Prof. Dr. Caroline Pot is a clinician-scientist specializing in neuroimmunology with a strong expertise in multiple sclerosis (MS). She was trained as a neurologist in Geneva, Switzerland. In parallel to her clinical expertise, she completed her MD thesis at the University of Zurich in Switzerland and performed a research fellowship at Harvard Medical School in Boston, USA. In 2015, she joined the Department of Clinical Neurosciences at the Lausanne University Hospital, was awarded a Swiss National Science Foundation Professorship, and was nominated associate Professor in 2019. Prof. Dr. Caroline Pot, together with her team, focuses her research on establishing the role of lipid metabolism and mucosal immunology in driving MS. They study the role of the cholesterol metabolites and oxysterols and show that in addition to their contributions to basic metabolic processes, oxysterols are linked to inflammatory processes. More specifically, oxysterols produced during experimental autoimmune encephalomyelitis (EAE) are important in recruiting encephalitogenic T lymphocytes and dampening anti-inflammatory immune responses. In addition, they showed that the gut is an important reservoir for immune cells that are recruited in the intestine before migrating to the central nervous system.
Research Keywords & Expertise
Multiple Sclerosis
Neuroimmunology
immunometabolism
Gut-Brain axis
Experimental autoimmun...
Encephalomyelitis
Lipidic pathways
Fingerprints
Multiple Sclerosis
Encephalomyelitis
Experimental autoimmune
Gut-Brain axis
Short Biography
Prof. Dr. Caroline Pot is a clinician-scientist specializing in neuroimmunology with a strong expertise in multiple sclerosis (MS). She was trained as a neurologist in Geneva, Switzerland. In parallel to her clinical expertise, she completed her MD thesis at the University of Zurich in Switzerland and performed a research fellowship at Harvard Medical School in Boston, USA. In 2015, she joined the Department of Clinical Neurosciences at the Lausanne University Hospital, was awarded a Swiss National Science Foundation Professorship, and was nominated associate Professor in 2019. Prof. Dr. Caroline Pot, together with her team, focuses her research on establishing the role of lipid metabolism and mucosal immunology in driving MS. They study the role of the cholesterol metabolites and oxysterols and show that in addition to their contributions to basic metabolic processes, oxysterols are linked to inflammatory processes. More specifically, oxysterols produced during experimental autoimmune encephalomyelitis (EAE) are important in recruiting encephalitogenic T lymphocytes and dampening anti-inflammatory immune responses. In addition, they showed that the gut is an important reservoir for immune cells that are recruited in the intestine before migrating to the central nervous system.
