If the QCD axion is a significant component of dark matter, and if the Universe was once hotter than a few hundred MeV, the axion relic abundance depends on the function , the temperature-dependent topological susceptibility. Uncertainties in this quantity induce uncertainties in the axion mass as a function of the relic density, or vice versa. At high temperatures, theoretical uncertainties enter through the dilute instanton gas computation, while in the intermediate and strong coupling regime, only lattice QCD can determine precisely. We reassess the uncertainty on the instanton contribution, arguing that it amounts to less than 20% in the effective action, or a factor of 20 in at . We then combine the instanton uncertainty with a range of models for at intermediate temperatures and determine the impact on the axion relic density. We find that for a given relic density and initial misalignment angle, the combined uncertainty amounts to a factor of 2–3 in the zero-temperature axion mass.