The synthesis and evaluation of a series of neutral analogues of thioflavin-T (termed BTA's)
with high affinities for aggregated amyloid and a wide range of lipophilicities are reported. …

The synthesis of a new lipophilic thioflavin-T analogue (2-[4′-(methylamino)phenyl]benzothiazole,
6) with high affinity for amyloid is reported. Intravenous injection of [ 11 C]-labeled 6 …

For 100 years, β-amyloid (Aβ) plaques and neurofibrillary tangles (NFTs) have been recognized
as the neuropathological hallmarks of Alzheimer's disease (AD), and their presence or …

This report describes the first human study of a novel amyloid‐imaging positron emission
tomography (PET) tracer, termed Pittsburgh Compound‐B (PIB), in 16 patients with diagnosed …

Objectives Amyloid‐β 42 (Aβ 42 ) appears central to Alzheimer's disease (AD) pathogenesis
and is a major component of amyloid plaques. Mean cerebrospinal fluid (CSF) Aβ 42 is …

In this chapter, we provide a review of the challenges and advances in developing successful
PET imaging agents for 3 major types of aggregated amyloid proteins: amyloid-beta (Aβ), …

Alzheimer's disease (AD) and antecedent factors associated with AD were explored using
amyloid imaging and unbiased measures of longitudinal atrophy in combination with …

During the development of in vivo amyloid imaging agents, an effort was made to use micro-positron
emission tomography (PET) imaging in the presenilin-1 (PS1)/amyloid precursor …

Objective Assess Aβ deposition longitudinally and explore its relationship with cognition and
disease progression. Methods Clinical follow‐up was obtained 20 ± 3 months after [ 11 C]…

Objective To characterize the prevalence of amyloid deposition in a clinically unimpaired
elderly population, as assessed by Pittsburgh Compound B (PiB) positron emission …