Hot and humid countries such as Indonesia have a higher prevalence of acne vulgaris (AV). The act... more Hot and humid countries such as Indonesia have a higher prevalence of acne vulgaris (AV). The activity of skin microbes, not only Cutibacterium acnes, contribute to the formation of AV. Topical and oral antibiotics are routinely prescribed to treat AV. As antimicrobial resistance rates increase globally, there are concerns about decreased efficacy. This study intends to systematically evaluate the microbiomes isolated from AV lesions and their antibiotics susceptibility in Indonesia. The data were retrieved through PubMed, EMBASE, Google Scholar, and ScienceDirect searches for articles published until July 2022 using three multiword searches. Sixteen studies published between 2001 and 2022 were identified from which the data were pooled using a random effects model. The pooled prevalence estimates demonstrated that C. acnes, Staphylococcus epidermidis, and Staphylococcus aureus were the three common microbes associated with AV in Indonesia. Tetracyclines had lower resistance rates c...
: Stem cells are known for their extraordinary properties, mainly their potency, self-renewal, an... more : Stem cells are known for their extraordinary properties, mainly their potency, self-renewal, and clonality. In recent years, we have witnessed notable advancements in the field of cell therapy. Due to its remarkable properties and versatility, this cutting-edge therapy has now become a potentially promising cure for many diseases. Stem cell-based therapies have been utilized to treat various dermatological conditions, for instance, autoimmune skin disorders, atopic dermatitis, skin aging, wound healing, scar treatment, and many others. This article aims to serve as an overview of the current application of cell-based therapy in the field of dermatology.
Open Access Macedonian Journal of Medical Sciences
BACKGROUND: Dermatological emergency is a condition requiring immediate identification and treatm... more BACKGROUND: Dermatological emergency is a condition requiring immediate identification and treatment to reduce mortality and morbidity. There are several dermatoses resulting in emergency room (ER) visits frequently demonstrated by the geriatric population. However, there is a lack of data about elderly with dermatological presentation seen at the ER in Indonesia. AIM: This retrospective study aims to identify the prevalence of dermatological emergency cases in the elderly at three national referral hospitals in Indonesia within 3 years. METHODS: The sample was geriatric patients who came and/or were consulted by the ER to dermatology and venereology (DV) department. The data (e.g., age, sex, history taking, physical findings, and diagnoses) were collected from medical record from each hospital and presented as a descriptive data. RESULTS: This study showed that there were only 37% of all geriatric emergency dermatological consultations from 2017 to 2020. CONCLUSION: This study conc...
Diabetes melitus tipe 2 (DMT2) merupakan penyakit metabolik yang disebabkan oleh peningkatan resi... more Diabetes melitus tipe 2 (DMT2) merupakan penyakit metabolik yang disebabkan oleh peningkatan resistensi insulin, penurunan produksi insulin, atau kombinasi keduanya yang ditandai dengan hiperglikemia. Kelainan kulit kering termasuk salah satu manifestasi DMT2 dengan prevalensi tertinggi, yaitu 69%. Kondisi kulit kering, terutama pada kaki, berpotensi menjadi derajat yang lebih berat dan dapat berkembang menjadi ulkus kaki diabetes. Penanganan dini diperlukan untuk mencegah terjadinya penyulit dan peningkatan morbiditas pada penyandang DM. Kelainan kulit kering berkorelasi erat dengan pengontrolan glikemik yang buruk. Pada kondisi hiperglikemia dapat terjadi berbagai gangguan homeostasis kulit. Selain itu, faktor yang berkontribusi pada kelainan kulit kering adalah akumulasi advanced glycation end product (AGEs), kerusakan vaskular yang progresif, faktor neural, dan sistem imun. Etiopatogenesis kulit kering pada DMT2 meliputi berbagai hal, yaitu mekanisme terjadinya kulit kering seca...
Background: The effectiveness of Isotretinoin is superior compared to other acne therapies, parti... more Background: The effectiveness of Isotretinoin is superior compared to other acne therapies, particularly in reducing acne lesion counts. Concerns, however, arise relating the most optimal dosage regimen with the best efficacy and lesser side effect Objective: We intend to review existing randomized controlled comparative studies of isotretinoin in different regimens Methods: PubMed, Cochrane, Scopus, and ScienceDirect were searched. The inclusion criteria is RCT article. Full-text reading excluded articles that did not use GAGS as the method of measurement. The Out of 921 articles electronically searched, 6 RCTs were extracted and summarized descriptively. After full-text reading, 4 RCTs were included. We then conducted risk of bias assessments for the selected studies using The Cochrane Risk of Bias Tool. Results: Across all trials, low-dose regimens were preferable in all types of acne—owing to its similar efficacy to conventional dose but with fewer occurrence of side effects as ...
