Papers by Patrick Anderson
axons into perineuronal central white matter: time course and molecular characterization. J. Comp... more axons into perineuronal central white matter: time course and molecular characterization. J. Comp. Neurol. 518:5; 699–721. In the above-referenced article, author Abirami Pararajasingham should have been listed as Abirami Pararajasingam. This erratum corrects the spelling. VC 2012 Wiley Periodicals, Inc. DOI 10.1002/cne.23113
Restorative Neurology and Neuroscience, 2008
The articles in this special edition illustrate the recent progress in research into regenerative... more The articles in this special edition illustrate the recent progress in research into regenerative approaches to spinal cord injury. The great breakthroughs in our understanding of axonal regeneration in the spinal cord date back to the nerve grafting experiments of Aguayo, Richardson and colleagues (Richardson et al., 1980), which showed that some intrinsic CNS neurons in adult mammals could regenerate axons when provided with a suitable environment, and the studies of Schwab, Caroni and colleagues, who showed that powerful inhibitory molecules were present in CNS myelin and that the effects of such molecules could be blocked by antibodies (Caroni & Schwab, 1988). Subsequently it became apparent that not all intrinsic CNS neurons can regenerate their axons into nerve grafts (Anderson et al., 1998) and that there are many inhibitors of axonal regeneration in the adult mammalian CNS (Bolsover et al., 2008; Giger et al., 2008). However, the importance of these steps in our understandin...
Journal of Neurocytology, 1981
The uptake and retrograde transport of horseradish peroxidase (HRP) and horseradish peroxidase-po... more The uptake and retrograde transport of horseradish peroxidase (HRP) and horseradish peroxidase-poly-L-lysine conjugate (HRP-PL) were compared using a system comprising the guinea-pig inferior mesenteric ganglion (IMG) and ligated hypogastric hypogastric nerves maintained in vitro in a twin chamber apparatus. 0.5 mg of HRP-PL applied to the ligated nerves produced stronger retrograde labelling of neurons within the IMG than did 10 mg of HRP. This may have been due to the greater uptake of HRP-PL in a vesicular form by the axons immediately proximal to the ligation. The possible roles of large rounded vesicles and elongated cisternae in retrograde axoplasmic transport are discussed.
BMC Neuroscience, Jan 24, 2006
<b>Copyright information:</b>Taken from "Efficient delivery of Cre-recombinase t... more <b>Copyright information:</b>Taken from "Efficient delivery of Cre-recombinase to neurons in vivo and stable transduction of neurons using adeno-associated and lentiviral vectors"BMC Neuroscience 2004;5():4-4.Published online 30 Jan 2004PMCID:PMC343275.Copyright © 2004 Ahmed et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. β-galactosidase activity is apparent in and around the needle track in the neocortex (arrows in A and D), in parts of the CA1, CA2 and terminal portion of the CA3 region of the hippocampus and in the dentate gyrus. Cells in stratum lacunosum-moleculare (arrowheads in A and D), corpus callosum (arrow in B and E) were also observed. Parts of CA1 and CA2 from Fig. and are enlarged in Fig. and and the region of the dentate gyrus from Fig. and is enlarged in Fig. and . Scale bars in A = 200 μm (applies also to D); B = 100 μm (applies also to C, E and F).
<b>Copyright information:</b>Taken from "Efficient delivery of Cre-recombinase t... more <b>Copyright information:</b>Taken from "Efficient delivery of Cre-recombinase to neurons in vivo and stable transduction of neurons using adeno-associated and lentiviral vectors"BMC Neuroscience 2004;5():4-4.Published online 30 Jan 2004PMCID:PMC343275.Copyright © 2004 Ahmed et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. LV-Cre-EGFP virus (A-B) and AAV-Cre/AAV-GFP mixture viruses (C-D) were injected into the hippocampus and neocortex of Rosa26 mice 4 weeks before perfusion. The patterns of expression of the two transgenes are almost identical (allowing for the slightly stronger staining obtained with the tyramide-enhanced Cre immunohistochemistry) irrespective of the vector used. Fig. , and show the extent of colocalization of GFP and Cre in the dentate gyrus of an AAV-Cre/AAV-GFP mixture injected Rosa26 mouse brain. In the original micrographs, more cells were Cre positive: 373 cells were Cre positive and 256 cells were GFP positive. However the few green cells in 3G show that some cells expressed GFP alone. The arrowheads and arrows in A-D indicate immunofluorescence in pyramidal cells of CA1 and CA2 respectively. Scale bars, A-D = 200 μm, E-G = 400 μm.
<b>Copyright information:</b>Taken from "Efficient delivery of Cre-recombinase t... more <b>Copyright information:</b>Taken from "Efficient delivery of Cre-recombinase to neurons in vivo and stable transduction of neurons using adeno-associated and lentiviral vectors"BMC Neuroscience 2004;5():4-4.Published online 30 Jan 2004PMCID:PMC343275.Copyright © 2004 Ahmed et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. Very strong GFP expression is present in the molecular layer and polymorphic layer (arrows in B and D) of the dentate gyrus. GFP positive cells are present in CA1, CA2 and terminal part of the CA3 region of the hippocampus (A, C). Strong staining was also observed in presumptive glial cells in the subcortical white matter and corpus callosum (arrows in A and C). Fig. and are enlargements of Fig. and . Scale bars, A and C = 200 μm, B and D = 100 μm.
<b>Copyright information:</b>Taken from "Efficient delivery of Cre-recombinase t... more <b>Copyright information:</b>Taken from "Efficient delivery of Cre-recombinase to neurons in vivo and stable transduction of neurons using adeno-associated and lentiviral vectors"BMC Neuroscience 2004;5():4-4.Published online 30 Jan 2004PMCID:PMC343275.Copyright © 2004 Ahmed et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. All the cells which express EGFP also express Cre. (C, D) Immunohistochemistry for Cre, in HEK 293T cells 16 hrs after exposure to the AAV-Cre virus (1C) and in uninfected HEK 293T cells (1D). Cre is present in the nucleus of large numbers of cells infected with the virus but is absent from uninfected cells. Scale bars A and B = 25 μm, C = 50 μm, D = 100 μm.
European Journal of Neuroscience, Oct 26, 2007
Experimental Neurology, 1999
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Papers by Patrick Anderson