The Host Protease TMPRSS2 Plays a Major Role in In Vivo Replication of Emerging H7N9 and Seasonal Influenza Viruses

K Sakai, Y Ami, M Tahara, T Kubota, M Anraku… - Journal of …, 2014 - Am Soc Microbiol
Proteolytic cleavage of the hemagglutinin (HA) protein is essential for influenza A virus (IAV)
to acquire infectivity. This process is mediated by a host cell protease(s) in vivo. The type II …

Cooperative effect of the attenuation determinants derived from poliovirus sabin 1 strain is essential for attenuation of enterovirus 71 in the NOD/SCID mouse infection …

M Arita, Y Ami, T Wakita, H Shimizu - Journal of virology, 2008 - Am Soc Microbiol
Enterovirus 71 (EV71) is a causative agent of hand, foot, and mouth disease and is also
associated with serious neurological disorders. An attenuated EV71 strain [EV71(S1-3′)] has …

Neutralizing-antibody-independent SARS-CoV-2 control correlated with intranasal-vaccine-induced CD8+ T cell responses

…, K Kusano, R Shimazaki, Y Suzaki, Y Ami… - Cell Reports …, 2022 - cell.com
Effective vaccines are essential for the control of the coronavirus disease 2019 (COVID-19)
pandemic. Currently developed vaccines inducing severe acute respiratory syndrome …

LC16m8, a highly attenuated vaccinia virus vaccine lacking expression of the membrane protein B5R, protects monkeys from monkeypox

M Saijo, Y Ami, Y Suzaki, N Nagata, N Iwata… - Journal of …, 2006 - Am Soc Microbiol
The potential threat of smallpox as a bioweapon has led to the production and stockpiling of
smallpox vaccine in some countries. Human monkeypox, a rare but important viral zoonosis …

Temperature-sensitive mutants of enterovirus 71 show attenuation in cynomolgus monkeys

M Arita, H Shimizu, N Nagata, Y Ami… - Journal of general …, 2005 - microbiologyresearch.org
Enterovirus 71 (EV71) is one of the major causative agents of hand, foot and mouth disease
and is sometimes associated with serious neurological disorders. In this study, an attempt …

An attenuated strain of enterovirus 71 belonging to genotype a showed a broad spectrum of antigenicity with attenuated neurovirulence in cynomolgus monkeys

M Arita, N Nagata, N Iwata, Y Ami, Y Suzaki… - Journal of …, 2007 - Am Soc Microbiol
Enterovirus 71 (EV71) is a causative agent of hand, foot, and mouth disease and is also
sometimes associated with serious neurological disorders. In this study, we characterized the …

Lethal canine distemper virus outbreak in cynomolgus monkeys in Japan in 2008

K Sakai, N Nagata, Y Ami, F Seki, Y Suzaki… - Journal of …, 2013 - Am Soc Microbiol
Canine distemper virus (CDV) has recently expanded its host range to nonhuman primates.
A large CDV outbreak occurred in rhesus monkeys at a breeding farm in Guangxi Province, …

Recovery of pathogenic measles virus from cloned cDNA

…, K Takeuchi, N Miyajima, F Kobune, Y Ami… - Journal of …, 2000 - Am Soc Microbiol
Reverse genetics technology so far established for measles virus (MeV) is based on the
Edmonston strain, which was isolated several decades ago, has been passaged in …

Differential localization of neurons susceptible to enterovirus 71 and poliovirus type 1 in the central nervous system of cynomolgus monkeys after intravenous …

N Nagata, T Iwasaki, Y Ami, Y Tano… - Journal of General …, 2004 - microbiologyresearch.org
Poliovirus and enterovirus 71 (EV71) are both neurotropic enteroviruses that cause serious
neurological diseases, such as poliomyelitis and encephalitis. The neurovirulence of EV71 …

Mongolia gerbils are broadly susceptible to hepatitis E virus

W Zhang, Y Ami, Y Suzaki, YH Doan, M Muramatsu… - Viruses, 2022 - mdpi.com
Although cell culture systems for hepatitis E virus (HEV) have been established by using
cell lines such as PLC/PRF/5 and A549, small-animal models for this virus are limited. Since …