Abstract
A new method for the construction of tetrahydropyrans derived from readily available 1,2-dioxines containing a tethered hydroxyl moiety is described. The reaction proceeds via a base-catalyzed rearrangement of the 1,2-dioxines to either the isomeric cis or trans gamma-hydroxy enones followed by intramolecular oxa-Michael addition of the tethered hydroxyl group.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anticholesteremic Agents / chemistry
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Antimitotic Agents / chemistry
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Heterocyclic Compounds, 1-Ring / chemistry*
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Hydroxyl Radical / chemistry*
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Molecular Structure
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Pyrans / chemical synthesis*
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Pyrans / chemistry*
Substances
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Anticholesteremic Agents
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Antimitotic Agents
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Heterocyclic Compounds, 1-Ring
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Pyrans
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Hydroxyl Radical