[go: up one dir, main page]
Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

6,122 results

Filters applied: . Clear all
Results are displayed in a computed author sort order. The Results By Year timeline is not available.
Page 1
Discovery of N-[2-hydroxy-6-(4-methoxybenzamido)phenyl]-4- (4-methyl-1,4-diazepan-1-yl)benzamide (darexaban, YM150) as a potent and orally available factor Xa inhibitor.
Hirayama F, Koshio H, Ishihara T, Hachiya S, Sugasawa K, Koga Y, Seki N, Shiraki R, Shigenaga T, Iwatsuki Y, Moritani Y, Mori K, Kadokura T, Kawasaki T, Matsumoto Y, Sakamoto S, Tsukamoto S. Hirayama F, et al. Among authors: matsumoto y. J Med Chem. 2011 Dec 8;54(23):8051-65. doi: 10.1021/jm200868m. Epub 2011 Nov 11. J Med Chem. 2011. PMID: 21995444
Design, synthesis and biological activity of YM-60828 derivatives: potent and orally-bioavailable factor Xa inhibitors based on naphthoanilide and naphthalensulfonanilide templates.
Hirayama F, Koshio H, Ishihara T, Watanuki S, Hachiya S, Kaizawa H, Kuramochi T, Katayama N, Kurihara H, Taniuchi Y, Sato K, Sakai-Moritani Y, Kaku S, Kawasaki T, Matsumoto Y, Sakamoto S, Tsukamoto S. Hirayama F, et al. Among authors: matsumoto y. Bioorg Med Chem. 2002 Aug;10(8):2597-610. doi: 10.1016/s0968-0896(02)00106-2. Bioorg Med Chem. 2002. PMID: 12057649
Design, synthesis and biological activity of YM-60828 derivatives. Part 2: potent and orally-bioavailable factor Xa inhibitors based on benzothiadiazine-4-one template.
Hirayama F, Koshio H, Katayama N, Ishihara T, Kaizawa H, Taniuchi Y, Sato K, Sakai-Moritani Y, Kaku S, Kurihara H, Kawasaki T, Matsumoto Y, Sakamoto S, Tsukamoto S. Hirayama F, et al. Among authors: matsumoto y. Bioorg Med Chem. 2003 Feb 6;11(3):367-81. doi: 10.1016/s0968-0896(02)00462-5. Bioorg Med Chem. 2003. PMID: 12517432
Orally active factor Xa inhibitor: synthesis and biological activity of masked amidines as prodrugs of novel 1,4-diazepane derivatives.
Koshio H, Hirayama F, Ishihara T, Kaizawa H, Shigenaga T, Taniuchi Y, Sato K, Moritani Y, Iwatsuki Y, Uemura T, Kaku S, Kawasaki T, Matsumoto Y, Sakamoto S, Tsukamoto S. Koshio H, et al. Among authors: matsumoto y. Bioorg Med Chem. 2004 Oct 15;12(20):5415-26. doi: 10.1016/j.bmc.2004.07.046. Bioorg Med Chem. 2004. PMID: 15388168
Prodrug-based design, synthesis, and biological evaluation of N-benzenesulfonylpiperidine derivatives as novel, orally active factor Xa inhibitors.
Ishihara T, Seki N, Hirayama F, Orita M, Koshio H, Taniuchi Y, Sakai-Moritani Y, Iwatsuki Y, Kaku S, Kawasaki T, Matsumoto Y, Tsukamoto S. Ishihara T, et al. Among authors: matsumoto y. Bioorg Med Chem. 2007 Jun 15;15(12):4175-92. doi: 10.1016/j.bmc.2007.03.066. Epub 2007 Mar 25. Bioorg Med Chem. 2007. PMID: 17416533
An easy access to 7-methyl-2-naphthalenecarbonitrile.
Koshio H, Ishihara T, Yamada H, Hirayama F, Matsumoto Y, Yanagisawa I. Koshio H, et al. Among authors: matsumoto y. Chem Pharm Bull (Tokyo). 2005 Apr;53(4):448-50. doi: 10.1248/cpb.53.448. Chem Pharm Bull (Tokyo). 2005. PMID: 15802851 Free article.
6,122 results