This study is performed beneath In Vitro dissolution applying various mathematical approaches to ... more This study is performed beneath In Vitro dissolution applying various mathematical approaches to observe the dissolution interference on simulated gastrointestinal digestion. In total, eight medicine samples were collected in Bangladeshi market and the conventional approaches were followed to measure the result in gastric medium (pH 1.2). Altogether, the brands showed sensibly upper dissolution discharge; primarily P01 (98.9%), P08 (98.97%), P03 (98.32%) and P06 (98.24%) were released relatively faster than the other sample in 15 to 60 minutes. Along with the mango juice in the simulated gastric medium, the brands showed sensibly upper dissolution discharge; primarily P01 (98.83%), P07 (98.98%), P06 (98.78%) and P03 (98.38%) were released relatively faster than the other sample in 15 to 60 minutes. This result depicts to understand the proper release of kinetics with the help of various mathematical model such as Zero order, First order, Higuchi and Hixson-Crowell model etc. although Paracetamol can interact with the fruit juices, which may alter the drug release, drug absorption in the body and may also lead to an unwanted reaction.
""Background: In the current study, different plant extracts of Gynocardia odorata such as methan... more ""Background: In the current study, different plant extracts of Gynocardia odorata such as methanol extract (ME), aqueous soluble fraction (AQSF), chloroform soluble fraction (CSF), carbon tetrachloride soluble fraction (CTCSF), and petroleum ether soluble fraction (PESF) were examined for the analysis of thrombolytic, cytotoxic, and erythrocyte membrane-stabilizing activities.
Methods: A well-explicated method was accomplished for plant extractives investigation. The plant extractives were involved in thrombolytic, cytotoxic, and erythrocyte membrane-stabilizing activity evaluation, on the basis of their ability of clot lysis, cytotoxic potentials, and stabilizing erythrocyte membrane under hypotonic solution and heat-induced conditions. Both thrombolytic and erythrocyte membrane-stabilizing activities were performed by using Swiss albino laboratory mice. In addition, plant cytotoxic activity was performed by using the nauplii of brine shrimp as in vitro model.
Results: The study of G. odorata extracts enumerated basic thrombolytic activity (19.94 ± 0.53% to 10.64 ± 0.46%; p < 0.05), and basic cytotoxic LC50 value (23.09 ± 2.01 μg mL−1 to 1.18 ± 0.14 μg mL−1; p < 0.05) including statistical analysis confidence limit ranges, chi-square value, and regression equation was entailed. The erythrocyte membrane-stabilizing activity under hypotonic solution-induced hemolysis (47.41 ± 0.46% to 18.445 ± 0.095%; p < 0.05) and heat-induced hemolysis (27.95 ± 0.55% to 17.84 ± 0.59%; p < 0.05) was determined. All the statistical calculation was optimized by one-way ANOVA followed by Tukey's post hoc test including Dunnett t tests.
Conclusion: This study indicates that G. odorata could be a natural medication alternative of thrombolytic agents as well as source of potent bioactive compounds.""
Fresh fruits convenient source of natural phenols and antioxidants which are healthy for human. A... more Fresh fruits convenient source of natural phenols and antioxidants which are healthy for human. At present many
marketed fruit juices claims to be salubrious also full of phenols and antioxidants. In this study enlighten on
investigation of phenols and antioxidant. Five mixed fruits juices were collected from Bangladeshi market for
investigation. For the phenolic contents determination modified Folin–Ciocalteu and 1,1-diphenyl-2-picrylhydrazyl
(DPPH) modified method for antioxidant analysis was applied. The value of phenolic content was S1 (43.88±0.51),
S2 (54.29±0.55), S3 (79.97±1.15), S4 (69.97±1.02) and S5 (57.70±0.78) respectively. On basis of the IC50value was
S1 (81.59±1.20), S2 (49.91±0.85), S3 (28.75±0.76), S4 (24.44±0.67) and S5 (61.075±0.95) respectively. This study
signifies the determination of phenolic contents and antioxidants presence in mixed fruit juices with substantial
activeness.
