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SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis.
Luthi-Carter R, Taylor DM, Pallos J, Lambert E, Amore A, Parker A, Moffitt H, Smith DL, Runne H, Gokce O, Kuhn A, Xiang Z, Maxwell MM, Reeves SA, Bates GP, Neri C, Thompson LM, Marsh JL, Kazantsev AG. Luthi-Carter R, et al. Among authors: gokce o. Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7927-32. doi: 10.1073/pnas.1002924107. Epub 2010 Apr 8. Proc Natl Acad Sci U S A. 2010. PMID: 20378838 Free PMC article.
Dysregulation of gene expression in primary neuron models of Huntington's disease shows that polyglutamine-related effects on the striatal transcriptome may not be dependent on brain circuitry.
Runne H, Régulier E, Kuhn A, Zala D, Gokce O, Perrin V, Sick B, Aebischer P, Déglon N, Luthi-Carter R. Runne H, et al. Among authors: gokce o. J Neurosci. 2008 Sep 24;28(39):9723-31. doi: 10.1523/JNEUROSCI.3044-08.2008. J Neurosci. 2008. PMID: 18815258 Free PMC article.
Diminished activity-dependent brain-derived neurotrophic factor expression underlies cortical neuron microcircuit hypoconnectivity resulting from exposure to mutant huntingtin fragments.
Gambazzi L, Gokce O, Seredenina T, Katsyuba E, Runne H, Markram H, Giugliano M, Luthi-Carter R. Gambazzi L, et al. Among authors: gokce o. J Pharmacol Exp Ther. 2010 Oct;335(1):13-22. doi: 10.1124/jpet.110.167551. Epub 2010 Jul 12. J Pharmacol Exp Ther. 2010. PMID: 20624994
A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease.
Smith MR, Syed A, Lukacsovich T, Purcell J, Barbaro BA, Worthge SA, Wei SR, Pollio G, Magnoni L, Scali C, Massai L, Franceschini D, Camarri M, Gianfriddo M, Diodato E, Thomas R, Gokce O, Tabrizi SJ, Caricasole A, Landwehrmeyer B, Menalled L, Murphy C, Ramboz S, Luthi-Carter R, Westerberg G, Marsh JL. Smith MR, et al. Among authors: gokce o. Hum Mol Genet. 2014 Jun 1;23(11):2995-3007. doi: 10.1093/hmg/ddu010. Epub 2014 Jan 16. Hum Mol Genet. 2014. PMID: 24436303 Free PMC article.
Decreased Lin7b expression in layer 5 pyramidal neurons may contribute to impaired corticostriatal connectivity in huntington disease.
Zucker B, Kama JA, Kuhn A, Thu D, Orlando LR, Dunah AW, Gokce O, Taylor DM, Lambeck J, Friedrich B, Lindenberg KS, Faull RL, Weiller C, Young AB, Luthi-Carter R. Zucker B, et al. Among authors: gokce o. J Neuropathol Exp Neurol. 2010 Sep;69(9):880-95. doi: 10.1097/NEN.0b013e3181ed7a41. J Neuropathol Exp Neurol. 2010. PMID: 20720508 Free PMC article.
Fused 3-Hydroxy-3-trifluoromethylpyrazoles Inhibit Mutant Huntingtin Toxicity.
La Rosa S, Benicchi T, Bettinetti L, Ceccarelli I, Diodato E, Federico C, Fiengo P, Franceschini D, Gokce O, Heitz F, Lazzeroni G, Luthi-Carter R, Magnoni L, Miragliotta V, Scali C, Valacchi M. La Rosa S, et al. Among authors: gokce o. ACS Med Chem Lett. 2013 Aug 8;4(10):979-84. doi: 10.1021/ml400251g. eCollection 2013 Oct 10. ACS Med Chem Lett. 2013. PMID: 24900595 Free PMC article.
109 results