Papers by Matthew Sorenson
Chronic Illness
Objectives Studies have demonstrated immune dysfunction in adolescents with Myalgic Encephalomyel... more Objectives Studies have demonstrated immune dysfunction in adolescents with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS); however, evidence is varied. The current study used network analysis to examine relationships between cytokines among a sample of pediatric participants with ME/CFS. Methods 10,119 youth aged 5–17 in the Chicagoland area were screened for ME/CFS; 111 subjects and controls were brought in for a physician examination and completed a blood draw. Youth were classified as controls (Cs, N = 43), ME/CFS (N = 23) or severe (S-ME/CFS, N = 45). Patterns of plasma cytokine networks were analyzed. Results All participant groups displayed a primary network of interconnected cytokines. In the ME/CFS group, inflammatory cytokines IL-12p70, IL-17A, and IFN-γ were connected and included in the primary membership, suggesting activation of inflammatory mechanisms. The S-ME/CFS group demonstrated a strong relationship between IL-17A and IL-23, a connection associated ...
Bookmarks Related papers MentionsView impact
This publication was made possible by an educational grant from TEVA Neuroscience.
Bookmarks Related papers MentionsView impact
Bookmarks Related papers MentionsView impact
Insights in Biomedicine, 2017
Bookmarks Related papers MentionsView impact
Journal of behavioral and neuroscience research, 2010
Participants with CFS were grouped into viral and non-viral onset fatigue categories and assessed... more Participants with CFS were grouped into viral and non-viral onset fatigue categories and assessed for differential immunological marker expression. Peripheral Blood Mononuclear Cells were assessed for differential phenotypic expression of surface adherence glycoproteins on circulating lymphocytes. The flow cytometric analysis employed fluorescent monoclonal antibody labeling. The viral in comparison to the non-viral group demonstrated significant elevations in several Th1 type subsets including: the percentage and number of CD4+ cells, the percentage and number of CD2+CD26+ cells, the percentage and number of CD2+CD4+CD26+ cells, the percentage and number of CD4+ CD26+ cells, and the percentage of Th2 naïve cells (CD4+ CD45RA+CD62L+). Of the remaining significant findings, the non viral group demonstrated significant elevations in comparison to the viral group for the following Th1 type subsets: the percentage of CD8+ cells, the percentage of T-cytotoxic suppressor cells (CD3+8+), a...
Bookmarks Related papers MentionsView impact
Psychology, 2010
Bookmarks Related papers MentionsView impact
Tropical Medicine and Health, 2008
Bookmarks Related papers MentionsView impact
Cancer Research, 2009
#6019 Background: Literature reports demonstrate that genistein, a soy phytoestrogen, shows a bip... more #6019 Background: Literature reports demonstrate that genistein, a soy phytoestrogen, shows a biphasic response to cell proliferation in breast cancer cells. Genistein increases cell proliferation at low concentrations and decreases cell proliferation at high concentrations. Our previous studies suggest that at low concentrations of genistein the cell proliferative response depends on the type of ER. At high concentrations genistein is believed to act as a tyrosine kinase inhibitor. Currently, the mechanisms of genistein's effect on breast cancer cell proliferation are unclear. The aim of this study was to evaluate the mechanisms of the biphasic response of genistein on breast cancer cell proliferation, specifically by determining the effect of genistein on ER-related cell signaling molecules involved in cell proliferation, cell survival and apoptosis. Based on literature reports, the ER-related cell signaling molecules chosen for this study were ERK1/2, p90RSK, JNK, Akt and NFκ...
Bookmarks Related papers MentionsView impact
Journal of Applied Biobehavioral Research, 2008
Bookmarks Related papers MentionsView impact
Journal Of Chronic Fatigue Syndrome, 2008
Leonard A. Jason, Nadia Reynolds, Molly Brown, Matthew Sorenson, Julie Donalek, and Karina Corrad... more Leonard A. Jason, Nadia Reynolds, Molly Brown, Matthew Sorenson, Julie Donalek, and Karina Corradi are affiliated with De Paul University, Chicago, IL. Susan Torres-Harding is affiliated with Roosevelt University, Chicago, IL. Mary Ann Fletcher is affiliated with University of ...
Bookmarks Related papers MentionsView impact
The purpose of this study was to evaluate predictors of change in physical function in individual... more The purpose of this study was to evaluate predictors of change in physical function in individuals diagnosed with chronic fatigue syndrome (CFS) following participation in nurse delivered, non-pharmacologic interventions. Par-ticipants diagnosed with CFS were randomly assigned to one of four, 6-month interventions including cognitive behavior therapy, cognitive therapy, anaerobic exercise, or a relaxation control group. Baseline measures including immune function, actigraphy, time logs, sleep status, and past psychiatric diagnosis significantly differentiated those participants who demonstrated positive change over time from those who did not. Understanding how patient subgroups differentially respond to non-pharmacologic interventions might provide insights into the pathophysiol-ogy of this illness.
Bookmarks Related papers MentionsView impact
Bookmarks Related papers MentionsView impact
Bookmarks Related papers MentionsView impact
Background: The molecular mechanisms of genistein’s proliferative effects on breast cancer cells ... more Background: The molecular mechanisms of genistein’s proliferative effects on breast cancer cells are largely unknown. This study aimed to examine estrogen-receptor (ER)related signaling molecules involved in genistein-associated cell proliferation and survival (ERK1/2, p90RSK, JNK, Akt and NFκB) and to correlate these results to cell proliferation. Materials and Methods: The effect of genistein on cell-signaling molecules was determined in T47D breast cancer cells by a Bioplex phosphoprotein detection kit. These results were confirmed by Western blotting and were correlated to cell proliferation by MTT assay. Results: Low and high concentrations of genistein induced an ERK1/2-independent decrease in phosphorylated p90RSK. This effect was accompanied by decreased cell proliferation at high concentrations and an increased response at low concentrations of genistein following a 48-hour exposure. Conclusion: Concentration-dependent actions of genistein in T47D cells may be due to differ...
