Understanding how out-of-equilibrium states thermalize under quantum unitary dynamics is an important problem in many-body physics. In this work, we propose a statistical ansatz for the matrix elements of non-equilibrium initial states in the energy eigenbasis. The approach is inspired by the Eigenstate Thermalisation Hypothesis (ETH) but the proposed ansatz exhibits different scaling. Importantly, exponentially small cross-correlations between the observable and the initial state matrix elements determine relaxation dynamics toward equilibrium. We numerically verify scaling and cross-correlation, point out the emergent universality of the high-frequency behavior, and outline possible generalizations.