The present study was on Pterospermum semisagittatum investigated for its phenolic content, free ... more The present study was on Pterospermum semisagittatum investigated for its phenolic content, free radical scavenging (DPPH) assay, Antimicrobial and fungal activity. The highest phenolic content was found in the pet ether (PESF) (4.25±0.08 mg) followed by carbon tetrachloride soluble partitionate (CTCSF) (2.70±0.27 mg), chloroform soluble partitionate (CSF) (0.56±0.29 mg), methanolic extract (ME) (2.41±0.14 mg) and aqueous soluble partitionate (AQSF) (1.67±0.06 mg). In free radical scavenging (DPPH) assay, methanolic extract (ME), carbon tetrachloride soluble partitionate (CTCSF), pet ether (PESF), chloroform soluble partitionate (CSF) and aqueous soluble partitionate AQSF respectively, IC50 was 121.50±0.71, 112.50±1.14, 102.50±0.65 and 53.50±2.12. In Anti-microbial and anti-fungal investigation only chloroform soluble partitionate observed the Slight amount of activity. This study profound that Pterospermum semisagittatum has the remarkable presence of phenolic and antioxidant compound on preliminary investigational evaluation.
This study concentrates on dissolution of drug in presence of fruit juice specifically mango ju... more This study concentrates on dissolution of drug in presence of fruit juice specifically mango juice. This work aspires current research to study the dissolution approach pattern of commercial formulation of metronidazole in Bangladesh commercially available eight brands of metronidazole film coated tablets were studied in gastric medium (pH 1.2). All brands got reasonably higher dissolution release mainly M02 (84.79%), M05 (75.86%), M06 (72.53%) and M07 (86.48%) were released relatively faster than other sample in 15 to 50 minutes. Therefore, Mango juice assists to enhance the therapeutic response of metronidazole on set of quick response.
This study is performed beneath In Vitro dissolution applying various mathematical approaches to ... more This study is performed beneath In Vitro dissolution applying various mathematical approaches to observe the dissolution interference on simulated gastrointestinal digestion. In total, eight medicine samples were collected in Bangladeshi market and the conventional approaches were followed to measure the result in gastric medium (pH 1.2). Altogether, the brands showed sensibly upper dissolution discharge; primarily P01 (98.9%), P08 (98.97%), P03 (98.32%) and P06 (98.24%) were released relatively faster than the other sample in 15 to 60 minutes. Along with the mango juice in the simulated gastric medium, the brands showed sensibly upper dissolution discharge; primarily P01 (98.83%), P07 (98.98%), P06 (98.78%) and P03 (98.38%) were released relatively faster than the other sample in 15 to 60 minutes. This result depicts to understand the proper release of kinetics with the help of various mathematical model such as Zero order, First order, Higuchi and Hixson-Crowell model etc. although Paracetamol can interact with the fruit juices, which may alter the drug release, drug absorption in the body and may also lead to an unwanted reaction.
""Background: In the current study, different plant extracts of Gynocardia odorata such as methan... more ""Background: In the current study, different plant extracts of Gynocardia odorata such as methanol extract (ME), aqueous soluble fraction (AQSF), chloroform soluble fraction (CSF), carbon tetrachloride soluble fraction (CTCSF), and petroleum ether soluble fraction (PESF) were examined for the analysis of thrombolytic, cytotoxic, and erythrocyte membrane-stabilizing activities.
Methods: A well-explicated method was accomplished for plant extractives investigation. The plant extractives were involved in thrombolytic, cytotoxic, and erythrocyte membrane-stabilizing activity evaluation, on the basis of their ability of clot lysis, cytotoxic potentials, and stabilizing erythrocyte membrane under hypotonic solution and heat-induced conditions. Both thrombolytic and erythrocyte membrane-stabilizing activities were performed by using Swiss albino laboratory mice. In addition, plant cytotoxic activity was performed by using the nauplii of brine shrimp as in vitro model.
