Papers by Marcelo Filgueiras
Lasers in Medical Science
Photobiomodulation therapy (PBMT) is a non-thermal therapeutic procedure widely used in clinical ... more Photobiomodulation therapy (PBMT) is a non-thermal therapeutic procedure widely used in clinical practice. It is considered an effective modality of treatment for the control of various inflammatory conditions with fewer adverse effects as compared to conventional therapy. However, despite the clinical effects, the mechanisms of action and dosimetric parameters of PBMT are not fully understood. This study was performed to describe the effects of two different doses of PBMT on experimental models of inflammation. Male Swiss mice were administered with 0.9% of saline or phlogistic agents (carrageenan, dextran, serotonin, histamine, or bradykinin) by intra-plantar injection and were treated with PBMT at a dose of 1 or 5 J/cm2; right after, the variation of the paw volume was made, and histopathological analysis and myeloperoxidase assay of the carrageenan-induced edematous paw tissues were performed. The action of PBMT on carrageenan-induced vascular permeability was further evaluated. Our results showed that PBMT (1 J/cm2) led to an improvement in paw edema induced by the phlogistic agents and further reduced the histological scores. Inhibition of neutrophil migration was observed following the administration of 1 and 5 J/cm2 of PBMT. However, only 1 J/cm2 of PBMT showed beneficial effects on carrageenan-induced edema. Laser at a dose of 1 J/cm2 showed cellular and vascular effects since it was able to reverse all the inflammatory parameters, and laser at a dose of 5 J/cm2 probably has only cellular effects in the presence of acute inflammation.
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Physical Therapy
Objective Although some studies have shown the clinical benefits of therapeutic exercise in chron... more Objective Although some studies have shown the clinical benefits of therapeutic exercise in chronic nonspecific low back pain, the effect sizes are generally small to moderate and recurrence rates are high. Transcranial direct current stimulation (tDCS) has been used to modulate pain-processing systems and motor outputs and has the potential to optimize the clinical benefits of therapeutic exercise. However, evidence for this combination is still lacking. The purpose of this protocol for a randomized clinical trial is to investigate whether the combination of tDCS and therapeutic exercise is more effective in relieving pain than therapeutic exercise alone. Methods This 2-arm, randomized controlled clinical trial will take place at the Federal University of Piauí, Brazil. Sixty patients will be randomized into 2 groups to receive tDCS (real/sham) + exercise therapies for 12 sessions over a period of 4 weeks. Pain intensity, sensory and affective aspects of pain, physical functioning,...
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Objective: To evaluate the performance of the Family Health Support Center (NASF) through the kno... more Objective: To evaluate the performance of the Family Health Support Center (NASF) through the knowledge and evaluation of services by professionals of the Family Health Strategy (FHS). Methods: Quantitative descriptive study conducted in 2012 with 10 FHS linked to NASF, District 1, Parnaiba - PI - Brazil, where 76 professionals were interviewed using a questionnaire on the characterization of the professional, their knowledge regarding the NASF activities and the evaluation of services provided by the NASF team. The data were divided into categories, grouped and analyzed using SPSS 19.0. Results: In the evaluation of the NASF performance by the members of the FHS, 42% (n=32) considered the service very important, 59.0% (n= 5) of the members were satisfied, 54.0% (n=41) rated the service as accessible to the population, and 90% (n=68) of interviewees recognized which professionals make up the NASF team, highlighting the physiotherapist and the physical educator. Conclusion: It is con...
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Introduction: The Health Family Program (HFP) was raised in the 90´s, following the Brazilian Hea... more Introduction: The Health Family Program (HFP) was raised in the 90´s, following the Brazilian Health System, aiming to increase the population health. This qualitative study was developed in Maracanau city in the Health Family Basic Units (HFBU) with a group of patients with different diseases and different ages. Objective: The objective was to describe the perception of the users about Physical Therapy performance at the health family team. Materials and Methods: Descriptive qualitative study performed at Maracanau city in the metropolitan region of Fortaleza - Ceara, with families assisted by the Health Family Program. 15 subjects were interviewed, 07 caregivers and 08 patients in the period from March to May 2008. Data were collected through unstructured interviews and analyzed through the technique of content analysis. Results: As results the analyzes of the interviews showed three thematic categories: Physical Therapy´s benefits, The access to Physical Therapy, and The interven...
