Background Laryngopharyngeal reflux (LPR) is caused by the regurgitation of gastric contents abov... more Background Laryngopharyngeal reflux (LPR) is caused by the regurgitation of gastric contents above the upper esophageal sphincter. Diagnostic gold standard tests like multichannel intraluminal impedance (MII) and 24-h dual-probe pH-metry are invasive and expensive which limits their accessibility especially in resource-limited settings. Since pepsin is only produced in the stomach, detecting pepsin in the laryngopharynx would make it a specific marker for reflux. Therefore, in this study, we measured fasting salivary pepsin in patients with symptoms suggestive of LPR. We aimed to confirm the role of fasting salivary pepsin as a non-invasive diagnostic tool of LPR, to detect a cut-off value for it in Egyptian patients and to study predictors of changes in its level. Methods We conducted a prospective case control study at the gastroenterology clinic in Ain Shams University Hospitals. After testing with esophageal pH-metry, 25 symptomatic patients with confirmed LPR and 25 healthy con...
Background Non-alcoholic fatty liver disease remains asymptomatic until advanced disease, when ri... more Background Non-alcoholic fatty liver disease remains asymptomatic until advanced disease, when risk factor modification and available treatment become no longer effective. Studies on hepatic vasculature can be informative about parenchymal injury and disease severity through the study of changes affecting vascular compliance. This study aimed to study portal vein and hepatic artery hemodynamic variation in non-alcoholic fatty liver and to correlate it with disease severity. Results This case control study included 80 participants; those were further divided into four groups; healthy volunteers and non-alcoholic fatty liver disease patients’ grade 1, 2, and 3. We did anthropometric measures, laboratory tests, transient elastography, and Doppler ultrasound for all participants, and then we collected the data and analyzed it using SPSS version 25. Doppler findings showed that peak maximum velocity, peak minimum velocity, mean flow velocity, portal vein pulsatility index of portal vein,...
Egyptian Liver Journal 2018, 8:98–104 Introduction Prognosis of hepatocellular carcinoma (HCC) is... more Egyptian Liver Journal 2018, 8:98–104 Introduction Prognosis of hepatocellular carcinoma (HCC) is an important issue owing to the limited nonsurgical therapeutic interventions. A noninvasive simple marker could add to the formation of the patient’s therapeutic plan. Aim To examine the effectiveness of different platelet, neutrophil, and lymphocyte-based ratios as prognostic markers for HCC recurrence. Patients and methods A total of 62 patients with HCC treated in Ain Shams University hospitals were included in this study and were divided into two groups according to their inclusion criteria for HCC intervention. Platelet-to-lymphocyte ratio (PLR), platelet-neutrophil to lymphocyte ratio (PNLR), and neutrophil-to-lymphocyte ratio (NLR) other ratios were examined as predictors for early recurrence of HCC. Results In group A, PNLR and PLR change showed a significant relation with recurrence after 1 month. Area under the curve (AUC) were 0.87 and 0.957, respectively. PLR at 1 month sho...
Egyptian Liver Journal 2018, 8:132–135 Background Circulating antivinculin antibodies have been u... more Egyptian Liver Journal 2018, 8:132–135 Background Circulating antivinculin antibodies have been used as a marker for irritable bowel syndrome especially the predominant diarrhea (IBS-D) subtype. There is no available data regarding their use as biomarker in diagnosing and follow up the patients of irritable bowel syndrome in the Middle East. We aim to evaluate the use of antivinculin antibodies as a potential diagnostic biomarker in Egyptian patients of IBS-D. Patients and methods This study was carried out over 9-month duration on 90 individuals, divided into two groups: group 1 included 70 patients with IBS-D, group 2 included 20 healthy volunteers as a normal control group. All participants have been subjected to colonoscopic examination, in addition to measurement of serum levels of selected inflammatory markers and antivinculin antibodies. Results The serum level of antivinculin antibodies was significantly higher in IBS-D patients in comparison to the normal control group, Mor...
