Organoboron compounds have important synthetic value and can be applied in numerous
transformations. The development of practical and convenient ways to synthesize boronate …

Hypoxia-inducible factor (HIF) is a transcriptional complex that plays a central role in the
regulation of gene expression by oxygen. In oxygenated and iron replete cells, HIF-α subunits …

Endergonic photocatalysis is the use of light to perform catalytic reactions that are
thermodynamically unfavourable. While photocatalysis has become a powerful tool in facilitating …

HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis.
Recent studies have defined posttranslational modification by prolyl hydroxylation as a key …

Till now, the novel Mg alloys acting as the medical materials have drawn much attention,
due to their spontaneous degradability, favorable mechanical properties and the excellent …

Hypoxia-inducible factor (HIF) is a transcriptional regulator that plays a key role in many aspects
of oxygen homeostasis. The heterodimeric HIF complex is regulated by proteolysis of its …

Mutations in isocitrate dehydrogenases (IDHs) have a gain‐of‐function effect leading to R(−)‐2‐hydroxyglutarate
(R‐2HG) accumulation. By using biochemical, structural and cellular …

Activity of the hypoxia-inducible factor (HIF) complex is controlled by oxygen-dependent
hydroxylation of prolyl and asparaginyl residues. Hydroxylation of specific prolyl residues by 2-…

A key function of blood vessels, to supply oxygen, is impaired in tumors because of abnormalities
in their endothelial lining. PHD proteins serve as oxygen sensors and may regulate …

It is now clear that resident myofibroblasts play a central role in the mediation of tissue
fibrosis. The aim of the work outlined in this study is to increase our understanding of the …