User profiles for Junjie Chen
Junjie ChenHarbin Institute of Technology, Shenzhen Verified email at hit.edu.cn Cited by 2490 |
Association of BRCA1 with Rad51 in mitotic and meiotic cells
R Scully, J Chen, A Plug, Y Xiao, D Weaver… - Cell, 1997 - cell.com
BRCA1 immunostaining reveals discrete, nuclear foci during S phase of the cell cycle. Human
Rad51, a homolog of bacterial RecA, behaves similarly. The two proteins were found to …
Rad51, a homolog of bacterial RecA, behaves similarly. The two proteins were found to …
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly
…, R Grant, I Manke, K Minn, X Yu, MB Yaffe, J Chen - Cell, 2007 - cell.com
DNA-damage signaling utilizes a multitude of posttranslational modifiers as molecular switches
to regulate cell-cycle checkpoints, DNA repair, cellular senescence, and apoptosis. Here …
to regulate cell-cycle checkpoints, DNA repair, cellular senescence, and apoptosis. Here …
Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress
IM Ward, J Chen - Journal of Biological Chemistry, 2001 - ASBMB
… Junjie Chen Junjie Chen … Chen HT …
DBC1 is a negative regulator of SIRT1
JE Kim, J Chen, Z Lou - Nature, 2008 - nature.com
The NAD-dependent protein deacetylase Sir2 (silent information regulator 2) regulates
lifespan in several organisms 1 , 2 , 3 . SIRT1, the mammalian orthologue of yeast Sir2, …
lifespan in several organisms 1 , 2 , 3 . SIRT1, the mammalian orthologue of yeast Sir2, …
[HTML][HTML] Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage
R Scully, J Chen, RL Ochs, K Keegan, M Hoekstra… - Cell, 1997 - cell.com
BRCA1 localizes to discrete nuclear foci (dots) during S phase. Hydroxyurea-mediated DNA
synthesis arrest of S phase MCF7 cells led to a loss of BRCA1 from these structures. …
synthesis arrest of S phase MCF7 cells led to a loss of BRCA1 from these structures. …
The BRCT domain is a phospho-protein binding domain
X Yu, CCS Chini, M He, G Mer, J Chen - Science, 2003 - science.org
The carboxyl-terminal domain (BRCT) of the Breast Cancer Gene 1 (BRCA1) protein is an
evolutionarily conserved module that exists in a large number of proteins from prokaryotes to …
evolutionarily conserved module that exists in a large number of proteins from prokaryotes to …
DNA damage-induced G2–M checkpoint activation by histone H2AX and 53BP1
O Fernandez-Capetillo, HT Chen, A Celeste, I Ward… - Nature cell …, 2002 - nature.com
Activation of the ataxia telangiectasia mutated (ATM) kinase triggers diverse cellular
responses to ionizing radiation (IR), including the initiation of cell cycle checkpoints 1 . Histone …
responses to ionizing radiation (IR), including the initiation of cell cycle checkpoints 1 . Histone …
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals
…, A Nussenzweig, TT Paull, FW Alt, J Chen - Molecular cell, 2006 - cell.com
MDC1 functions in checkpoint activation and DNA repair following DNA damage. To address
the physiological role of MDC1, we disrupted the MDC1 gene in mice. MDC1 −/− mice …
the physiological role of MDC1, we disrupted the MDC1 gene in mice. MDC1 −/− mice …
AMPK modulates Hippo pathway activity to regulate energy homeostasis
The Hippo pathway was discovered as a conserved tumour suppressor pathway restricting
cell proliferation and apoptosis. However, the upstream signals that regulate the Hippo …
cell proliferation and apoptosis. However, the upstream signals that regulate the Hippo …
Haplotype-resolved diverse human genomes and integrated analysis of structural variation
INTRODUCTION The characterization of the full spectrum of genetic variation is critical to
understanding human health and disease. Recent technological advances have made it …
understanding human health and disease. Recent technological advances have made it …