… of Iron in pathophysiologic conditions. Essential to ensure survival, disruption of iron homeostasis
has … anemia and iron-overload related disorders. In particular, the importance of tissue …

… by iron. Furthermore, we discuss recent advances in the understanding of the regulation
of cellular and systemic iron homeostasis and several key diseases resulting from iron …

… Thus, disruption of iron homeostasis may be involved in diseases of the CNS. Iron deficiency
in children can cause auditory defects due to myelin disruption (Roncagliolo et al., 1998). …

… the regulation of pulmonary iron homeostasis, its functional … iron levels and lung diseases.
Gaining greater knowledge on how iron contributes to the pathogenesis of these diseases …

… hemochromatosis protein HFE, the iron importer Nramp2, the iron exporter ferroportin1, and
… their important roles in maintaining body's iron homeostasis. Functional studies of these …

… absence of an excretory system, to remove excess iron. Due to the unique nature of iron
metabolism, iron homeostasis is achieved by integrated specialized mechanisms that operate at …

… are involved in iron homeostasis, such as ferritin and transferrin, have been known for many
decades, much of our understanding of the molecular basis of iron metabolism has come in …

… and physiological aspects of ROS- and iron-mediated signaling. In addition… iron homeostasis
at the cellular and systemic levels, and focus on the pathogenesis and management of iron …

… include the role of iron in pulmonary disease. He is the author of numerous publications,
which focus on the association of human injury and disease with altered iron homeostasis. …

… [2] describe iron homeostasis in detail in their reviews of iron toxicity and the retina. The
following is a summary of relevant aspects of iron homeostasis. Dietary iron is reduced from the …