Results: The study of G. odorata extracts enumerated basic thrombolytic activity (19.94 ± 0.53% to 10.64 ± 0.46%; p < 0.05), and basic cytotoxic LC50 value (23.09 ± 2.01 μg mL−1 to 1.18 ± 0.14 μg mL−1; p < 0.05) including statistical analysis confidence limit ranges, chi-square value, and regression equation was entailed. The erythrocyte membrane-stabilizing activity under hypotonic solution-induced hemolysis (47.41 ± 0.46% to 18.445 ± 0.095%; p < 0.05) and heat-induced hemolysis (27.95 ± 0.55% to 17.84 ± 0.59%; p < 0.05) was determined. All the statistical calculation was optimized by one-way ANOVA followed by Tukey's post hoc test including Dunnett t tests.
Conclusion: This study indicates that G. odorata could be a natural medication alternative of thrombolytic agents as well as source of potent bioactive compounds.""
Fresh fruits convenient source of natural phenols and antioxidants which are healthy for human. A... more Fresh fruits convenient source of natural phenols and antioxidants which are healthy for human. At present many
marketed fruit juices claims to be salubrious also full of phenols and antioxidants. In this study enlighten on
investigation of phenols and antioxidant. Five mixed fruits juices were collected from Bangladeshi market for
investigation. For the phenolic contents determination modified Folin–Ciocalteu and 1,1-diphenyl-2-picrylhydrazyl
(DPPH) modified method for antioxidant analysis was applied. The value of phenolic content was S1 (43.88±0.51),
S2 (54.29±0.55), S3 (79.97±1.15), S4 (69.97±1.02) and S5 (57.70±0.78) respectively. On basis of the IC50value was
S1 (81.59±1.20), S2 (49.91±0.85), S3 (28.75±0.76), S4 (24.44±0.67) and S5 (61.075±0.95) respectively. This study
signifies the determination of phenolic contents and antioxidants presence in mixed fruit juices with substantial
activeness.
The present study was on Pterospermum semisagittatum investigated for its phenolic content, free ... more The present study was on Pterospermum semisagittatum investigated for its phenolic content, free radical scavenging (DPPH) assay, Antimicrobial and fungal activity. The highest phenolic content was found in the pet ether (PESF) (4.25±0.08 mg) followed by carbon tetrachloride soluble partitionate (CTCSF) (2.70±0.27 mg), chloroform soluble partitionate (CSF) (0.56±0.29 mg), methanolic extract (ME) (2.41±0.14 mg) and aqueous soluble partitionate (AQSF) (1.67±0.06 mg). In free radical scavenging (DPPH) assay, methanolic extract (ME), carbon tetrachloride soluble partitionate (CTCSF), pet ether (PESF), chloroform soluble partitionate (CSF) and aqueous soluble partitionate AQSF respectively, IC50 was 121.50±0.71, 112.50±1.14, 102.50±0.65 and 53.50±2.12. In Anti-microbial and anti-fungal investigation only chloroform soluble partitionate observed the Slight amount of activity. This study profound that Pterospermum semisagittatum has the remarkable presence of phenolic and antioxidant compound on preliminary investigational evaluation.
This study concentrates on dissolution of drug in presence of fruit juice specifically mango ju... more This study concentrates on dissolution of drug in presence of fruit juice specifically mango juice. This work aspires current research to study the dissolution approach pattern of commercial formulation of metronidazole in Bangladesh commercially available eight brands of metronidazole film coated tablets were studied in gastric medium (pH 1.2). All brands got reasonably higher dissolution release mainly M02 (84.79%), M05 (75.86%), M06 (72.53%) and M07 (86.48%) were released relatively faster than other sample in 15 to 50 minutes. Therefore, Mango juice assists to enhance the therapeutic response of metronidazole on set of quick response.
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Methods: A well-explicated method was accomplished for plant extractives investigation. The plant extractives were involved in thrombolytic, cytotoxic, and erythrocyte membrane-stabilizing activity evaluation, on the basis of their ability of clot lysis, cytotoxic potentials, and stabilizing erythrocyte membrane under hypotonic solution and heat-induced conditions. Both thrombolytic and erythrocyte membrane-stabilizing activities were performed by using Swiss albino laboratory mice. In addition, plant cytotoxic activity was performed by using the nauplii of brine shrimp as in vitro model.
