Hans H Diebner
Experience in mathematical and biostatistical modelling
Supervisors: Nina Timmesfeld, Ichiro Tsuda, Klaus Dietz, Gerold Baier, and Otto E. Rössler
Address: Ruhr-Universität Bochum
Abteilung für Medizinische Informatik, Biometrie und Epidemiologie
D-44780 Bochum
Supervisors: Nina Timmesfeld, Ichiro Tsuda, Klaus Dietz, Gerold Baier, and Otto E. Rössler
Address: Ruhr-Universität Bochum
Abteilung für Medizinische Informatik, Biometrie und Epidemiologie
D-44780 Bochum
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References:
Hans H. Diebner, Jörg Kirberg, and Ingo Roeder: An evolutionary stability perspective on oncogenesis control in mature T-cell populations. Journal of Theoretical Biology, 389 (21 January), 88-100 (2016).
Kirberg, J., Berns, A., Boehmer, H. J. Exp. Med., 186 (8), 1269, (1997).
Newrzela, S., Al-Ghaili, N., Heinrich, T., Petkova, M., Hartmann, S., Rengstl, B., Kumar, A., Jack, H.-M., Gerdes, S., Roeder, I., Hansmann, M.-L., von Laer, D. Leukemia, 26, 2499 (2012)
Rocha, B., Boehmer, H.v. Science, 251, 1225 (1991).
An analysis known from the studies of evolutionary stability allows for the derivation of a fitness function that relates systems parameters with clonal diversity in order to gain conditions under which the leukemic invaders are suppressed. The model well captures the experimental observation that transgenic clones are outcompeted under a polyclonal condition whereas monoclonality leads to tumour outgrowth. The conditional function allows to investigate the system with respect to other dynamical behaviours as, for example, co-existence of both healthy as well as leukemic clone variants. Since quality and quantity of available sp-MHC complexes appear to vary over the lymphatic system (lymph node dependent niche hierarchies), our model may stimulated further experiments in this direction as, for example, local and temporal niche variations and their impact on clonal diversity.
In his historical and epistemological investigations, Andy Pickering felt compelled to call the constructive approaches of complex systems sciences an „ontological theatre“ [3], thus putting them quasi equal to performative practices in the arts. Yet, in such an equalisation the non-propositional aspects of the arts or, using Martin Heideggers vocabulary, the fundamental ontological basis of the arts, is buried in oblivion [4]. Although Pickering claims that complexity theory escapes from the process of enframing, it rather perfects what Heidegger called machination.
Within the scope of performative science, several „ontological stagings“ have been constructed and presented to the public either in (real) opera stagings (cf. snapshots of the reactive installation “Liquid Perceptron” above) or within the scope of exhibitions and performances [1]. No doubt, such stagings caused reflections about scientific contents but also meta reflections about art and science including their hybridisations, which all to often mock sciences and at the same time ridicule art.
After all, performative science is understood as a critical discourse [5]. From this perspective, the art-science synergy is unlocked neither by a unification of art and science nor by building a bridge, but rather by allowing for leaps down from the enframed sciences into the abyss that is called art.
References:
1. Hans H. Diebner: Performative Science and Beyond. Springer, Wien, 2006.
2. Jens Badura, Selma Dubach, Anke Haarmann, Dieter Mersch, Anton Rey, Christoph Schenker, Germán Toro Pérez (Hrsg.): Künstlerische Forschung. Ein Handbuch. Diaphanes, Zürich, 2015.
3. Andrew Pickering: The mangle of practice time, agency, and science. University of Chicago Press, Chicago, Illinois, 1995.
4. Martin Heidegger: Gesamtausgabe. Klostermann, Frankfurt, 1975-dato.
5. Hans H. Diebner (Hrsg.): Performative Science - Reconciliation of Science and Humanities or the End of Philosophy? Dossier published by Studia UBB. Philosophia LVII, 1/2012.