Abstract
One of the best studied systems for mammalian chromatin remodeling is transcriptional regulation during T cell development. The variety of these studies have led to important findings in T cell gene regulation and cell fate determination. Importantly, these findings have also advanced our knowledge of the function of remodeling enzymes in mammalian gene regulation. First we briefly present biochemical and cell-free analysis of 3 types of ATP dependent remodeling enzymes (SWI/SNF, Mi2, and ISWI) to construct an intellectual framework to understand how these enzymes might be working. Second, we compare and contrast the function of these enzymes during early (thymic) and late (peripheral) T cell development. Finally, we examine some of the gaps in our present understanding.
Publication types
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Research Support, N.I.H., Intramural
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Review
MeSH terms
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Adenosine Triphosphatases / genetics
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Adenosine Triphosphatases / metabolism
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Adenosine Triphosphate / metabolism*
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Animals
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Chromatin / metabolism*
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Chromatin Assembly and Disassembly*
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Chromosomal Proteins, Non-Histone / genetics
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Chromosomal Proteins, Non-Histone / metabolism
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Gene Expression Regulation, Enzymologic
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Humans
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Mi-2 Nucleosome Remodeling and Deacetylase Complex / genetics
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Mi-2 Nucleosome Remodeling and Deacetylase Complex / metabolism
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T-Lymphocytes / cytology
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T-Lymphocytes / enzymology
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T-Lymphocytes / metabolism*
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Transcription Factors / genetics
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Transcription Factors / metabolism
Substances
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Chromatin
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Chromosomal Proteins, Non-Histone
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ISWI protein
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SWI-SNF-B chromatin-remodeling complex
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Transcription Factors
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Adenosine Triphosphate
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Mi-2 Nucleosome Remodeling and Deacetylase Complex
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Adenosine Triphosphatases