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Resumo: A saude e um fator essencial para o desenvolvimento humano e um dos campos de acao propos... more Resumo: A saude e um fator essencial para o desenvolvimento humano e um dos campos de acao propostos no contexto da promocao da saude e a criacao de ambientes favoraveis. A Organizacao Mundial de Saude (OMS), desde o ano de 2002, desenvolve uma politica de saude que preconiza o chamado envelhecimento ativo. A Fisioterapia , cujo objetivo de estudo e principalmente o movimento humano, colabora lancando mao de seus conhecimentos e recursos fisioterapeuticos com intuito de facilitar a compreensao dos fatores que possam acarretar em diminuicao de qualidade de vida e bem estar nos idosos. A pesquisa teve como objetivo geral descrever a percepcao dos idosos sobre a atuacao da fisioterapia em um programa de promocao da saude. A metodologia utilizada foi descritiva qualitativa na qual foram entrevistados 16 idosos que participam de um Programa de Assistencia Fisioterapeutica dedicada a Terceira Idade no NAMI. Foram incluidos na pesquisa idosos que participavam regularmente do programa e exc...
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Introduction: Lower back pain (LBP), one of the main causes of pain, employee absenteeism and dis... more Introduction: Lower back pain (LBP), one of the main causes of pain, employee absenteeism and disabilities, exhibits a multifactorial and degenerative etiology, with different characteristics. Objective: a) analyze the acute effect of osteopathic treatment on the temperature of three dermatomes of patients with chronic lumbago; and b) assess the subjective pain perception of patients before and after an osteopathic session. Materials and methods: Quasi-experimental cross-sectional study of 14 individuals treated at a physical therapy clinic in Brasilia, Brazil. Data collection included physical therapy, pain scale (VAS), thermographic and anthropometric assessment. Treatment consisted of a single osteopathic session. Results and conclusions: leg and foot temperature declined (∆% = 2.91 and 4.76%, respectively, p = 0005) in the innervations of 2 regions of interest (ROIs) of the L4 lower limb dermatome and pain levels decreased (∆% = 65.98 and 59.92%, p = 0.005) in the men and women,...
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Critical Reviews in Physical and Rehabilitation Medicine
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Carbohydrate polymers, 2018
Polysaccharides extracted from plants are very promising molecules in the field of pharmacotherap... more Polysaccharides extracted from plants are very promising molecules in the field of pharmacotherapy. Knowing this, the aim of this study was to extract, characterize and evaluate the action of the polysaccharide of Morinda citrifolia Linn (Noni-PLS) in biological models of inflammatory processes. The characterization tests shown that sample refers to a heteropolysaccharide composed mainly of homogalacturonan and rhamnogalacturonan. This polysaccharide at dose of 10 mg/kg, when tested in our models of inflammation, showed significant activity in reducing carrageenan-induced paw oedema as well as all mediators edemas. This polysaccharide was able to inhibit the migration of leukocytes to the site of inflammation, and still reduced inflammatory nociception tests. This results, allows us to conclude that the polysaccharide extracted from Morinda citrifolia linn has anti-inflammatory potential since it reversed inflammatory parameters such as edema, leukocyte migration and nociception.
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Lasers in medical science, Jan 28, 2018
The purpose of the study is to investigate the effects of two doses of photobiomodulation (PBM) o... more The purpose of the study is to investigate the effects of two doses of photobiomodulation (PBM) on inflammatory parameters including cell migration and oxidative stress in carrageenan-induced peritonitis models. Twenty-eight mice were divided into four groups: saline; untreated carrageenan (Cg; inflammation induced); and PMB treatment groups L1 and L5 (inflammation induced with carrageenan followed by laser irradiation at 1 and 5 J/cm, respectively). After 30 min of inducing inflammation, laser irradiation was administered every hour, for 4 h. Peritoneal fluid was collected for analyses. The total leukocyte number in the peritoneal fluid in L1 (4.33 ± 2.34) and L5 (4.95 ± 2.86) after PBM was lower than that in Cg (10.93 ± 5.15 cells/ml). The average differential count of neutrophils in the Cg was 9.46 ± 4.31 cells/ml, which was higher than that in L1 (3.7 ± 2.08) and L5 (4.94 ± 2.57). Myeloperoxidase activity was also lower in L1 (1.89 ± 0.43) and L5 (4.84 ± 2.62) than in Cg (22.92 ...