Results: The study of G. odorata extracts enumerated basic thrombolytic activity (19.94 ± 0.53% to 10.64 ± 0.46%; p < 0.05), and basic cytotoxic LC50 value (23.09 ± 2.01 μg mL−1 to 1.18 ± 0.14 μg mL−1; p < 0.05) including statistical analysis confidence limit ranges, chi-square value, and regression equation was entailed. The erythrocyte membrane-stabilizing activity under hypotonic solution-induced hemolysis (47.41 ± 0.46% to 18.445 ± 0.095%; p < 0.05) and heat-induced hemolysis (27.95 ± 0.55% to 17.84 ± 0.59%; p < 0.05) was determined. All the statistical calculation was optimized by one-way ANOVA followed by Tukey's post hoc test including Dunnett t tests.
Conclusion: This study indicates that G. odorata could be a natural medication alternative of thrombolytic agents as well as source of potent bioactive compounds.""
marketed fruit juices claims to be salubrious also full of phenols and antioxidants. In this study enlighten on
investigation of phenols and antioxidant. Five mixed fruits juices were collected from Bangladeshi market for
investigation. For the phenolic contents determination modified Folin–Ciocalteu and 1,1-diphenyl-2-picrylhydrazyl
(DPPH) modified method for antioxidant analysis was applied. The value of phenolic content was S1 (43.88±0.51),
S2 (54.29±0.55), S3 (79.97±1.15), S4 (69.97±1.02) and S5 (57.70±0.78) respectively. On basis of the IC50value was
S1 (81.59±1.20), S2 (49.91±0.85), S3 (28.75±0.76), S4 (24.44±0.67) and S5 (61.075±0.95) respectively. This study
signifies the determination of phenolic contents and antioxidants presence in mixed fruit juices with substantial
activeness.
http://pubs.sciepub.com/ajps/2/2/1/index.html
""
Methods: A well-explicated method was accomplished for plant extractives investigation. The plant extractives were involved in thrombolytic, cytotoxic, and erythrocyte membrane-stabilizing activity evaluation, on the basis of their ability of clot lysis, cytotoxic potentials, and stabilizing erythrocyte membrane under hypotonic solution and heat-induced conditions. Both thrombolytic and erythrocyte membrane-stabilizing activities were performed by using Swiss albino laboratory mice. In addition, plant cytotoxic activity was performed by using the nauplii of brine shrimp as in vitro model.
Results: The study of G. odorata extracts enumerated basic thrombolytic activity (19.94 ± 0.53% to 10.64 ± 0.46%; p < 0.05), and basic cytotoxic LC50 value (23.09 ± 2.01 μg mL−1 to 1.18 ± 0.14 μg mL−1; p < 0.05) including statistical analysis confidence limit ranges, chi-square value, and regression equation was entailed. The erythrocyte membrane-stabilizing activity under hypotonic solution-induced hemolysis (47.41 ± 0.46% to 18.445 ± 0.095%; p < 0.05) and heat-induced hemolysis (27.95 ± 0.55% to 17.84 ± 0.59%; p < 0.05) was determined. All the statistical calculation was optimized by one-way ANOVA followed by Tukey's post hoc test including Dunnett t tests.
Conclusion: This study indicates that G. odorata could be a natural medication alternative of thrombolytic agents as well as source of potent bioactive compounds.""
marketed fruit juices claims to be salubrious also full of phenols and antioxidants. In this study enlighten on
investigation of phenols and antioxidant. Five mixed fruits juices were collected from Bangladeshi market for
investigation. For the phenolic contents determination modified Folin–Ciocalteu and 1,1-diphenyl-2-picrylhydrazyl
(DPPH) modified method for antioxidant analysis was applied. The value of phenolic content was S1 (43.88±0.51),
S2 (54.29±0.55), S3 (79.97±1.15), S4 (69.97±1.02) and S5 (57.70±0.78) respectively. On basis of the IC50value was
S1 (81.59±1.20), S2 (49.91±0.85), S3 (28.75±0.76), S4 (24.44±0.67) and S5 (61.075±0.95) respectively. This study
signifies the determination of phenolic contents and antioxidants presence in mixed fruit juices with substantial
activeness.
http://pubs.sciepub.com/ajps/2/2/1/index.html
""