Photoaging can significantly contribute to lower quality of life. Medium-deep peeling using trich... more Photoaging can significantly contribute to lower quality of life. Medium-deep peeling using trichloroacetic acid allows controlled keratocoagulation through the dermis and into the dermal papillary layer that is effective for skin rejuvenation. The purpose of this article is to give updates regarding the efficacy, possible adverse events, and patient satisfaction of trichloroacetic acid (TCA) peeling for skin rejuvenation by assessing various photoaging parameters. A systematic review of prospective trial articles collected from PubMed, MEDLINE, EMBASE, Cochrane, and Scopus databases was conducted on November 2, 2020. Treatment efficacy was assessed based on the photoaging parameters used by each study. Adverse events and patient satisfaction as the secondary outcome were assessed based on patients-perceived improvements. Five studies included three randomized comparison studies and two prospective cohort studies. These studies show that TCA peeling significantly improve the cosmesi...
Pruritus merupakan sensasi tidak nyaman yang mencetuskan keinginan untuk menggaruk. Sensasi terse... more Pruritus merupakan sensasi tidak nyaman yang mencetuskan keinginan untuk menggaruk. Sensasi tersebut disebabkan oleh berbagai hal, misalnya penyakit kulit, penyakit sistemik, atau idiopatik, gangguan psikiatri, serta penyakit neurologis. Pruritus menjadi masalah kesehatan karena dapat memberi dampak negatif terhadap kualitas hidup pasien. Pendekatan tata laksana pruritus diberikan secara bertingkat mulai dari terapi dasar, terapi target, dan terapi simtomatik. Pada kasus pruritus kronik yang refrakter maupun pruritus tanpa sebab yang diketahui, terapi simtomatik berperan besar dan dapat diberikan pada pasien tersebut. Tata laksana pada pruritus kronik saat ini banyak diteliti seiring dengan ditemukan berbagai mekanisme yang mendasari terjadinya pruritus. Sesuai dengan patofisiologi dari pruritus, terapi sistemik yang dikembangkan menargetkan pada reseptor spesifik di sistem saraf dan sistem imunitas yang berperan pada jalur sinyal pruritus. Berbagai terapi terbaru yang masih ditelit...
Journal of Pakistan Association of Dermatology, 2020
Increased life expectancy must be in line with good health and independence at the end of life. E... more Increased life expectancy must be in line with good health and independence at the end of life. Elderly is a state when numerous factors change, including molecular, cellular, physiological, immunological, and psychosocial factors, directly causing functional impairment, inability to adapt and accumulation of various organ failures. As age advances, the immune system undergoes characteristic changes, usually resulting in decreased immune competence, termed immunosenescence. The alterations that happen in immunosenescence, including the abnormal elevation, decrease, and dysregulations of innate and adaptive immune responses, lead to more severe consequences of bacterial and viral infections, also autoimmune diseases and cancer in elderly
Hot and humid countries such as Indonesia have a higher prevalence of acne vulgaris (AV). The act... more Hot and humid countries such as Indonesia have a higher prevalence of acne vulgaris (AV). The activity of skin microbes, not only Cutibacterium acnes, contribute to the formation of AV. Topical and oral antibiotics are routinely prescribed to treat AV. As antimicrobial resistance rates increase globally, there are concerns about decreased efficacy. This study intends to systematically evaluate the microbiomes isolated from AV lesions and their antibiotics susceptibility in Indonesia. The data were retrieved through PubMed, EMBASE, Google Scholar, and ScienceDirect searches for articles published until July 2022 using three multiword searches. Sixteen studies published between 2001 and 2022 were identified from which the data were pooled using a random effects model. The pooled prevalence estimates demonstrated that C. acnes, Staphylococcus epidermidis, and Staphylococcus aureus were the three common microbes associated with AV in Indonesia. Tetracyclines had lower resistance rates c...
: Stem cells are known for their extraordinary properties, mainly their potency, self-renewal, an... more : Stem cells are known for their extraordinary properties, mainly their potency, self-renewal, and clonality. In recent years, we have witnessed notable advancements in the field of cell therapy. Due to its remarkable properties and versatility, this cutting-edge therapy has now become a potentially promising cure for many diseases. Stem cell-based therapies have been utilized to treat various dermatological conditions, for instance, autoimmune skin disorders, atopic dermatitis, skin aging, wound healing, scar treatment, and many others. This article aims to serve as an overview of the current application of cell-based therapy in the field of dermatology.
Open Access Macedonian Journal of Medical Sciences
BACKGROUND: Dermatological emergency is a condition requiring immediate identification and treatm... more BACKGROUND: Dermatological emergency is a condition requiring immediate identification and treatment to reduce mortality and morbidity. There are several dermatoses resulting in emergency room (ER) visits frequently demonstrated by the geriatric population. However, there is a lack of data about elderly with dermatological presentation seen at the ER in Indonesia. AIM: This retrospective study aims to identify the prevalence of dermatological emergency cases in the elderly at three national referral hospitals in Indonesia within 3 years. METHODS: The sample was geriatric patients who came and/or were consulted by the ER to dermatology and venereology (DV) department. The data (e.g., age, sex, history taking, physical findings, and diagnoses) were collected from medical record from each hospital and presented as a descriptive data. RESULTS: This study showed that there were only 37% of all geriatric emergency dermatological consultations from 2017 to 2020. CONCLUSION: This study conc...