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Nitric Oxide
Hydrogen sulphide (H2S) is a gasotransmitter that participates in various physiological and patho... more Hydrogen sulphide (H2S) is a gasotransmitter that participates in various physiological and pathophysiological processes within the gastrointestinal tract. We studied the effects and possible mechanism of action of H2S in secretory diarrhoea caused by cholera toxin (CT). The possible mechanisms of action of H2S were investigated using an intestinal fluid secretion model in isolated intestinal loops on anaesthetized mice treated with CT. NaHS and Lawesson's reagent and l-cysteine showed antisecretory activity through reduction of intestinal fluid secretion and loss of Cl(-) induced by CT. Pretreatment with an inhibitor of cystathionine-γ-lyase (CSE), dl-propargylglycine (PAG), reversed the effect of l-cysteine and caused severe intestinal secretion. Co-treatment with PAG and a submaximal dose of CT increased intestinal fluid secretion, thus supporting the role of H2S in the pathophysiology of cholera. CT increased the expression of CSE and the production of H2S. Pretreatment with PAG did not reverse the effect of SQ 22536 (an AC inhibitor), bupivacaine (inhibitor of cAMP production), KT-5720 (a PKA inhibitor), and AICAR (an AMPK activator). The treatment with Forskolin does not reverse the effects of the H2S donors. Co-treatment with either NaHS or Lawesson's reagent and dorsomorphin (an AMPK inhibitor) did not reverse the effect of the H2S donors. H2S has antisecretory activity and is an essential molecule for protection against the intestinal secretion induced by CT. Thus, H2S donor drugs are promising candidates for cholera therapy. However, more studies are needed to elucidate the possible mechanism of action.
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Materials science & engineering. C, Materials for biological applications, 2017
Collagen is considered the most abundant protein in the animal kingdom, comprising 30% of the tot... more Collagen is considered the most abundant protein in the animal kingdom, comprising 30% of the total amount of proteins and 6% of the human body by weight. Studies that examine the interaction between silver nanoparticles and proteins have been highlighted in the literature in order to understand the stability of the nanoparticle system, the effects observed in biological systems, and the appearance of new chemical pharmaceutical products. The objective of this study was to analyze the behavior of silver nanoparticles stabilized with collagen (AgNPcol) and to check the skin permeation capacity and action in paw edema induced by carrageenan. AgNPcol synthesis was carried out using solutions of reducing agent sodium borohydride (NaBH4), silver nitrate (AgNO3) and collagen. Characterization was done by using dynamic light scattering (DLS) and X-ray diffraction (XRD) and AFM. Cellular viability testing was performed by using flow cytometry in human melanoma cancer (MV3) and murine fibrob...
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International Archives of Medicine, 2016
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Ciência & Saúde, 2012
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International Archives of Medicine, 2016
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Fisioter Pesqui, Sep 1, 2009
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ABSTRACT
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Fisioterapia e Pesquisa, 2008
As doenças osteomusculares relacionadas ao trabalho (DORT) são distúrbios do aparelho locomotor d... more As doenças osteomusculares relacionadas ao trabalho (DORT) são distúrbios do aparelho locomotor de etiologia ligada à atividade laboral que vêm apresentando incidência crescente em todo o mundo. Este estudo teve o objetivo de descrever a forma como servidores municipais de Fortaleza, CE, vivenciam as DORT. O estudo qualitativo foi realizado em uma clínica de fisioterapia em 2004. Os informantes foram nove servidores (com idades entre 40 e 57 anos) em atendimento fisioterápico na clínica - agentes administrativos, professores e um técnico. Os dados foram coletados por meio da observação participante e de entrevista semi-estruturada. Da análise emergiram as categorias temáticas…
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Fisioterapia e Pesquisa, 2009
Um novo modelo de saúde pública, visando corrigir o sistema de saúde inadequado às necessidades d... more Um novo modelo de saúde pública, visando corrigir o sistema de saúde inadequado às necessidades da população, foi proposto na 8ª Conferência Nacional de Saúde em 1986. Até hoje, porém, o funcionamento do sistema único de saúde (SUS) ainda está muito distante de seus princípios básicos. Uma questão freqüente a respeito é a da capacitação de profissionais para atuar no SUS. Este estudo objetivou avaliar o conhecimento sobre o SUS dos graduandos em Fisioterapia na Universidade de Fortaleza, por meio da aplicação de um questionário especialmente elaborado. Participaram 56 dentre os 68 graduandos em 2007, independente de sexo e idade. Os resultados mostram que 41 (73,2%) dos entrevistados alegam ter recebido na graduação formação adequada para atuar no SUS; 32 (62,5%) tinham feito estágio em unidade básica de saúde; e 47 (83,9%) julgaram-se aptos a atuar no sistema. A média de acertos sobre os princípios doutrinários e organizacionais, origem, função e financiamento do SUS foi significat...
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Papers by Marcelo Filgueiras