of the second molar and further commit to sliding movement parallel to second molar axis. This positionwill be retained to achieve the eruption way to oral cavity. However, the last decade reported incidence increasedimpaction of the third molar teeth in the lower jaw. This study was aimed to study the level of pre-eruption of mandibularthird molar in the population group aged 14-17 years to predict the risk of tooth impaction or not. Differentiatedpopulations on cluster I, age 14-15 years old; group II, 15.1-16 years old; and group III 16.1-17 years old. Researchcarried out by clinical observation and measurement of at Department of Radiology in Jember University with 48people selected based on predetermined criteria. X-ray projection was exposed by paralleling technique on the lowerthird molar teeth, left and right. The results showed 43.75% of 14-15 y...
Latar Belakang: Diabetes Mellitus (DM) disebabkan oleh terganggunya metabolisme karbohidrat, prot... more Latar Belakang: Diabetes Mellitus (DM) disebabkan oleh terganggunya metabolisme karbohidrat, protein, dan lemak akibat kerusakan pada sel β pankreas atau terjadi resistensi insulin. Kondisi tersebut dapat mengakibatkan terjadinya penurunan berat badan serta hiperglikemia atau peningkatan kadar glukosa darah (KGD) melebihi normal. Hiperglikemia akan meningkatkan produksi advanced glycation end (AGEs) yang mengakibatkan berbagai komplikasi sistemik maupun lokal. Jintan hitam (Nigella sativa L.) memiliki kandungan bahan aktif thymoquinone (TQ) sebagai anti-diabetik yang dapat menurunkan KGD dan regenerasi pada sel β pankreas. Tujuan Penelitian: Mengetahui efektivitas ekstrak TQ jintan hitam terhadap kadar glukosa darah dan berat badan pada tikus diabetes. Materi dan Metode: 18 ekor tikus wistar jantan diinduksi diabetes dengan injeksi intravena streptozotocin (STZ) dosis 50 mg/kg BB tikus. Hari ke-1 pasca injeksi, tikus dengan KGD acak ≥ 250 mg/dl dibagi menjadi tiga kelompok (K, P1 da...
Background: Tooth loss can disrupt the mastication process. Mastication disorders limit the amoun... more Background: Tooth loss can disrupt the mastication process. Mastication disorders limit the amount of food a person consumes, affecting nutrition. The number of functional tooth units (FTUs) can affect nutritional status, measured using the body mass index (BMI). Purpose: The purpose of this study is to analyse the effect of the number of FTUs on the BMI in the elderly. Methods: This research was conducted in four villages in the Jember Regency. The number of subjects was 189, aged 45 years and over. The number of FTUs was calculated based on the anterior and posterior teeth that have contact with the antagonist and the BMI using the BMI formula. The data was analysed using a linear regression test; the level of significance is 0.005. Results: A simple linear regression test showed that there was significant correlation between FTU and BMI (p=0.366). Conclusion: The number of FTUs affects BMI; the higher the number of FTUs, the greater the BMI.
Diabetes mellitus is a chronic metabolic disease characterized by hyperglicemia caused by pancrea... more Diabetes mellitus is a chronic metabolic disease characterized by hyperglicemia caused by pancreatic insulin production deficiency or ineffectiveness insulin produced. The objective was to determine the effect of fetal tooth germ growth and development disturbance due to diabetic during pregnancy. Five pregnant rats were induced by diabetes using 40 mg/kg b.w streptozotocin intraperitonealy and five pregnant normal rats as a control group. Pregnant rats with blood glucose level ≥ 200 mg/dl considered as diabetes. Blood glucose level was measured before, after induction, and just after birth. One rat offspring sample taken from each pregnant rats using simple random sampling and euthanized on 1 day postnatal. Rat offspring right maxilla taken to observe tooth germ growth and development. Paraffin-embedded tissue cut 4μm in thickness and stained using Haematoxylin-Eosin, Mallory’s Trichrome and insulin-like growth factor 1 (IGF-1) Immunohistochemistry staining. Rat offspring who born ...
Objective: Podoplanin, a known lymphatic endothelial cell marker, has been reported to be express... more Objective: Podoplanin, a known lymphatic endothelial cell marker, has been reported to be expressed in various types of cancer. To elucidate the expression of podoplanin in precancerous lesions, we examined the immunohistochemical profiles of podoplanin in oral squamous epithelial lesions. Method: We studied a total of 298 foci of squamous cell carcinoma (SCC), carcinoma in situ (CIS), epithelial dysplasia, and hyperplastic and/or normal epithelial lesions by immunohistochemistry using D2-40. Results: There was no positivity for podoplanin in normal or hyperplastic epithelia, while all of the CIS and SCC foci stained positive. Approximately one third of the mild dysplasia foci (10 of 36 foci, 28%) and 80% of moderate dysplasia foci (78/98) showed grade 1 positive reactions (positive only in the 1st layer). Grade 2 reactions (up to 4th layer) were seen in 4 of 98 moderate dysplasia foci (4%), 29 of 74 CIS foci (39%), and 3 of 30 SCC foci (10%). Grade 3 reactions (to more than 5th lay...
Background: Pleomorphic adenoma (PA) is a benign salivary gland tumour with high incidence and re... more Background: Pleomorphic adenoma (PA) is a benign salivary gland tumour with high incidence and recurrence after treatment. It may recur with the same appearance or develop toward malignancy, namely as carcinoma ex pleomorphic adenoma (CXPA). Howthis tumour can transform into a CXPA remains unclear. Purpose: The aim of this study was to analyse the possibility of pathogenesis and progressivity of PA to CXPA. Methods: Twenty-four samples of PA and three control samples of CXPA were stained with haematoxylin and eosin (HE), Mallory’s trichrome, and Periodic acid–Schiff (PAS). All of the PA cases were identified through different kinds of stroma, tumour cells types, morphologic patterns, or else through atypical appearance of the PA similar to the CXPA. Results: Twenty-four samples of PA demonstrated that the most dominant stroma was myxofibrous, and the dominant tumour cell type was plasmacytoid cells with a trabecular pattern. Additionally, in the pleomorphic histological picture of a...
Nerve sheath myxoma is a rare benign tumor of nerve sheath origin that typi cally presents as a ... more Nerve sheath myxoma is a rare benign tumor of nerve sheath origin that typi cally presents as a small solitary skin nodule and rarely affects the oral cavity. A case of nerve sheath myxoma of the tongue in a 51yearold male is reported. The patient had a painless submucosal nodule in the lateral margin of the tongue for several months. The tumor was surgically removed under local anesthesia. Histopathologically, the removed tumor consisted of several loosely textured myxofibrous nodules in which spindle or stellateshaped cells with eosinophilic cytoplasm and hyperchromatic nuclei were scattered. Immunohistochemically, the myxoid stroma was strongly positive for perlecan, a basement membrane type heparan sulfate proteoglycan, and the tumor cells were individually circumscribed by type IV collagenpositive fibers. In addition, the tumor cells were strongly positive for vimentin, S100 protein, neuron specific enolase, and cathepsin D. However, they were not positive for epithelia...
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