The microRNA-23b/27b/24 cluster promotes breast cancer lung metastasis by targeting metastasis-suppressive gene prosaposin
MicroRNAs (miRNAs) have been shown to function as key regulators of tumor progression
and metastasis. Recent studies have indicated that the miRNAs comprising the miR-
23b/27b/24 cluster might influence tumor metastasis, although the precise nature of this
regulation remains unclear. Here, expression of the miR-23b/27b/24 cluster is found to
correlate with metastatic potential in mouse and human breast cancer cell lines and is
elevated in metastatic lung lesions in human breast cancer patients. Ectopic expression of …
and metastasis. Recent studies have indicated that the miRNAs comprising the miR-
23b/27b/24 cluster might influence tumor metastasis, although the precise nature of this
regulation remains unclear. Here, expression of the miR-23b/27b/24 cluster is found to
correlate with metastatic potential in mouse and human breast cancer cell lines and is
elevated in metastatic lung lesions in human breast cancer patients. Ectopic expression of …