Diabetes melitus tipe 2 (DMT2) merupakan penyakit metabolik yang disebabkan oleh peningkatan resi... more Diabetes melitus tipe 2 (DMT2) merupakan penyakit metabolik yang disebabkan oleh peningkatan resistensi insulin, penurunan produksi insulin, atau kombinasi keduanya yang ditandai dengan hiperglikemia. Kelainan kulit kering termasuk salah satu manifestasi DMT2 dengan prevalensi tertinggi, yaitu 69%. Kondisi kulit kering, terutama pada kaki, berpotensi menjadi derajat yang lebih berat dan dapat berkembang menjadi ulkus kaki diabetes. Penanganan dini diperlukan untuk mencegah terjadinya penyulit dan peningkatan morbiditas pada penyandang DM. Kelainan kulit kering berkorelasi erat dengan pengontrolan glikemik yang buruk. Pada kondisi hiperglikemia dapat terjadi berbagai gangguan homeostasis kulit. Selain itu, faktor yang berkontribusi pada kelainan kulit kering adalah akumulasi advanced glycation end product (AGEs), kerusakan vaskular yang progresif, faktor neural, dan sistem imun. Etiopatogenesis kulit kering pada DMT2 meliputi berbagai hal, yaitu mekanisme terjadinya kulit kering seca...
Background: The effectiveness of Isotretinoin is superior compared to other acne therapies, parti... more Background: The effectiveness of Isotretinoin is superior compared to other acne therapies, particularly in reducing acne lesion counts. Concerns, however, arise relating the most optimal dosage regimen with the best efficacy and lesser side effect Objective: We intend to review existing randomized controlled comparative studies of isotretinoin in different regimens Methods: PubMed, Cochrane, Scopus, and ScienceDirect were searched. The inclusion criteria is RCT article. Full-text reading excluded articles that did not use GAGS as the method of measurement. The Out of 921 articles electronically searched, 6 RCTs were extracted and summarized descriptively. After full-text reading, 4 RCTs were included. We then conducted risk of bias assessments for the selected studies using The Cochrane Risk of Bias Tool. Results: Across all trials, low-dose regimens were preferable in all types of acne—owing to its similar efficacy to conventional dose but with fewer occurrence of side effects as ...
Photoaging can significantly contribute to lower quality of life. Medium-deep peeling using trich... more Photoaging can significantly contribute to lower quality of life. Medium-deep peeling using trichloroacetic acid allows controlled keratocoagulation through the dermis and into the dermal papillary layer that is effective for skin rejuvenation. The purpose of this article is to give updates regarding the efficacy, possible adverse events, and patient satisfaction of trichloroacetic acid (TCA) peeling for skin rejuvenation by assessing various photoaging parameters. A systematic review of prospective trial articles collected from PubMed, MEDLINE, EMBASE, Cochrane, and Scopus databases was conducted on November 2, 2020. Treatment efficacy was assessed based on the photoaging parameters used by each study. Adverse events and patient satisfaction as the secondary outcome were assessed based on patients-perceived improvements. Five studies included three randomized comparison studies and two prospective cohort studies. These studies show that TCA peeling significantly improve the cosmesi...
Pruritus merupakan sensasi tidak nyaman yang mencetuskan keinginan untuk menggaruk. Sensasi terse... more Pruritus merupakan sensasi tidak nyaman yang mencetuskan keinginan untuk menggaruk. Sensasi tersebut disebabkan oleh berbagai hal, misalnya penyakit kulit, penyakit sistemik, atau idiopatik, gangguan psikiatri, serta penyakit neurologis. Pruritus menjadi masalah kesehatan karena dapat memberi dampak negatif terhadap kualitas hidup pasien. Pendekatan tata laksana pruritus diberikan secara bertingkat mulai dari terapi dasar, terapi target, dan terapi simtomatik. Pada kasus pruritus kronik yang refrakter maupun pruritus tanpa sebab yang diketahui, terapi simtomatik berperan besar dan dapat diberikan pada pasien tersebut. Tata laksana pada pruritus kronik saat ini banyak diteliti seiring dengan ditemukan berbagai mekanisme yang mendasari terjadinya pruritus. Sesuai dengan patofisiologi dari pruritus, terapi sistemik yang dikembangkan menargetkan pada reseptor spesifik di sistem saraf dan sistem imunitas yang berperan pada jalur sinyal pruritus. Berbagai terapi terbaru yang masih ditelit...
Journal of Pakistan Association of Dermatology, 2020
Increased life expectancy must be in line with good health and independence at the end of life. E... more Increased life expectancy must be in line with good health and independence at the end of life. Elderly is a state when numerous factors change, including molecular, cellular, physiological, immunological, and psychosocial factors, directly causing functional impairment, inability to adapt and accumulation of various organ failures. As age advances, the immune system undergoes characteristic changes, usually resulting in decreased immune competence, termed immunosenescence. The alterations that happen in immunosenescence, including the abnormal elevation, decrease, and dysregulations of innate and adaptive immune responses, lead to more severe consequences of bacterial and viral infections, also autoimmune diseases and cancer in elderly
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