We investigate the implications of the Baryon Acoustic Oscillation measurements released by the Dark Energy Spectroscopic Instrument (DESI) for Interacting Dark Energy (IDE) models characterized by an energy-momentum flow from Dark Matter to Dark Energy. By combining Planck-2018 and DESI data, we observe a preference for interactions exceeding the 95% confidence level, yielding a present-day expansion rate km/s/Mpc, in agreement with SH0ES. This preference remains robust when including measurements of the expansion rate obtained from the relative ages of massive, early-time, and passively-evolving galaxies, as well as when considering distance moduli measurements from Type-Ia Supernovae sourced from the Pantheon-plus catalog using the SH0ES Cepheid host distances as calibrators. Overall, high and low redshift data can be equally or better explained within the IDE framework compared to CDM, while also yielding higher values of in better agreement with the local distance ladder estimate.