Dolihil-P-Man:Man8GlcNAc2-PP-dolihol alfa-1,2-manoziltransferaza
| Dolihil-P-Man:Man8GlcNAc2-PP-dolihol alfa-1,2-manoziltransferaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 2.4.1.261 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Dolihil-P-Man:Man8GlcNAc2-PP-dolihol alfa-1,2-manoziltransferaza (EC 2.4.1.261, ALG9, ALG9 alfa1,2 manoziltransferaza, dolihilfosfomanoza-zavisna ALG9 manoziltransferaza, ALG9 manoziltransferaza, Dol-P-Man:Man8GlcNAc2-PP-Dol alfa-1,2-manoziltransferaza) je enzim sa sistematskim imenom dolihil beta-D-manozil fosfat:D-Man-alfa-(1->2)-D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-(D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-(D-Man-alfa-(1->6))-D-Man-alfa-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol 2-alfa-D-manoziltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- dolihil beta-D-manozil fosfat + D-Man-alfa-(1->2)-D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-[D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-[D-Man-alfa-(1->6)]-D-Man-alfa-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol D-Man-alfa-(1->2)-D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-[D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-[D-Man-alfa-(1->2)-D-Man-alfa-(1->6)]-D-Man-alfa-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol + dolihil fosfat
Tokom formiranja N-glikozilnih veza glikoproteina dolazi do uređivanja sklopa rasprostanjenih oligosaharida sa Glc3Man9GlcNAc2 osnovom na lipidnom nosiocu dolihil difosfatu.
Reference
[уреди | уреди извор]- ^ Vleugels, W., Keldermans, L., Jaeken, J., Butters, T.D., Michalski, J.C., Matthijs, G. and Foulquier, F. (2009). „Quality control of glycoproteins bearing truncated glycans in an ALG9-defective (CDG-IL) patient”. Glycobiology. 19: 910—917. PMID 19451548.
- ^ Frank, C.G. & Aebi, M. (2005). „ALG9 mannosyltransferase is involved in two different steps of lipid-linked oligosaccharide biosynthesis”. Glycobiology. 15: 1156—1163. PMID 15987956.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- Dolichyl-P-Man:Man8GlcNAc2-PP-dolichol+alpha-1,2-mannosyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
