Effect of vitamin D3 supplementation and influence of BsmI polymorphism of the VDR gene of the inflammatory profile and oxidative stress in elderly women with …

IG de Medeiros Cavalcante, AS Silva, MJC Costa… - Experimental …, 2015 - Elsevier
Objective This study aimed to evaluate the effect of vitamin D3 megadose supplementation
and influence of BsmI polymorphism in the VDR gene on the inflammatory profile and
oxidative stress in elderly women with vitamin D deficiency. Methods A double blind,
randomized, placebo-controlled trial was conducted with 40 elderly women (aged 68±6
years) diagnosed with vitamin D insufficiency (24.7±3.1 ng/mL). Participants were distributed
into a supplementation group that received 200,000 IU of vitamin D3 (SG; n= 20) and a …