Background Laryngopharyngeal reflux (LPR) is caused by the regurgitation of gastric contents abov... more Background Laryngopharyngeal reflux (LPR) is caused by the regurgitation of gastric contents above the upper esophageal sphincter. Diagnostic gold standard tests like multichannel intraluminal impedance (MII) and 24-h dual-probe pH-metry are invasive and expensive which limits their accessibility especially in resource-limited settings. Since pepsin is only produced in the stomach, detecting pepsin in the laryngopharynx would make it a specific marker for reflux. Therefore, in this study, we measured fasting salivary pepsin in patients with symptoms suggestive of LPR. We aimed to confirm the role of fasting salivary pepsin as a non-invasive diagnostic tool of LPR, to detect a cut-off value for it in Egyptian patients and to study predictors of changes in its level. Methods We conducted a prospective case control study at the gastroenterology clinic in Ain Shams University Hospitals. After testing with esophageal pH-metry, 25 symptomatic patients with confirmed LPR and 25 healthy con...
Background Non-alcoholic fatty liver disease remains asymptomatic until advanced disease, when ri... more Background Non-alcoholic fatty liver disease remains asymptomatic until advanced disease, when risk factor modification and available treatment become no longer effective. Studies on hepatic vasculature can be informative about parenchymal injury and disease severity through the study of changes affecting vascular compliance. This study aimed to study portal vein and hepatic artery hemodynamic variation in non-alcoholic fatty liver and to correlate it with disease severity. Results This case control study included 80 participants; those were further divided into four groups; healthy volunteers and non-alcoholic fatty liver disease patients’ grade 1, 2, and 3. We did anthropometric measures, laboratory tests, transient elastography, and Doppler ultrasound for all participants, and then we collected the data and analyzed it using SPSS version 25. Doppler findings showed that peak maximum velocity, peak minimum velocity, mean flow velocity, portal vein pulsatility index of portal vein,...
Egyptian Liver Journal 2018, 8:98–104 Introduction Prognosis of hepatocellular carcinoma (HCC) is... more Egyptian Liver Journal 2018, 8:98–104 Introduction Prognosis of hepatocellular carcinoma (HCC) is an important issue owing to the limited nonsurgical therapeutic interventions. A noninvasive simple marker could add to the formation of the patient’s therapeutic plan. Aim To examine the effectiveness of different platelet, neutrophil, and lymphocyte-based ratios as prognostic markers for HCC recurrence. Patients and methods A total of 62 patients with HCC treated in Ain Shams University hospitals were included in this study and were divided into two groups according to their inclusion criteria for HCC intervention. Platelet-to-lymphocyte ratio (PLR), platelet-neutrophil to lymphocyte ratio (PNLR), and neutrophil-to-lymphocyte ratio (NLR) other ratios were examined as predictors for early recurrence of HCC. Results In group A, PNLR and PLR change showed a significant relation with recurrence after 1 month. Area under the curve (AUC) were 0.87 and 0.957, respectively. PLR at 1 month sho...
Egyptian Liver Journal 2018, 8:132–135 Background Circulating antivinculin antibodies have been u... more Egyptian Liver Journal 2018, 8:132–135 Background Circulating antivinculin antibodies have been used as a marker for irritable bowel syndrome especially the predominant diarrhea (IBS-D) subtype. There is no available data regarding their use as biomarker in diagnosing and follow up the patients of irritable bowel syndrome in the Middle East. We aim to evaluate the use of antivinculin antibodies as a potential diagnostic biomarker in Egyptian patients of IBS-D. Patients and methods This study was carried out over 9-month duration on 90 individuals, divided into two groups: group 1 included 70 patients with IBS-D, group 2 included 20 healthy volunteers as a normal control group. All participants have been subjected to colonoscopic examination, in addition to measurement of serum levels of selected inflammatory markers and antivinculin antibodies. Results The serum level of antivinculin antibodies was significantly higher in IBS-D patients in comparison to the normal control group, Mor...
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