[HTML][HTML] Genetic variation in PNPLA3 (adiponutrin) confers sensitivity to weight loss–induced decrease in liver fat in humans
K Sevastianova, A Kotronen, A Gastaldelli… - The American journal of …, 2011 - Elsevier
Background: The rs738409 C→ G single nucleotide polymorphism in the patatin-like
phospholipase domain-containing 3 (PNPLA3; adiponutrin) leads to a missense mutation
(I148M), which is associated with increased liver fat but not insulin resistance. The I148M
mutation impedes triglyceride hydrolysis in vitro, and its carriers have an increased risk of
developing severe liver disease. Objective: We explored whether the rs738409 PNPLA3 G
allele influences the ability of weight loss to decrease liver fat or change insulin sensitivity …
phospholipase domain-containing 3 (PNPLA3; adiponutrin) leads to a missense mutation
(I148M), which is associated with increased liver fat but not insulin resistance. The I148M
mutation impedes triglyceride hydrolysis in vitro, and its carriers have an increased risk of
developing severe liver disease. Objective: We explored whether the rs738409 PNPLA3 G
allele influences the ability of weight loss to decrease liver fat or change insulin sensitivity …