Bookmarks Related papers MentionsView impact
Fatigue: Biomedicine, Health & Behavior
ABSTRACT Background We followed college students before, during, and after infectious mononucleos... more ABSTRACT Background We followed college students before, during, and after infectious mononucleosis (IM) for the development of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Aim We used network analysis to study relationships between pre-illness cytokine data amongst three groups of participants: those 30 who went on to develop ME/CFS following IM (and met one case definition), those 18 who went on to develop severe ME/CFS (S-ME-CFS) following IM (and met greater than one case definition), and those 58 who recovered following IM (controls). Methods We recruited 4501 college students; approximately 5% developed IM during their enrollment at university. Those who developed IM were evaluated at a 6-month follow-up to determine whether they recovered or met criteria for ME/CFS; those who met >1 set of criteria for ME/CFS were termed S-ME/CFS. Patterns of pre-illness cytokine networks were then classified according to the following characteristics: membership, modularity, Eigen centrality, Total centrality, and mean degree. Network statistics were compared across groups using a one-way analysis of variance (ANOVA). Results Those with S-ME/CFS had a more interconnected network of cytokines, whereas recovered controls had more differentiated networks and more subgroupings of cytokine connections. Those with ME/CFS had a network that was denser than the controls, but less dense than those with severe ME/CFS. Conclusions The distinct network differences between these three groups implies that there may be biological differences between our three groups of study participants at baseline.
Bookmarks Related papers MentionsView impact
Advances in Neuroimmune Biology
ABSTRACT
Bookmarks Related papers MentionsView impact
Journal of Nursing Education and Practice
Background: There is evidence linking Lesbian, Gay, Bisexual, and Transgender (LGBT+) health educ... more Background: There is evidence linking Lesbian, Gay, Bisexual, and Transgender (LGBT+) health education with improvement in nursing students’ knowledge, attitudes, and comfort of LGBT+ health considerations.Methods: In a pre- and post-test study design, a total of 77 master’s entry to nursing practice (MENP) students completed the LGBT+ health educational module during the Community Health Nursing course.Results: Statistically significant results were found between pre-test to post-test data for knowledge (p < .001, Cohen’s d 2.52), attitudes (p < .001, Cohen’s d 0.35), and comfort (p = .001, Cohen’s d 0.31) of LGBT+ health considerations.Conclusions: The LGBT+ health education module improved MENP students’ attitudes and comfort with LGBT+ clients and markedly increased their knowledge of LGBT+ health considerations. Findings suggest LGBT+ health education can be implemented by nursing faculty in master’s entry to nursing practice programs with a positive impact on student kno...
Bookmarks Related papers MentionsView impact
Development and Psychopathology
Bookmarks Related papers MentionsView impact
Development and Psychopathology
The ability to regulate stress is a critical developmental milestone of early childhood that invo... more The ability to regulate stress is a critical developmental milestone of early childhood that involves a set of interconnected behavioral and physiological processes and is influenced by genetic and environmental stimuli. Prenatal exposure to traumatic stress and trauma, including intimate partner violence (IPV), increases risk for offspring biobehavioral regulation problems during childhood and adolescence. Although individual differences in susceptibility to prenatal stress have been largely unexplored, a handful of studies suggest children with specific genetic characteristics are most vulnerable to prenatal stress. We evaluated the brain-derived neurotrophic factor Val66Met gene (BDNF) as a moderator of the effect of prenatal IPV exposure on infant temperamental and cortisol regulation in response to a psychosocial challenge. Ninety-nine mother–infant dyads recruited from the community were assessed when infants (51% female) were 11 to 14 months. Maternal reports of IPV during pr...
Bookmarks Related papers MentionsView impact
Fatigue: Biomedicine, Health & Behavior
ABSTRACT Background: Cytokine studies in chronic fatigue syndrome (CFS) have yielded mixed findin... more ABSTRACT Background: Cytokine studies in chronic fatigue syndrome (CFS) have yielded mixed findings. Purpose: This investigation evaluated whether network analysis of cytokine production differs between patients with CFS and multiple sclerosis (MS) as compared to a reference group of healthy controls. Methods: Three subgroups (N = 109) were included: 15 participants who met diagnostic criteria for CFS, 57 participants meeting criteria for MS, and 37 controls. Peripheral blood was obtained and production of a select cytokine profile was determined from stimulated and unstimulated mononuclear cells. Data were generated through the use of a multi-analyte bead suspension array. Pairwise associations were determined for each group, and these associations were used to create a graphical representation of the data. The graph was clustered using an eigenvector community algorithm and results visualized using edges to model the correlations by color and thickness to show direction and strength. Results: The control and MS groups produced a three-neighborhood relationship regardless of cell condition. While producing a three-neighborhood relationship, the MS group differed significantly from the control group as it displayed stronger relationships among pro-inflammatory cytokines. In contrast, the CFS group displayed a three-neighborhood solution when unstimulated. However, when cells from the CFS group were stimulated, a two-neighborhood model was found that exhibited stronger inter-cytokine correlations. The model found in CFS was significantly different from that found in the control and MS groups. Conclusion: CFS was characterized by a pattern of global immunologic activation using network analysis, fundamentally different from those found for either MS or control groups.
Bookmarks Related papers MentionsView impact
Uploads
Papers by Matthew Sorenson