User profiles for Jason Brown
RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
Calcitonin-gene-related peptide (CGRP) and adrenomedullin are related peptides with
distinct pharmacological profiles. Here we show that a receptor with seven transmembrane …
distinct pharmacological profiles. Here we show that a receptor with seven transmembrane …
SDM toolbox: a python‐based GIS toolkit for landscape genetic, biogeographic and species distribution model analyses
JL Brown - Methods in Ecology and Evolution, 2014 - Wiley Online Library
Species distribution models ( SDM s) are broadly used in ecological and evolutionary studies.
Almost all SDM methods require extensive data preparation in a geographic information …
Almost all SDM methods require extensive data preparation in a geographic information …
PD-L1 expression correlates with tumor-infiltrating lymphocytes and response to neoadjuvant chemotherapy in breast cancer
H Wimberly, JR Brown, K Schalper, H Haack… - Cancer immunology …, 2015 - AACR
Programmed death 1 ligand 1 (PD-L1) is an immune regulatory molecule that limits antitumor
immune activity. Targeting of PD-L1 and other immune checkpoint proteins has shown …
immune activity. Targeting of PD-L1 and other immune checkpoint proteins has shown …
Transient expression of doublecortin during adult neurogenesis
JP Brown, S Couillard‐Després… - Journal of …, 2003 - Wiley Online Library
During development of the central nervous system, expression of the microtubule binding
protein doublecortin (DCX) is associated with migration of neuroblasts. In addition to this …
protein doublecortin (DCX) is associated with migration of neuroblasts. In addition to this …
The Novel Anticonvulsant Drug, Gabapentin (Neurontin), Binds to the α2δ Subunit of a Calcium Channel (∗)
NS Gee, JP Brown, VUK Dissanayake, J Offord… - Journal of Biological …, 1996 - ASBMB
Gabapentin (1-(aminomethyl)cyclohexane acetic acid; Neurontin) is a novel anticonvulsant
drug, with a mechanism of action apparently dissimilar to that of other antiepileptic agents. …
drug, with a mechanism of action apparently dissimilar to that of other antiepileptic agents. …
Hypothesis on cerebral dominance
JW Brown, J Jaffe - Neuropsychologia, 1975 - Elsevier
We hypothesize that cerebral dominance is a continuous process which evolves throughout
life and which accounts for the age-dependent forms of aphasia. In addition to progressive (…
life and which accounts for the age-dependent forms of aphasia. In addition to progressive (…
Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis
J Brown, CM Cooper‐Kuhn… - European journal of …, 2003 - Wiley Online Library
Exposure to an enriched environment and physical activity, such as voluntary running, increases
neurogenesis of granule cells in the dentate gyrus of adult mice. These stimuli are also …
neurogenesis of granule cells in the dentate gyrus of adult mice. These stimuli are also …
SDMtoolbox 2.0: the next generation Python-based GIS toolkit for landscape genetic, biogeographic and species distribution model analyses
SDMtoolbox 2.0 is a software package for spatial studies of ecology, evolution, and genetics.
The release of SDMtoolbox 2.0 allows researchers to use the most current ArcGIS software …
The release of SDMtoolbox 2.0 allows researchers to use the most current ArcGIS software …
A summary of mechanistic hypotheses of gabapentin pharmacology
…, NS Gee, TZ Su, JD Kocsis, DF Welty, JP Brown… - Epilepsy research, 1998 - Elsevier
Although the cellular mechanisms of pharmacological actions of gabapentin (Neurontin ® )
remain incompletely described, several hypotheses have been proposed. It is possible that …
remain incompletely described, several hypotheses have been proposed. It is possible that …
How does risk selection respond to risk adjustment? New evidence from the Medicare Advantage Program
J Brown, M Duggan, I Kuziemko… - American Economic …, 2014 - aeaweb.org
To combat adverse selection, governments increasingly base payments to health plans and
providers on enrollees' scores from risk-adjustment formulae. In 2004, Medicare began to …
providers on enrollees' scores from risk-adjustment formulae. In 2004, Medicare began to …