Hoe-Han Goh
I'm a research fellow at INBIOSIS, UKM where my research interests are in the field of plant molecular biology and functional genomics for crop improvement and molecular discovery, particularly on plant development, secondary metabolites and phytonutrients.I'm looking for opportunity for collaborative research with like-minded researchers from around the world.
Address: Bangi, Selangor, Malaysia
Address: Bangi, Selangor, Malaysia
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Papers by Hoe-Han Goh
Here, I focus on the largest subgroup of expansins (EXPA) to identify which genes are expressed during different stages of leaf development in Arabidopsis. This information was used to design an inducible artificial microRNA construct to target the knock-down of multiple expansin genes expressed during early leaf development. Through a series of experiments knocking down expansin gene expression at different stages of leaf development, I show that the suppression of expansin gene expression at later stages of leaf development is sufficient to repress leaf growth and alter leaf shape. This molecular genetic approach is combined with an atomic force microscopy (AFM) approach to investigate the role of cell wall mechanics in leaf growth. I describe the use of AFM for probing the leaf primordium mechanics and outline consideration for future work.